Detailed view for PF3D7_1233900

Basic information

TDR Targets ID: 5380
Plasmodium falciparum, sentrin-specific protease 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.8322 | Length (AA): 1026 | MW (Da): 123225 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02902   Ulp1 protease family, C-terminal catalytic domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
785 1016 2bzp (A) 419 635 35.00 0 1 0.58 -1.16
786 1016 1th0 (A) 365 580 34.00 0 1 0.74 -1.42
33 260 4tql (A) 9 235 17.00 0.00054 0.09 0.442922 -0.88
806 1019 2g4d (A) 440 638 40.00 0 1 0.725877 -1.07
807 1024 1euv (A) 424 620 32.00 0 1 0.462876 -0.25
819 1025 3zo5 (A) 404 595 37.00 0 1 0.688154 -1.31
823 993 3eay (A) 701 935 27.00 0.00087 0.99 0.323967 -0.18
147 365 4tql (A) 22 235 15.00 0.037 0.01 0.343486 -0.49
802 1015 2g4d (A) 440 638 40.00 0 1 0.726693 -1.07
803 1020 1euv (A) 424 620 33.00 0.0000000000055 1 0.481407 -0.38
818 1021 3zo5 (A) 407 595 37.00 0 1 0.675709 -1.26
819 989 3eay (A) 701 935 27.00 0.00086 0.99 0.324619 -0.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 16 hs, Sporozoite. Otto TD Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Male Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, early trophozoite, Female Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile late trophozoite. PlasmoDB
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_127954)

Species Accession Gene Product
Arabidopsis thaliana AT3G06910   ESD4-like sumo protease 1
Arabidopsis thaliana AT4G00690   UB-like protease 1B
Arabidopsis thaliana AT4G15880   ubiquitin-like-specific protease ESD4
Babesia bovis BBOV_II004090   ulp1 protease family, C-terminal catalytic domain containing protein
Brugia malayi Bm1_17440   Ulp1 protease family, C-terminal catalytic domain containing protein
Candida albicans CaO19.11831   one of three potential ubiquitin-like protein-specific protease genes
Candida albicans CaO19.4353   one of three potential ubiquitin-like protein-specific protease genes
Caenorhabditis elegans CELE_T10F2.3   Protein ULP-1
Cryptosporidium hominis Chro.50094   hypothetical protein
Cryptosporidium parvum cgd5_2810   ULP1 like chllamydin domain containing protease
Dictyostelium discoideum DDB_G0292290   hypothetical protein
Drosophila melanogaster Dmel_CG32110   CG32110 gene product from transcript CG32110-RA
Drosophila melanogaster Dmel_CG11023   CG11023 gene product from transcript CG11023-RB
Drosophila melanogaster Dmel_CG12359   CG12359 gene product from transcript CG12359-RA
Echinococcus granulosus EgrG_000338300   sentrin specific protease 1
Entamoeba histolytica EHI_067510   Ulp1 protease family, C-terminal catalytic domain containing protein
Echinococcus multilocularis EmuJ_000338300   sentrin specific protease 1
Homo sapiens ENSG00000079387   SUMO1/sentrin specific peptidase 1
Loa Loa (eye worm) LOAG_04854   hypothetical protein
Mus musculus ENSMUSG00000033075   SUMO1/sentrin specific peptidase 1
Neospora caninum NCLIV_051630   hypothetical protein
Oryza sativa 4333089   Os03g0410100
Oryza sativa 4326283   Os01g0355900
Plasmodium berghei PBANKA_1448500   sentrin-specific protease 1, putative
Plasmodium falciparum PF3D7_1233900   sentrin-specific protease 1
Plasmodium knowlesi PKNH_1453300   sentrin-specific protease 1, putative
Plasmodium vivax PVX_100650   sentrin-specific protease 1, putative
Plasmodium yoelii PY02388   similar to sentrin/SUMO-specific protease
Saccharomyces cerevisiae YPL020C   Ulp1p
Schistosoma japonicum Sjp_0033730   ko:K08592 sentrin-specific protease 1, putative
Schistosoma mansoni Smp_033260.1   family C48 unassigned peptidase (C48 family)
Schistosoma mansoni Smp_033260.2   family C48 unassigned peptidase (C48 family)
Schmidtea mediterranea mk4.002766.02   Sentrin-specific protease
Toxoplasma gondii TGME49_214470   Ulp1 protease family, C-terminal catalytic domain-containing protein
Theileria parva TP04_0173   hypothetical protein
Trichomonas vaginalis TVAG_094560   Clan CE, family C48, Ulp1-like cysteine peptidase

Essentiality

PF3D7_1233900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T10F2.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T10F2.3 Caenorhabditis elegans slow growth wormbase
YPL020C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1448500 Plasmodium berghei Essential plasmo
TGME49_214470 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens SUMO1/sentrin specific peptidase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0052 0.9042 1
0.0052 0.9043 1
0.0053 0.5317 0.5
0.0056 0.9043 1
0.0193 0.3725 1
0.0102 0.956 1
0.0056 0.9043 1
0.0046 0.5783 1
0.0056 1 0.5
0.0056 0.4259 1
0.0056 0.5 0.5
0.0103 0.5332 0.5
0.0111 0.9117 1
0.0056 0.5 0.5
0.0248 0.4053 1
0.0072 0.5 0.5
0.0056 0.6075 0.6075
0.005 0.2687 1
0.0052 0.9043 1
0.01 0.5 0.5
0.0056 0.5 0.5
0.0055 0.3457 0.5
0.0045 0.6325 0.5
0.0056 0.338 1
0.0056 0.262 0.5
0.0245 0.8223 0.5
0.01 0.9125 1
0.0194 0.2691 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier PF3D7_1233900 (Plasmodium falciparum), sentrin-specific protease 1
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