Detailed view for TcCLB.509669.20

Basic information

TDR Targets ID: 53895
Trypanosoma cruzi, subtilisin-like serine peptidase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.8929 | Length (AA): 1371 | MW (Da): 149775 | Paralog Number: 1

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00082   Subtilase family
PF00431   CUB domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
363 666 1thm (A) 24 272 25.00 0 1 0.249036 0.07
363 795 1wmd (A) 15 433 27.00 0 1 0.444128 0.16
813 906 2ygq (A) 182 264 41.00 0.00072 0.97 0.239563 0.88
882 947 1uha (A) 10 65 38.00 0.74 1 0.34114 -0.71
947 1086 1szb (A) 7 155 31.00 0.27 0.46 0.256115 0.44
952 1056 1sfp (A) 7 111 16.00 0 0.44 0.197886 -0.62
953 1058 1spp (B) 7 112 17.00 0 0.57 0.206616 -0.46

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_134947)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0293002   ABC transporter B family protein
Dictyostelium discoideum DDB_G0286119   ABC transporter B family protein
Dictyostelium discoideum DDB_G0286123   ABC transporter B family protein
Dictyostelium discoideum DDB_G0286121   ABC transporter B family protein
Trypanosoma cruzi TcCLB.509669.20   subtilisin-like serine peptidase, putative
Trypanosoma cruzi TcCLB.509617.70   subtilisin-like serine peptidase, putative
Trichomonas vaginalis TVAG_090240   Clan SB, family S8, subtilisin-like serine peptidase

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.3

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bacillus lentus Subtilisin 269 aa 28.1% 302 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0124 0.3617 1
0.0139 0.3164 0.5
0.0152 0.3381 0.5
0.0034 0.3155 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcCLB.509669.20 (Trypanosoma cruzi), subtilisin-like serine peptidase, putative
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