Detailed view for TcCLB.503809.90

Basic information

TDR Targets ID: 53908
Trypanosoma cruzi, glycerol uptake protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.4412 | Length (AA): 619 | MW (Da): 71524 | Paralog Number: 4

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03062   MBOAT, membrane-bound O-acyltransferase family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
299 357 5fmv (A) 421 486 36.00 0.3 0.46 0.184815 1.59

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128109)

Species Accession Gene Product
Arabidopsis thaliana AT1G57600   MBOAT (membrane bound O-acyl transferase)-like protein
Brugia malayi Bm1_38580   Hhat protein
Brugia malayi Bm1_17700   hypothetical protein
Candida albicans CaO19.4985   putative glycerol transporter
Candida albicans CaO19.12452   putative glycerol transporter
Caenorhabditis elegans CELE_ZC101.3   Protein HHAT-1
Dictyostelium discoideum DDB_G0288599   membrane bound O-acyl transferase family protein
Drosophila melanogaster Dmel_CG11495   CG11495 gene product from transcript CG11495-RA
Echinococcus granulosus EgrG_000471750   membrane bound acyltransferase:hhat
Echinococcus multilocularis EmuJ_000471750   membrane bound acyltransferase:hhat
Homo sapiens ENSG00000054392   hedgehog acyltransferase
Leishmania braziliensis LbrM.19.1560   glycerol uptake protein, putative
Leishmania braziliensis LbrM.19.1600   glycerol uptake protein, putative
Leishmania braziliensis LbrM.19.1510   glycerol uptake protein, putative
Leishmania braziliensis LbrM.19.1520   glycerol uptake protein, putative
Leishmania braziliensis LbrM.19.1530   glycerol uptake protein, putative
Leishmania braziliensis LbrM.19.1550   glycerol uptake protein, putative
Leishmania braziliensis LbrM.19.1590   glycerol uptake protein, putative
Leishmania braziliensis LbrM.19.1580   glycerol uptake protein, putative
Leishmania donovani LdBPK_191370.1   membrane-bound O-acyltransferase, putative
Leishmania infantum LinJ.19.1310   glycerol uptake protein, putative
Leishmania infantum LinJ.19.1350   glycerol uptake protein, putative
Leishmania infantum LinJ.19.1370   hypothetical protein, conserved
Leishmania infantum LinJ.35.2120   glycerol uptake protein, putative
Leishmania infantum LinJ.19.1330   glycerol uptake protein, putative
Leishmania infantum LinJ.35.2130   glycerol uptake protein, putative
Leishmania infantum LinJ.19.1320   glycerol uptake protein, putative
Leishmania infantum LinJ.19.1340   glycerol uptake protein, putative
Leishmania infantum LinJ.19.1360   glycerol uptake protein, putative
Leishmania infantum LinJ.35.2140   glycerol uptake protein, putative
Leishmania major LmjF.19.1320   glycerol uptake protein, putative
Leishmania major LmjF.19.1000   glycerol uptake protein, putative
Leishmania major LmjF.19.1330   glycerol uptake protein, putative
Leishmania major LmjF.19.1345   glycerol uptake protein, putative
Leishmania major LmjF.19.1340   glycerol uptake protein, putative
Leishmania major LmjF.19.1347   hypothetical protein, conserved
Leishmania mexicana LmxM.19.1320   glycerol uptake protein, putative
Leishmania mexicana LmxM.19.1345apartial  
Leishmania mexicana LmxM.19.1345   glycerol uptake protein, putative
Loa Loa (eye worm) LOAG_14072   hypothetical protein
Loa Loa (eye worm) LOAG_14202   hhat protein
Loa Loa (eye worm) LOAG_16080   hypothetical protein
Loa Loa (eye worm) LOAG_15524   hhat protein
Mus musculus ENSMUSG00000037375   hedgehog acyltransferase
Oryza sativa 4337781   Os05g0144000
Saccharomyces cerevisiae YGL084C   Gup1p
Saccharomyces cerevisiae YPL189W   Gup2p
Trypanosoma brucei gambiense Tbg972.10.19500   glycerol uptake protein, putative
Trypanosoma brucei Tb11.v5.0406   glycerol uptake protein, putative
Trypanosoma brucei Tb11.v5.0301   glycerol uptake protein, putative
Trypanosoma congolense TcIL3000_10_13730   glycerol uptake protein, putative
Trypanosoma cruzi TcCLB.503809.100   GUP1, putative
Trypanosoma cruzi TcCLB.508943.4   glycerol uptake protein, putative
Trypanosoma cruzi TcCLB.503809.90   glycerol uptake protein, putative
Trypanosoma cruzi TcCLB.511355.50   glycerol uptake protein, putative
Trypanosoma cruzi TcCLB.511355.40   GUP1, putative

Essentiality

TcCLB.503809.90 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.15910 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.15910 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.15910 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.15910 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YGL084C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0043 0.293 1
0.0024 0.3982 0.3734
0.0042 0.3061 1
0.0046 0.5 0.5
0.0022 0.3737 0.3235
0.0024 0.3925 0.3662

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.503809.90 (Trypanosoma cruzi), glycerol uptake protein, putative
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