Detailed view for Tbg972.10.1330

Basic information

TDR Targets ID: 539489
Trypanosoma brucei gambiense, cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative
Source Database / ID: 

pI: 6.7435 | Length (AA): 301 | MW (Da): 34351 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 298 3niz (A) 19 305 55.00 0 1 1.62763 -0.77
2 298 4au8 (A) 1 287 57.00 0 1 1.63931 -0.92
2 301 4krd (A) 4 301 51.00 0 1 1.65228 -0.85
4 300 1v0o (B) 3 287 58.00 0 1 1.65431 -0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126712)

Species Accession Gene Product
Arabidopsis thaliana AT3G48750   cyclin-dependent kinase A-1
Babesia bovis BBOV_IV010650   cell division control protein 2, putative
Brugia malayi Bm1_01435   cell division control protein 2 homolog
Brugia malayi Bm1_18520   Protein kinase domain containing protein
Candida albicans CaO19.11337   Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase
Candida albicans CaO19.3856   Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase
Caenorhabditis elegans CELE_T05G5.3   Protein CDK-1
Caenorhabditis elegans CELE_T27E9.3   Protein CDK-5
Cryptosporidium hominis Chro.50127   cdc2-like protein kinase
Cryptosporidium parvum cgd5_2510   Cdc2-like CDK2/CDC28 like protein kinase
Dictyostelium discoideum DDB_G0272813   CDC2 subfamily protein kinase
Dictyostelium discoideum DDB_G0288677   CDK family protein kinase
Drosophila melanogaster Dmel_CG5363   CG5363 gene product from transcript CG5363-RA
Drosophila melanogaster Dmel_CG8203   Cyclin-dependent kinase 5
Drosophila melanogaster Dmel_CG10498   CG10498 gene product from transcript CG10498-RC
Echinococcus granulosus EgrG_001201200   cyclin dependent kinase 1
Echinococcus granulosus EgrG_002003450   5'partial|cyclin dependent kinase 1
Echinococcus granulosus EgrG_000258800   cyclin dependent kinase 5
Echinococcus granulosus EgrG_000659500   cyclin dependent kinase
Entamoeba histolytica EHI_152430   cell division protein kinase 2, putative
Entamoeba histolytica EHI_065280   cell division protein kinase 2, putative
Echinococcus multilocularis EmuJ_000258800   cyclin dependent kinase 5
Echinococcus multilocularis EmuJ_001201200   cyclin dependent kinase 1
Echinococcus multilocularis EmuJ_000046100   cyclin dependent kinase 1
Echinococcus multilocularis EmuJ_000659500   cyclin dependent kinase
Giardia lamblia GL50803_8037   Kinase, CMGC CDK
Giardia lamblia GL50803_16802   Kinase, CMGC CDK
Homo sapiens ENSG00000164885   cyclin-dependent kinase 5
Homo sapiens ENSG00000170312   cyclin-dependent kinase 1
Homo sapiens ENSG00000261408   cyclin-dependent kinase 3
Leishmania braziliensis LbrM.35.0660   cell division related protein kinase 2,cdc2-related kinase
Leishmania braziliensis LbrM.21.1310   cell division protein kinase 2,cdc2-related kinase
Leishmania donovani LdBPK_211320.1   cell division protein kinase 2
Leishmania donovani LdBPK_360600.1   cdc2-related kinase 3, putative
Leishmania infantum LinJ.36.0600   cell division related protein kinase 2,cdc2-related kinase
Leishmania infantum LinJ.21.1320   cell division protein kinase 2,cdc2-related kinase
Leishmania major LmjF.36.0550   cell division related protein kinase 2,cdc2-related kinase
Leishmania major LmjF.21.1080   cell division protein kinase 2,cdc2-related kinase
Leishmania mexicana LmxM.21.1080   cell division protein kinase 2,cdc2-related kinase
Leishmania mexicana LmxM.36.0550   cell division related protein kinase 2,cdc2-related kinase
Loa Loa (eye worm) LOAG_07241   hypothetical protein
Loa Loa (eye worm) LOAG_07240   CMGC/CDK/CDK5 protein kinase
Loa Loa (eye worm) LOAG_04543   CMGC/CDK/CDC2 protein kinase
Loa Loa (eye worm) LOAG_00683   CMGC/CDK/CDC2 protein kinase
Mus musculus ENSMUSG00000019942   cyclin-dependent kinase 1
Mus musculus ENSMUSG00000025358   cyclin-dependent kinase 2
Mus musculus ENSMUSG00000028969   cyclin-dependent kinase 5
Neospora caninum NCLIV_062010   CMGC kinase, CDK family TgPK2, putative
Oryza sativa 4331415   Os03g0118400
Oryza sativa 4331341   Os03g0108800
Oryza sativa 9269568   Os01g0897000
Oryza sativa 4328135   Os02g0123100
Plasmodium berghei PBANKA_1133200   cdc2-related kinase 2
Plasmodium falciparum PF3D7_1356900   protein kinase 5
Plasmodium knowlesi PKNH_1114600   Cell division control protein 2 homolog
Plasmodium vivax PVX_114825   protein kinase Crk2
Plasmodium yoelii PY02339   cdc2-related kinase 2
Saccharomyces cerevisiae YBR160W   cyclin-dependent serine/threonine-protein kinase CDC28
Saccharomyces cerevisiae YPL031C   cyclin-dependent serine/threonine-protein kinase PHO85
Schistosoma japonicum Sjp_0069610   ko:K02090 cyclin-dependent kinase 5, putative
Schistosoma japonicum Sjp_0031130   ko:K02087 cyclin-dependent kinase 1, putative
Schistosoma mansoni Smp_073340   serine/threonine protein kinase
Schistosoma mansoni Smp_080730   serine/threonine protein kinase
Schmidtea mediterranea mk4.004426.03  
Schmidtea mediterranea mk4.004810.01  
Schmidtea mediterranea mk4.003639.00  
Schmidtea mediterranea mk4.016510.00   Cyclin-dependent kinase 5
Schmidtea mediterranea mk4.004403.00   Cell division control protein 2 cognate
Schmidtea mediterranea mk4.001381.05   Cyclin-dependent kinase 1
Schmidtea mediterranea mk4.001869.00  
Schmidtea mediterranea mk4.008987.01   Cyclin-dependent kinase 1
Schmidtea mediterranea mk4.008987.00   Cyclin-dependent kinase 1
Schmidtea mediterranea mk4.005251.00  
Schmidtea mediterranea mk4.003110.00   Cell division control protein 2 cognate
Schmidtea mediterranea mk4.008040.02   Cyclin-dependent kinase 1
Schmidtea mediterranea mk4.016640.01  
Schmidtea mediterranea mk4.002949.00   Cyclin-dependent kinase 1
Schmidtea mediterranea mk4.003414.10   Cyclin-dependent kinase 1
Trypanosoma brucei gambiense Tbg972.10.1330   cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative
Trypanosoma brucei gambiense Tbg972.10.6040   cell division related protein kinase 2, putative,CDC2-related protein kinase
Trypanosoma brucei Tb927.10.4990   cdc2-related kinase 3
Trypanosoma brucei Tb927.10.1070   cdc2-related kinase 1
Trypanosoma congolense TcIL3000_10_4170   cdc2-related kinase 3, putative
Trypanosoma congolense TcIL3000_10_880   cdc2-related kinase 1, putative
Trypanosoma cruzi TcCLB.509695.190   cdc2-related kinase 1
Trypanosoma cruzi TcCLB.506677.20   cdc2-related kinase 3
Trypanosoma cruzi TcCLB.506583.40   cdc2-related kinase 3
Trypanosoma cruzi TcCLB.504181.40   cdc2-related kinase 1
Toxoplasma gondii TGME49_218220   cell-cycle-associated protein kinase CDK, putative
Theileria parva TP01_0728   cell division control protein 2 related kinase
Trichomonas vaginalis TVAG_453900   CMGC family protein kinase
Trichomonas vaginalis TVAG_076000   CMGC family protein kinase
Trichomonas vaginalis TVAG_225330   CMGC family protein kinase

Essentiality

Tbg972.10.1330 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.4990 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.4990 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.4990 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.4990 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.1070 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.1070 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.1070 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.1070 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T05G5.3 Caenorhabditis elegans embryonic arrest wormbase
CELE_T05G5.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T05G5.3 Caenorhabditis elegans slow growth wormbase
CELE_T05G5.3 Caenorhabditis elegans sterile wormbase
CELE_T27E9.3 Caenorhabditis elegans embryonic lethal wormbase
YBR160W Saccharomyces cerevisiae inviable yeastgenome
TGME49_218220 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Saccharomyces cerevisiae cyclin-dependent serine/threonine-protein kinase PHO85 Compounds References
Patiria pectinifera Cdc2 Compounds References
Mus musculus cyclin-dependent kinase 1 Compounds References
Homo sapiens cyclin-dependent kinase 5 Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog Compounds References
Saccharomyces cerevisiae cyclin-dependent serine/threonine-protein kinase CDC28 Compounds References
Homo sapiens cyclin-dependent kinase 3 Compounds References
Rattus norvegicus Cell division protein kinase 5 Compounds References
Plasmodium falciparum protein kinase 5 Compounds References
Leishmania major cell division related protein kinase 2,cdc2-related kinase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 44.4% 189 aa Compounds References
Homo sapiens Cyclin-dependent kinase 1/cyclin B1 297 aa 53.0% 296 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Tbg972.10.1330 (Trypanosoma brucei gambiense), cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative
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