Detailed view for Tbg972.8.7320

Basic information

TDR Targets ID: 542129
Trypanosoma brucei gambiense, acetyl-CoA carboxylase, putative
Source Database / ID: 

pI: 6.5905 | Length (AA): 2181 | MW (Da): 242943 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00289   Biotin carboxylase, N-terminal domain
PF00364   Biotin-requiring enzyme
PF01039   Carboxyl transferase domain
PF02785   Biotin carboxylase C-terminal domain
PF02786   Carbamoyl-phosphate synthase L chain, ATP binding domain
PF08326   Acetyl-CoA carboxylase, central region

Gene Ontology

Mouse over links to read term descriptions.
GO:0046872   metal ion binding  
GO:0016874   ligase activity  
GO:0005524   ATP binding  
GO:0003989   acetyl-CoA carboxylase activity  
GO:0006633   fatty acid biosynthetic process  

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 2127 5csk (B) 37 2193 35.00 0 1 1.03443 0.27
11 523 2hjw (A) 241 759 51.00 0 1 0.766713 -0.66
17 2117 5csk (A) 46 2183 33.00 0 1 1.13882 0.55
1051 2157 5i6f (A) 1187 2320 37.00 0 1 0.551965 0.35
1416 2174 3ff6 (A) 1695 2446 40.00 0 1 0.516406 0.01
1421 2172 4asi (A) 1618 2370 39.00 0 1 0.528196 -0.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127493)

Species Accession Gene Product
Arabidopsis thaliana AT1G36180   acetyl-CoA carboxylase 2
Arabidopsis thaliana AT1G36160   acetyl-CoA carboxylase 1
Brugia malayi Bm1_40045   Carboxyl transferase domain containing protein
Candida albicans CaO19.7466   acetyl-CoA carboxylase
Caenorhabditis elegans CELE_W09B6.1   Protein POD-2, isoform A
Caenorhabditis elegans CELE_T28F3.5   Protein T28F3.5, isoform B
Cryptosporidium hominis Chro.80425   acetyl-CoA carboxylase 2
Cryptosporidium parvum cgd8_3680   acetyl-CoA carboxylase like biotin dependent carboxylase involved in fatty acid biosynthesis
Dictyostelium discoideum DDB_G0288387   acetyl-CoA carboxylase
Drosophila melanogaster Dmel_CG11198   Acetyl-CoA carboxylase
Echinococcus granulosus EgrG_000592700   acetyl coenzyme A carboxylase 1
Echinococcus multilocularis EmuJ_000592700   acetyl coenzyme A carboxylase 1
Homo sapiens ENSG00000278540   acetyl-CoA carboxylase alpha
Homo sapiens ENSG00000076555   acetyl-CoA carboxylase beta
Leishmania braziliensis LbrM.31.3340   acetyl-CoA carboxylase, putative
Leishmania donovani LdBPK_313080.1   acetyl-CoA carboxylase
Leishmania infantum LinJ.31.3080   acetyl-CoA carboxylase, putative
Leishmania major LmjF.31.2970   acetyl-CoA carboxylase, putative
Leishmania mexicana LmxM.30.2970   acetyl-CoA carboxylase, putative
Loa Loa (eye worm) LOAG_03909   carboxyl transferase domain-containing protein
Mus musculus 102641888   acetyl-CoA carboxylase 1-like
Mus musculus ENSMUSG00000042010   acetyl-Coenzyme A carboxylase beta
Mus musculus ENSMUSG00000020532   acetyl-Coenzyme A carboxylase alpha
Neospora caninum NCLIV_061720   hypothetical protein
Neospora caninum NCLIV_004860   hypothetical protein
Plasmodium berghei PBANKA_1332800   biotin carboxylase subunit of acetyl CoA carboxylase, putative
Plasmodium falciparum PF3D7_1469600   biotin carboxylase subunit of acetyl CoA carboxylase, putative
Plasmodium knowlesi PKNH_1211400   biotin carboxylase subunit of acetyl CoA carboxylase, putative
Plasmodium vivax PVX_116985   biotin carboxylase subunit of acetyl CoA carboxylase, putative
Plasmodium yoelii PY01695   acetyl-CoA carboxylase 1 precursor-related
Saccharomyces cerevisiae YMR207C   acetyl-CoA carboxylase HFA1
Saccharomyces cerevisiae YNR016C   acetyl-CoA carboxylase ACC1
Schistosoma japonicum Sjp_0089770   Acetyl-CoA carboxylase, putative
Schistosoma japonicum Sjp_0081470   ko:K01946 biotin carboxylase [EC6.3.4.14], putative
Schistosoma japonicum Sjp_0117400   hypothetical protein
Schistosoma japonicum Sjp_0107560   Acetyl-CoA carboxylase, putative
Schistosoma japonicum Sjp_0086560   ko:K01961 acetyl-CoA carboxylase [EC6.4.1.2], putative
Schistosoma mansoni Smp_123710   acetyl-CoA carboxylase
Schmidtea mediterranea mk4.014105.00  
Schmidtea mediterranea mk4.039102.01  
Schmidtea mediterranea mk4.008213.05  
Schmidtea mediterranea mk4.026359.00  
Schmidtea mediterranea mk4.008213.03   Acetyl-CoA carboxylase
Schmidtea mediterranea mk4.012651.03  
Schmidtea mediterranea mk4.008213.07  
Schmidtea mediterranea mk4.025520.00  
Schmidtea mediterranea mk4.016388.01  
Schmidtea mediterranea mk4.007413.02  
Schmidtea mediterranea mk4.007413.00  
Schmidtea mediterranea mk4.022847.00  
Schmidtea mediterranea mk4.033594.00  
Schmidtea mediterranea mk4.039102.00   Acetyl-CoA carboxylase
Schmidtea mediterranea mk4.008213.04  
Schmidtea mediterranea mk4.012651.04   Acetyl-CoA carboxylase
Schmidtea mediterranea mk4.008213.06  
Trypanosoma brucei gambiense Tbg972.8.7320   acetyl-CoA carboxylase, putative
Trypanosoma brucei Tb927.8.7100   acetyl-CoA carboxylase
Trypanosoma congolense TcIL3000_8_7160   acetyl-CoA carboxylase
Trypanosoma congolense TcIL3000_0_19850   acetyl-CoA carboxylase
Trypanosoma cruzi TcCLB.474937.9   acetyl-CoA carboxylase
Toxoplasma gondii TGME49_221320   acetyl-CoA carboxylase ACC1
Toxoplasma gondii TGME49_218560   acetyl-coA carboxylase ACC2

Essentiality

Tbg972.8.7320 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.7100 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.7100 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.8.7100 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.7100 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_W09B6.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_W09B6.1 Caenorhabditis elegans larval arrest wormbase
CELE_W09B6.1 Caenorhabditis elegans larval lethal wormbase
CELE_W09B6.1 Caenorhabditis elegans slow growth wormbase
YNR016C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1332800 Plasmodium berghei Essential plasmo
TGME49_221320 Toxoplasma gondii Probably essential sidik
TGME49_218560 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus acetyl-Coenzyme A carboxylase beta Compounds References
Zea mays Acetyl-CoA carboxylase Compounds References
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative Compounds References
Homo sapiens acetyl-CoA carboxylase beta Compounds References
Rattus norvegicus Acetyl-CoA carboxylase 1 Compounds References
Homo sapiens acetyl-CoA carboxylase alpha Compounds References
Mus musculus acetyl-Coenzyme A carboxylase alpha Compounds References
Rattus norvegicus Acetyl-Coenzyme A carboxylase 2 Compounds References
Alopecurus japonicus ACCase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Tbg972.8.7320 (Trypanosoma brucei gambiense), acetyl-CoA carboxylase, putative
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