Detailed view for Tbg972.11.14320

Basic information

TDR Targets ID: 544610
Trypanosoma brucei gambiense, oligopeptidase B, putative
Source Database / ID: 

pI: 6.289 | Length (AA): 715 | MW (Da): 80681 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00326   Prolyl oligopeptidase family
PF02897   Prolyl oligopeptidase, N-terminal beta-propeller domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0070008   GO:serine-type exopeptidase activity  

GO:0008236   serine-type peptidase activity  
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

Chagas disease (KEGG)
African trypanosomiasis (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 715 4bp8 (A) 3 715 99.99 0 1 2.1783 -0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129201)

Species Accession Gene Product
Arabidopsis thaliana AT1G50380   prolyl oligopeptidase family protein
Arabidopsis thaliana AT1G69020   prolyl oligopeptidase-like protein
Babesia bovis BBOV_II002340   hypothetical protein
Dictyostelium discoideum DDB_G0292866   oligopeptidase B
Escherichia coli b1845   protease II
Homo sapiens ENSG00000138078   prolyl endopeptidase-like
Leishmania braziliensis LbrM.09.0850   oligopeptidase b;with=GeneDB:LmjF09.0770
Leishmania donovani LdBPK_090820.1   oligopeptidase b
Leishmania infantum LinJ.09.0820   oligopeptidase b;with=GeneDB:LmjF09.0770
Leishmania major LmjF.09.0770   oligopeptidase b
Leishmania mexicana LmxM.09.0770   oligopeptidase b,serine peptidase, clan SC, family S9A-like protein
Mycobacterium leprae ML2226c   PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)
Mus musculus ENSMUSG00000024127   prolyl endopeptidase-like
Mycobacterium tuberculosis Rv0782   Probable protease II PtrBb [second part] (oligopeptidase B)
Mycobacterium ulcerans MUL_0498   protease II (oligopeptidase B), PtrB
Oryza sativa 4342148   Os06g0730600
Oryza sativa 4347361   Os09g0475700
Schmidtea mediterranea mk4.054779.00  
Schmidtea mediterranea mk4.040425.01   Prolyl endopeptidase-like
Schmidtea mediterranea mk4.040425.02  
Trypanosoma brucei gambiense Tbg972.11.14320   oligopeptidase B, putative
Trypanosoma brucei Tb927.11.12850   oligopeptidase b
Trypanosoma congolense TcIL3000_0_35790   oligopeptidase b
Trypanosoma cruzi TcCLB.511557.10   oligopeptidase b
Trypanosoma cruzi TcCLB.503995.50   oligopeptidase b
Theileria parva TP04_0365   protease II, putative

Essentiality

Tbg972.11.14320 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.52.0003 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.52.0003 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.52.0003 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.52.0003 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
b1845 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Prolyl endopeptidase 710 aa 26.7% 621 aa Compounds References
Trypanosoma cruzi prolyl endopeptidase 697 aa 23.9% 703 aa Compounds References
Elizabethkingia meningoseptica Prolyl endopeptidase 705 aa 27.2% 716 aa Compounds References
Sus scrofa Prolyl endopeptidase 710 aa 26.4% 629 aa Compounds References
Rattus norvegicus Prolyl endopeptidase 710 aa 27.2% 626 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tbg972.11.14320 (Trypanosoma brucei gambiense), oligopeptidase B, putative
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