Detailed view for Tbg972.6.220

Basic information

TDR Targets ID: 545130
Trypanosoma brucei gambiense, cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative
Source Database / ID: 

pI: 5.8391 | Length (AA): 340 | MW (Da): 37284 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00112   Papain family cysteine protease

Gene Ontology

Mouse over links to read term descriptions.
GO:0008234   cysteine-type peptidase activity  
GO:0006508   proteolysis  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
27 340 4hwy (A) 27 340 99.99 0 1 2.12613 -1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127800)

Species Accession Gene Product
Arabidopsis thaliana AT1G02300   putative cathepsin B-like cysteine protease
Arabidopsis thaliana AT1G02305   putative cathepsin B-like cysteine protease
Arabidopsis thaliana AT4G01610   putative cathepsin B-like cysteine protease
Brugia malayi Bm1_33735   cathepsin B-like cysteine proteinase
Caenorhabditis elegans CELE_F57F5.1   Protein F57F5.1
Caenorhabditis elegans CELE_F44C4.3   Protein CPR-4
Caenorhabditis elegans CELE_W07B8.5   Protein CPR-5
Caenorhabditis elegans CELE_C25B8.3   Protein CPR-6, isoform A
Dictyostelium discoideum DDB_G0288563   hypothetical protein
Dictyostelium discoideum DDB_G0283921   cathepsin B precursor
Drosophila melanogaster Dmel_CG10992   Cathepsin B1
Echinococcus granulosus EgrG_000790300   cathepsin b
Echinococcus granulosus EgrG_000790200   cathepsin b
Echinococcus multilocularis EmuJ_000790300   cathepsin b
Echinococcus multilocularis EmuJ_000790200   cathepsin b
Giardia lamblia GL50803_14019   Cathepsin B precursor
Giardia lamblia GL50803_16160   Cathepsin B precursor
Giardia lamblia GL50803_16779   Cathepsin B precursor
Homo sapiens ENSG00000164733   cathepsin B
Leishmania braziliensis LbrM.29.0850   cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like
Leishmania donovani LdBPK_290860.1   cysteine peptidase C (CPC)
Leishmania infantum LinJ.29.0860   cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like
Leishmania major LmjF.29.0820   cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like
Leishmania mexicana LmxM.08_29.0820   cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like
Loa Loa (eye worm) LOAG_08355   hypothetical protein
Loa Loa (eye worm) LOAG_11371   cathepsin B
Mus musculus ENSMUSG00000021939   cathepsin B
Neospora caninum NCLIV_069550   Cathepsin B-like protease (Precursor), related
Oryza sativa 9267789   Os05g0310500
Schistosoma japonicum Sjp_0214180   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0077110   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0089450   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0089420   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0131900   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0007940   ko:K01363 cathepsin B [EC3.4.22.1], putative
Schistosoma japonicum Sjp_0068040   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0303350   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0218410   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0214190   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma mansoni Smp_103610   cathepsin B-like peptidase (C01 family)
Schistosoma mansoni Smp_158420   cathepsin B-like peptidase (C01 family)
Schistosoma mansoni Smp_179950   cathepsin B-like peptidase (C01 family)
Schistosoma mansoni Smp_067060   cathepsin B-like peptidase (C01 family)
Schistosoma mansoni Smp_141610   SmCB2 peptidase (C01 family)
Schmidtea mediterranea mk4.002490.00   Cathepsin B
Schmidtea mediterranea mk4.000308.13   Cathepsin B
Trypanosoma brucei gambiense Tbg972.6.220   cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative
Trypanosoma brucei Tb927.6.560   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_11180   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_28450   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_6_60   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_03600   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_41960   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_15150   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_48140   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_56080   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_32450   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_48090   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_35720   cysteine peptidase C (CPC)
Trypanosoma congolense TcIL3000_0_45430   cysteine peptidase C (CPC)
Trypanosoma cruzi TcCLB.510535.100   cysteine peptidase C (CPC), putative
Trypanosoma cruzi TcCLB.511827.100   cysteine peptidase C (CPC), putative
Toxoplasma gondii TGME49_249670   cathepsin B
Trichomonas vaginalis TVAG_482410   Clan CA, family C1, cathepsin B-like cysteine peptidase

Essentiality

Tbg972.6.220 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.6.560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.6.560 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.6.560 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.6.560 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F57F5.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_F57F5.1 Caenorhabditis elegans larval arrest wormbase
TGME49_249670 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound Source Reference
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Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus Cathepsin B Compounds References
Homo sapiens cathepsin B Compounds References
Bos taurus Cathepsin B Compounds References
Trypanosoma brucei cysteine peptidase C (CPC) Compounds References
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Compounds References
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Compounds References
Capra hircus Cathepsin B Compounds References
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Compounds References
Mus musculus cathepsin B Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Cathepsin K 329 aa 26.7% 270 aa Compounds References
Rattus norvegicus Cathepsin K 329 aa 27.5% 269 aa Compounds References
Bos taurus Cathepsin L 334 aa 28.3% 286 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease ChEMBL
  • Inhibition of Trypanosoma brucei cathepsin B-like cysteine protease
  • ChEMBL
  • Inhibition of Trypanosoma brucei Cathepsin B-like protease after 5 mins
  • ChEMBL
  • Inhibition of Trypanosoma brucei CatB

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tbg972.6.220 (Trypanosoma brucei gambiense), cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative
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