Detailed view for PF3D7_1241600

Basic information

TDR Targets ID: 5454
Plasmodium falciparum, mitochondrial carrier protein, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 9.0234 | Length (AA): 256 | MW (Da): 28774 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005743   mitochondrial inner membrane  
GO:0005488   binding  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 252 1okc (A) 5 291 16.00 0 0.02 0.99 -0.49
6 71 4c9h (A) 130 215 30.00 0.3 0.02 0.313013 0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, early trophozoite, late trophozoite. Otto TD PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 24 hs, late ring, late schizont, Oocyst. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, Ring, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD Zanghi G Lasonder E
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_128405)

Species Accession Gene Product
Arabidopsis thaliana AT4G39460   S-adenosylmethionine carrier 1
Arabidopsis thaliana AT1G34065   S-adenosylmethionine carrier 2
Brugia malayi Bm1_57130   Mitochondrial carrier protein
Candida albicans CaO19_7082   hypothetical protein
Candida albicans CaO19.7082   likely mitochondrial carrier protein similar to S. cerevisiae PET8 (YNL003C) mitochondrial inner membrane S-adenosylmethionine t
Caenorhabditis elegans CELE_D1046.3   Protein D1046.3
Cryptosporidium hominis Chro.60274   mitochondrial carrier protein
Cryptosporidium parvum cgd6_2350   mitochondrial carrier protein, 4 transmembrane domain
Drosophila melanogaster Dmel_CG4743   CG4743 gene product from transcript CG4743-RA
Echinococcus granulosus EgrG_000720700   S adenosylmethionine mitochondrial carrier
Echinococcus granulosus EgrG_000720800   S adenosylmethionine mitochondrial carrier
Echinococcus granulosus EgrG_000720200   S adenosylmethionine mitochondrial carrier
Echinococcus multilocularis EmuJ_000720700   S adenosylmethionine mitochondrial carrier
Echinococcus multilocularis EmuJ_000720200   S adenosylmethionine mitochondrial carrier
Echinococcus multilocularis EmuJ_000720800   S adenosylmethionine mitochondrial carrier
Homo sapiens ENSG00000144741   solute carrier family 25 (S-adenosylmethionine carrier), member 26
Leishmania braziliensis LbrM.32.0170   mitochondrial carrier protein, putative
Leishmania donovani LdBPK_320110.1   mitochondrial carrier protein, putative
Leishmania infantum LinJ.32.0110   mitochondrial carrier protein, putative
Leishmania major LmjF.32.0110   mitochondrial carrier protein, putative
Leishmania mexicana LmxM.31.0110   mitochondrial carrier protein, putative
Loa Loa (eye worm) LOAG_07771   hypothetical protein
Mus musculus ENSMUSG00000045100   solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
Neospora caninum NCLIV_017590   Mitochondrial carrier protein-like, related
Oryza sativa 4338540   Os05g0361900
Oryza sativa 4342959   Os07g0295000
Plasmodium berghei PBANKA_1455000   mitochondrial carrier protein, putative
Plasmodium falciparum PF3D7_1241600   mitochondrial carrier protein, putative
Plasmodium knowlesi PKNH_1460700   mitochondrial carrier protein, putative
Plasmodium vivax PVX_100980   mitochondrial carrier protein, putative
Plasmodium yoelii PY01494   hypothetical protein
Saccharomyces cerevisiae YNL003C   Pet8p
Schistosoma japonicum Sjp_0097220   S-adenosylmethionine mitochondrial carrier protein, putative
Schistosoma japonicum Sjp_0306620   S-adenosylmethionine mitochondrial carrier protein, putative
Schistosoma mansoni Smp_044160   mitochondrial carrier protein
Schmidtea mediterranea mk4.004305.00   S-adenosylmethionine mitochondrial carrier protein
Trypanosoma brucei gambiense Tbg972.10.17360   mitochondrial carrier protein, putative
Trypanosoma brucei Tb927.10.14280   mitochondrial carrier protein
Trypanosoma congolense TcIL3000_10_12160   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.511283.124   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.506525.130   mitochondrial carrier protein, putative
Toxoplasma gondii TGME49_242460   mitochondrial carrier superfamily protein
Theileria parva TP03_0431   hypothetical protein

Essentiality

PF3D7_1241600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.14280 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.14280 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.14280 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.14280 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1455000 Plasmodium berghei Essential plasmo
TGME49_242460 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier PF3D7_1241600 (Plasmodium falciparum), mitochondrial carrier protein, putative
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