Detailed view for PF3D7_1243000

Basic information

TDR Targets ID: 5468
Plasmodium falciparum, syntaxin, Qa-SNARE family
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.5123 | Length (AA): 302 | MW (Da): 35810 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0005484   SNAP receptor activity  
GO:0016020   membrane  
GO:0005515   protein binding  
GO:0016192   vesicle-mediated transport  
GO:0006886   intracellular protein transport  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
211 269 1gl2 (B) 169 227 25.00 0.0000048 0.02 0.5 -0.87
1 178 4tql (A) 23 197 21.00 0.29 0.86 0.808204 -0.41
57 172 3lg7 (A) 1 118 12.00 0.058 0.18 0.643806 -1.54
66 149 2wps (A) 459 553 36.00 0.64 0.03 0.415946 0.37
218 277 2nps (B) 189 248 28.00 0.29 0.05 0.465075 -0.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 32 hs, gametocyte, early schizont, late schizont, Female Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early trophozoite, late trophozoite, Oocyst, Sporozoite, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Ring. Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127496)

Species Accession Gene Product
Arabidopsis thaliana AT5G26980   syntaxin-41
Arabidopsis thaliana AT3G05710   syntaxin-43
Arabidopsis thaliana AT4G02195   syntaxin-42
Babesia bovis BBOV_II002810   t-SNARE protein, putative
Brugia malayi Bm1_12930   SNARE domain containing protein
Brugia malayi Bm1_05385   SNARE domain containing protein
Candida albicans CaO19.1538   similar to syntaxin
Candida albicans CaO19.9112   similar to syntaxin
Caenorhabditis elegans CELE_ZC155.7   Protein SYX-16
Cryptosporidium hominis Chro.50300   hypothetical protein
Cryptosporidium parvum cgd5_870   hypothetical protein
Dictyostelium discoideum DDB_G0276469   t-SNARE family protein
Dictyostelium discoideum DDB_G0276515   hypothetical protein
Dictyostelium discoideum DDB_G0276575   t-SNARE family protein
Drosophila melanogaster Dmel_CG1467   Syntaxin 16
Echinococcus granulosus EgrG_000188600   syntaxin 16
Entamoeba histolytica EHI_148750   syntaxin, putative
Entamoeba histolytica EHI_164320   syntaxin, putative
Echinococcus multilocularis EmuJ_000188600   syntaxin 16
Giardia lamblia GL50803_3869   Syntaxin 16
Homo sapiens ENSG00000124222   syntaxin 16
Leishmania braziliensis LbrM.34.2610   QA-SNARE protein putative
Leishmania donovani LdBPK_352760.1   QA-SNARE protein putative
Leishmania infantum LinJ.35.2760   QA-SNARE protein putative
Leishmania major LmjF.35.2720   QA-SNARE protein putative
Leishmania mexicana LmxM.34.2720   QA-SNARE protein putative
Loa Loa (eye worm) LOAG_10797   SNARE domain-containing protein
Mus musculus ENSMUSG00000027522   syntaxin 16
Neospora caninum NCLIV_064030   CBR-SYN-16 protein, related
Oryza sativa 4339929   Os06g0116300
Plasmodium berghei PBANKA_1456400   SNARE protein, putative
Plasmodium falciparum PF3D7_1243000   syntaxin, Qa-SNARE family
Plasmodium knowlesi PKNH_1462300   t-SNARE, putative
Plasmodium vivax PVX_101050   t-SNARE, putative
Plasmodium yoelii PY03571   hypothetical protein
Saccharomyces cerevisiae YOL018C   Tlg2p
Schistosoma japonicum Sjp_0091300   ko:K08489 syntaxin 16, putative
Schistosoma mansoni Smp_138840   syntaxin
Schistosoma mansoni Smp_191760   syntaxin
Schmidtea mediterranea mk4.001285.02  
Schmidtea mediterranea mk4.001285.03  
Trypanosoma brucei gambiense Tbg972.9.8030   syntaxin, putative
Trypanosoma brucei Tb927.9.13030   QA-SNARE protein putative
Trypanosoma congolense TcIL3000_9_5480   QA-SNARE protein putative
Trypanosoma cruzi TcCLB.508465.120   syntaxin, putative
Trypanosoma cruzi TcCLB.507001.70   syntaxin, putative
Toxoplasma gondii TGME49_247930   SNARE domain-containing protein
Theileria parva TP04_0386   hypothetical protein
Trichomonas vaginalis TVAG_256730   syntaxin, putative
Trichomonas vaginalis TVAG_316110   syntaxin, putative
Trichomonas vaginalis TVAG_315270   syntaxin, putative
Trichomonas vaginalis TVAG_188050   syntaxin-16, putative

Essentiality

PF3D7_1243000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.3920 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.3920 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.3920 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.3920 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1456400 Plasmodium berghei Essential plasmo
TGME49_247930 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier PF3D7_1243000 (Plasmodium falciparum), syntaxin, Qa-SNARE family
Title for this comment
Comment