Detailed view for Tbg972.10.13260

Basic information

TDR Targets ID: 547435
Trypanosoma brucei gambiense, Heat shock protein 83, putative

Source Database / ID: 

pI: 4.8119 | Length (AA): 704 | MW (Da): 80777 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00183   Hsp90 protein
PF02518   Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

Gene Ontology

Mouse over links to read term descriptions.
GO:0051082   unfolded protein binding  
GO:0005524   ATP binding  
GO:0006950   response to stress  
GO:0006457   protein folding  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126623)

Species Accession Gene Product
Arabidopsis thaliana AT5G56030   heat shock protein 81-2
Arabidopsis thaliana AT2G04030   chloroplast heat shock protein 90
Arabidopsis thaliana AT5G52640   heat shock protein 90.1
Arabidopsis thaliana AT5G56000   Heat shock protein 90-4
Arabidopsis thaliana AT3G07770   HEAT SHOCK PROTEIN 89.1
Arabidopsis thaliana AT5G56010   Heat shock protein 90-3
Arabidopsis thaliana AT4G24190   HSP90-like protein GRP94
Babesia bovis BBOV_III004230   hsp90 protein
Brugia malayi Bm1_51495   heat shock protein 90
Brugia malayi Bm1_39715   Endoplasmin precursor
Candida albicans CaO19.13868   heat shock protein
Candida albicans CaO19_6515   hypothetical protein
Candida albicans CaO19.6515   heat shock protein
Caenorhabditis elegans CELE_T05E11.3   Protein ENPL-1, isoform B
Caenorhabditis elegans CELE_C47E8.5   Protein DAF-21
Cryptosporidium hominis Chro.30427   heat shock protein 83
Cryptosporidium parvum cgd3_3770   Hsp90
Dictyostelium discoideum DDB_G0280057   heat shock protein Hsp90 family protein
Dictyostelium discoideum DDB_G0267400   heat shock protein Hsp90 family protein
Drosophila melanogaster Dmel_CG1242   Heat shock protein 83
Drosophila melanogaster Dmel_CG5520   Glycoprotein 93
Escherichia coli b0473   protein refolding molecular co-chaperone Hsp90, Hsp70-dependent
Echinococcus granulosus EgrG_000723800   heat shock protein 90
Echinococcus granulosus EgrG_000918050   heat shock protein 90
Echinococcus granulosus EgrG_001043900   endoplasmin
Echinococcus granulosus EgrG_000008700   heat shock protein heat shock protein 90 alpha
Echinococcus granulosus EgrG_000679700   heat shock protein
Entamoeba histolytica EHI_102270   heat shock protein 90, putative
Entamoeba histolytica EHI_196940   heat shock protein 90, putative
Echinococcus multilocularis EmuJ_000723800   heat shock protein 90
Echinococcus multilocularis EmuJ_000008700   heat shock protein 90
Echinococcus multilocularis EmuJ_000679700   heat shock protein
Echinococcus multilocularis EmuJ_001043900   endoplasmin
Giardia lamblia GL50803_13864   Heat shock protein HSP 90-alpha
Giardia lamblia GL50803_15247   Grp94/Hsp90
Giardia lamblia GL50803_98054   Heat shock protein HSP 90-alpha
Homo sapiens ENSG00000096384   heat shock protein 90kDa alpha (cytosolic), class B member 1
Homo sapiens ENSG00000080824   heat shock protein 90kDa alpha (cytosolic), class A member 1
Homo sapiens ENSG00000166598   heat shock protein 90kDa beta (Grp94), member 1
Leishmania braziliensis LbrM.33.0340   heat shock protein 83-1
Leishmania braziliensis LbrM.33.0350   heat shock protein 83-1
Leishmania braziliensis LbrM.29.0780   lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative
Leishmania braziliensis LbrM.33.0330   heat shock protein 83-1
Leishmania donovani LdBPK_290790.1   heat shock protein 90, putative
Leishmania donovani LdBPK_330360.1   heat shock protein 83-1
Leishmania infantum LinJ.29.0790   lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative
Leishmania infantum LinJ.33.0350   heat shock protein 83-1
Leishmania infantum LinJ.33.0360   heat shock protein 83-1
Leishmania infantum LinJ.33.0370   heat shock protein 83-1
Leishmania major LmjF.33.0360   heat shock protein 83-1
Leishmania major LmjF.33.0355   heat shock protein 83-1
Leishmania major LmjF.33.0314   heat shock protein 83-1
Leishmania major LmjF.33.0316   heat shock protein 83-1
Leishmania major LmjF.33.0336   heat shock protein 83-1
Leishmania major LmjF.33.0320   heat shock protein 83-1
Leishmania major LmjF.33.0318   heat shock protein 83-1
Leishmania major LmjF.33.0343   heat shock protein 83-1
Leishmania major LmjF.33.0350   heat shock protein 83-1
Leishmania major LmjF.33.0365   heat shock protein 83-1
Leishmania major LmjF.33.0333   heat shock protein 83-1
Leishmania major LmjF.33.0323   heat shock protein 83-1
Leishmania major LmjF.33.0340   heat shock protein 83-1
Leishmania major LmjF.29.0760   lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative
Leishmania major LmjF.33.0330   heat shock protein 83-1
Leishmania major LmjF.33.0312   heat shock protein 83-1
Leishmania major LmjF.33.0326   heat shock protein 83-1
Leishmania major LmjF.33.0346   heat shock protein 83-1
Leishmania mexicana LmxM.32.0312   heat shock protein 83-1
Leishmania mexicana LmxM.08_29.0760   lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative
Leishmania mexicana LmxM.32.0314   heat shock protein 83-1
Loa Loa (eye worm) LOAG_04661   endoplasmin
Loa Loa (eye worm) LOAG_00073   heat shock protein 90
Mycobacterium leprae ML1623   PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)
Mus musculus ENSMUSG00000023944   heat shock protein 90 alpha (cytosolic), class B member 1
Mus musculus ENSMUSG00000020048   heat shock protein 90, beta (Grp94), member 1
Mus musculus ENSMUSG00000021270   heat shock protein 90, alpha (cytosolic), class A member 1
Mycobacterium tuberculosis Rv2299c   Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)
Mycobacterium ulcerans MUL_2744   heat shock protein 90
Neospora caninum NCLIV_040880   HSP90, related
Neospora caninum NCLIV_019110   HSP90-like protein, related
Oryza sativa 9267802   Os09g0482610
Oryza sativa 4347405   Os09g0482400
Oryza sativa 4345951   Os08g0500700
Oryza sativa 4347402   Os09g0482100
Oryza sativa 4352339   Os12g0514500
Oryza sativa 4345893   Os08g0487800
Oryza sativa 4342077   Os06g0716700
Oryza sativa 4347356   Os09g0474300
Oryza sativa 9267997   Os04g0107900
Oryza sativa 9268423   Os09g0482300
Plasmodium berghei PBANKA_0805700   heat shock protein 90, putative
Plasmodium falciparum PF3D7_0708400   heat shock protein 90
Plasmodium knowlesi PKNH_1441400   endoplasmin, putative
Plasmodium knowlesi PKNH_0107000   heat shock protein 90, putative
Plasmodium vivax PVX_123745   endoplasmin, putative
Plasmodium vivax PVX_087950   heat shock protein 86, putative
Plasmodium yoelii PY00131   putative heat shock protein 81-2
Plasmodium yoelii PY00582   heat shock protein 90
Plasmodium yoelii PY00130   heat shock 90 kDa protein homolog
Saccharomyces cerevisiae YPL240C   Hsp90 family chaperone HSP82
Saccharomyces cerevisiae YMR186W   Hsp90 family chaperone HSC82
Schistosoma japonicum Sjp_0012130   IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing
Schistosoma japonicum Sjp_0309120   Heat shock protein HSP 90-alpha, putative
Schistosoma japonicum Sjp_0044660   ko:K04079 molecular chaperone HtpG, putative
Schistosoma japonicum Sjp_0007330   Heat shock protein 83, putative
Schistosoma japonicum Sjp_0012140   ko:K09487 heat shock protein 90kDa beta, putative
Schistosoma japonicum Sjp_0044670   Heat shock protein HSP 90-beta, putative
Schistosoma mansoni Smp_072330.2   heat shock protein
Schistosoma mansoni Smp_030300.4   endoplasmin
Schistosoma mansoni Smp_072330.1   heat shock protein
Schistosoma mansoni Smp_030300.3   endoplasmin
Schmidtea mediterranea mk4.007838.01   Heat shock protein 90
Schmidtea mediterranea mk4.017134.00  
Schmidtea mediterranea mk4.005886.00  
Schmidtea mediterranea mk4.007212.00   Heat shock protein 90
Schmidtea mediterranea mk4.027122.01   Heat shock protein 90
Schmidtea mediterranea mk4.017444.01   Heat shock protein 90
Schmidtea mediterranea mk4.034899.00   Heat shock protein 90
Schmidtea mediterranea mk4.001495.06  
Schmidtea mediterranea mk4.019240.04   Heat shock protein 90
Schmidtea mediterranea mk4.002547.00   Heat shock protein 90
Schmidtea mediterranea mk4.001015.04   Heat shock protein 90
Schmidtea mediterranea mk4.008399.00   Heat shock protein 90
Schmidtea mediterranea mk4.019297.00   Heat shock protein 90
Schmidtea mediterranea mk4.000497.11   Heat shock protein 90
Schmidtea mediterranea mk4.001850.04   Heat shock protein 90
Schmidtea mediterranea mk4.021028.00   Heat shock protein 90
Schmidtea mediterranea mk4.003841.01   Heat shock protein 90
Schmidtea mediterranea mk4.005511.02   Heat shock protein 90
Schmidtea mediterranea mk4.001354.04  
Schmidtea mediterranea mk4.019819.00  
Schmidtea mediterranea mk4.000032.21   Endoplasmin
Schmidtea mediterranea mk4.017004.00  
Schmidtea mediterranea mk4.014745.00   Heat shock protein 90
Schmidtea mediterranea mk4.002761.01  
Schmidtea mediterranea mk4.008769.00   Heat shock protein 90
Schmidtea mediterranea mk4.009930.00   Putative thrombospondin
Schmidtea mediterranea mk4.003186.09   Heat shock protein 90
Schmidtea mediterranea mk4.001450.11   Heat shock protein 90
Schmidtea mediterranea mk4.020174.00   Heat shock protein 90
Schmidtea mediterranea mk4.008725.01   Heat shock protein 90
Schmidtea mediterranea mk4.012604.00   Heat shock protein 90
Schmidtea mediterranea mk4.000245.17  
Schmidtea mediterranea mk4.000286.14   Heat shock protein 90
Schmidtea mediterranea mk4.034713.00  
Schmidtea mediterranea mk4.014783.00   Heat shock protein 90
Schmidtea mediterranea mk4.005289.00  
Schmidtea mediterranea mk4.005595.02   Heat shock protein 90
Schmidtea mediterranea mk4.003321.03  
Schmidtea mediterranea mk4.025031.00  
Schmidtea mediterranea mk4.015137.00   Heat shock protein 90
Schmidtea mediterranea mk4.004356.02   Heat shock protein 90
Schmidtea mediterranea mk4.013118.00   Heat shock protein 90
Schmidtea mediterranea mk4.001147.04   Heat shock protein 90
Schmidtea mediterranea mk4.010175.00   Heat shock protein 90
Schmidtea mediterranea mk4.008904.00   Heat shock protein 90
Schmidtea mediterranea mk4.001025.00   Heat shock protein 90
Schmidtea mediterranea mk4.006109.03  
Schmidtea mediterranea mk4.001553.04  
Schmidtea mediterranea mk4.017122.01   Heat shock protein 90
Schmidtea mediterranea mk4.035456.00  
Schmidtea mediterranea mk4.002875.05   Heat shock protein 90
Schmidtea mediterranea mk4.034823.00   Heat shock protein 90
Schmidtea mediterranea mk4.000023.24   Heat shock protein 90
Schmidtea mediterranea mk4.000326.07  
Schmidtea mediterranea mk4.056471.01   Heat shock protein 90
Schmidtea mediterranea mk4.017077.00   Heat shock protein 90
Schmidtea mediterranea mk4.019496.00  
Schmidtea mediterranea mk4.029467.00  
Schmidtea mediterranea mk4.002464.00  
Schmidtea mediterranea mk4.002389.02   Heat shock protein 90
Schmidtea mediterranea mk4.007949.03  
Schmidtea mediterranea mk4.003252.01   Heat shock protein 90
Schmidtea mediterranea mk4.000729.14   Heat shock protein 90
Schmidtea mediterranea mk4.005831.00   Heat shock protein 90
Schmidtea mediterranea mk4.016373.00   Heat shock protein 90
Schmidtea mediterranea mk4.015857.00   Heat shock protein 90
Schmidtea mediterranea mk4.023244.02   Heat shock protein 90
Schmidtea mediterranea mk4.008721.05   Heat shock protein 90
Schmidtea mediterranea mk4.008241.02   Heat shock protein 90
Trypanosoma brucei gambiense Tbg972.3.3850   lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative
Trypanosoma brucei gambiense Tbg972.10.13280   heat shock protein 83,heat shock protein
Trypanosoma brucei gambiense Tbg972.10.13260   Heat shock protein 83, putative
Trypanosoma brucei gambiense Tbg972.10.13270   Heat shock protein 83, putative
Trypanosoma brucei Tb11.v5.0543   Heat shock protein 83, putative
Trypanosoma brucei Tb927.10.10950   heat shock protein, putative
Trypanosoma brucei Tb927.10.10960   heat shock protein, putative
Trypanosoma brucei Tb927.10.10900   heat shock protein, putative
Trypanosoma brucei Tb927.10.10940   heat shock protein, putative
Trypanosoma brucei Tb927.10.10910   heat shock protein, putative
Trypanosoma brucei Tb927.10.10920   heat shock protein, putative
Trypanosoma brucei Tb927.10.10980   heat shock protein 90, putative
Trypanosoma brucei Tb927.10.10970   heat shock protein, putative
Trypanosoma brucei Tb927.3.3580   heat shock protein 90, putative
Trypanosoma brucei Tb927.10.10930   heat shock protein, putative
Trypanosoma congolense TcIL3000_0_48690   heat shock protein 90, putative
Trypanosoma congolense TcIL3000_0_26140   Heat shock protein 83, putative
Trypanosoma congolense TcIL3000_3_2270   heat shock protein 90, putative
Trypanosoma cruzi TcCLB.509643.130   heat shock protein 85, putative
Trypanosoma cruzi TcCLB.506989.190   heat shock protein 90, putative
Trypanosoma cruzi TcCLB.509105.140   heat shock protein 85, putative
Trypanosoma cruzi TcCLB.506591.4   heat shock protein 90, putative
Trypanosoma cruzi TcCLB.507713.30   heat shock protein 85, putative
Trypanosoma cruzi TcCLB.509105.150   heat shock protein 85, putative
Trypanosoma cruzi TcCLB.503811.10   heat shock protein 90, putative
Trypanosoma cruzi TcCLB.509643.139   Heat shock protein 83, putative
Toxoplasma gondii TGME49_244560   heat shock protein 90, putative
Toxoplasma gondii TGME49_288380   heat shock protein HSP90
Treponema pallidum TP0984   heat shock protein 90
Theileria parva TP02_0244   heat shock protein 90
Trichomonas vaginalis TVAG_153560   heat shock protein, putative
Trichomonas vaginalis TVAG_378910   heat shock protein, putative
Trichomonas vaginalis TVAG_030810   heat shock protein, putative
Trichomonas vaginalis TVAG_034720   heat shock protein, putative
Wolbachia endosymbiont of Brugia malayi Wbm0138   heat shock protein 90

Essentiality

Tbg972.10.13260 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2334 Mycobacterium tuberculosis non-essential nmpdr
Tb927.10.10980 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.10980 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.10980 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.10980 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.3.3580 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.3580 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.3580 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.3.3580 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
b0473 Escherichia coli non-essential goodall
CELE_C47E8.5 Caenorhabditis elegans embryonic lethal wormbase
CELE_C47E8.5 Caenorhabditis elegans larval arrest wormbase
CELE_C47E8.5 Caenorhabditis elegans larval lethal wormbase
CELE_C47E8.5 Caenorhabditis elegans slow growth wormbase
CELE_C47E8.5 Caenorhabditis elegans sterile wormbase
CELE_T05E11.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_T05E11.3 Caenorhabditis elegans larval arrest wormbase
CELE_T05E11.3 Caenorhabditis elegans larval lethal wormbase
CELE_T05E11.3 Caenorhabditis elegans slow growth wormbase
CELE_T05E11.3 Caenorhabditis elegans sterile wormbase
PBANKA_0805700 Plasmodium berghei Slow plasmo
TGME49_288380 Toxoplasma gondii Probably essential sidik
TGME49_244560 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Candida albicans hypothetical protein Compounds References
Homo sapiens heat shock protein 90kDa beta (Grp94), member 1 Compounds References
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Compounds References
Sus scrofa Endoplasmin Compounds References
Saccharomyces cerevisiae Hsp90 family chaperone HSP82 Compounds References
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class B member 1 Compounds References
Oryctolagus cuniculus Heat shock protein HSP 90 Compounds References
Canis lupus familiaris Heat shock protein 90 beta Compounds References
Mus musculus heat shock protein 90, alpha (cytosolic), class A member 1 Compounds References
Saccharomyces cerevisiae Hsp90 family chaperone HSC82 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Tbg972.10.13260 (Trypanosoma brucei gambiense), Heat shock protein 83, putative
Title for this comment
Comment