Detailed view for TcCLB.507709.90

Basic information

TDR Targets ID: 54985
Trypanosoma cruzi, sterol C-24 reductase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.2207 | Length (AA): 488 | MW (Da): 57809 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01222   Ergosterol biosynthesis ERG4/ERG24 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  

Metabolic Pathways

Steroid biosynthesis (KEGG)
Global map (KEGG)
Biosynthesis of antibiotics (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
69 362 1v54 (A) 182 464 12.00 0 0.01 0.61 -0.63
59 488 4quv (A) 23 427 32.00 0 0.96 1.13785 0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Smircich P
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile epimastigote. Smircich P
Show/Hide expression data references
  • Smircich P Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi.

Orthologs

Ortholog group members (OG5_132400)

Species Accession Gene Product
Candida albicans CaO19.5379   similar to S. cerevisiae sterol C-24 (28) reductase ERG4 (YGL012W) involved in ergosterol biosynthesis
Candida albicans CaO19.12834   similar to S. cerevisiae sterol C-24 (28) reductase ERG4 (YGL012W) involved in ergosterol biosynthesis
Leishmania braziliensis LbrM.33.0720   sterol C-24 reductase, putative
Leishmania donovani LdBPK_330730.1   sterol C-24 reductase, putative
Leishmania infantum LinJ.33.0730   sterol C-24 reductase, putative
Leishmania major LmjF.33.0680   sterol C-24 reductase, putative
Leishmania mexicana LmxM.32.0680   sterol C-24 reductase, putative
Saccharomyces cerevisiae YGL012W   delta(24(24(1)))-sterol reductase
Trypanosoma cruzi TcCLB.506577.120   sterol C-24 reductase, putative
Trypanosoma cruzi TcCLB.507709.90   sterol C-24 reductase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus 7-dehydrocholesterol reductase 471 aa 26.7% 453 aa Compounds References
Zea mays Delta(14)-sterol reductase 370 aa 27.5% 367 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier TcCLB.507709.90 (Trypanosoma cruzi), sterol C-24 reductase, putative
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