Detailed view for TcIL3000_10_6890

Basic information

TDR Targets ID: 550153
Trypanosoma congolense, prolyl endopeptidase
Source Database / ID: 

pI: 5.9402 | Length (AA): 698 | MW (Da): 77927 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00326   Prolyl oligopeptidase family
PF02897   Prolyl oligopeptidase, N-terminal beta-propeller domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0070008   GO:serine-type exopeptidase activity  

GO:0008236   serine-type peptidase activity  
GO:0004252   serine-type endopeptidase activity  
GO:0006508   proteolysis  

Metabolic Pathways

Renin-angiotensin system (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 697 2xdw (A) 2 709 45.00 0 1 1.58577 -0.9

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129295)

Species Accession Gene Product
Arabidopsis thaliana AT1G20380   Prolyl oligopeptidase family protein
Arabidopsis thaliana AT1G76140   prolyl oligopeptidase
Brugia malayi Bm1_13815   prolyl oligopeptidase family protein
Dictyostelium discoideum DDB_G0274387   prolyl oligopeptidase
Drosophila melanogaster Dmel_CG2528   CG2528 gene product from transcript CG2528-RE
Drosophila melanogaster Dmel_CG5355   CG5355 gene product from transcript CG5355-RA
Echinococcus granulosus EgrG_000668800   prolyl endopeptidase
Echinococcus multilocularis EmuJ_000668800   prolyl endopeptidase
Homo sapiens ENSG00000085377   prolyl endopeptidase
Leishmania donovani LdBPK_367060.1   prolyl endopeptidase
Leishmania infantum LinJ.36.7060   prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative
Leishmania major LmjF.36.6750   prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative
Leishmania mexicana LmxM.36.6750   prolyl oligopeptidase, putative
Loa Loa (eye worm) LOAG_02157   hypothetical protein
Mus musculus ENSMUSG00000019849   prolyl endopeptidase
Mycobacterium tuberculosis Rv0781   Probable protease II PtrBa [first part] (oligopeptidase B)
Neospora caninum NCLIV_014330   Prolyl oligopeptidase (EC 3.4.21.26) (Precursor), related
Oryza sativa 4336657   Os04g0561500
Oryza sativa 4326161   Os01g0108200
Onchocerca volvulus OVOC1887   Prolyl endopeptidase homolog
Schistosoma japonicum Sjp_0016510   Prolyl endopeptidase, putative
Schistosoma japonicum Sjp_0080730   ko:K01322 prolyl oligopeptidase [EC3.4.21.26], putative
Schistosoma mansoni Smp_011590.1   prolyl oligopeptidase (S09 family)
Schistosoma mansoni Smp_011590.2   prolyl oligopeptidase (S09 family)
Schmidtea mediterranea mk4.001166.08  
Schmidtea mediterranea mk4.047032.00  
Trypanosoma brucei gambiense Tbg972.10.9810   prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative
Trypanosoma brucei Tb927.10.8020   prolyl endopeptidase
Trypanosoma congolense TcIL3000_10_6890   prolyl endopeptidase
Trypanosoma cruzi TcCLB.506247.230   prolyl endopeptidase
Toxoplasma gondii TGME49_286120   prolyl endopeptidase

Essentiality

TcIL3000_10_6890 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Mycobacterium tuberculosis essential nmpdr
Tb927.10.8020 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.8020 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.8020 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.8020 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_286120 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Prolyl endopeptidase Compounds References
Mus musculus prolyl endopeptidase Compounds References
Trypanosoma cruzi prolyl endopeptidase Compounds References
Elizabethkingia meningoseptica Prolyl endopeptidase Compounds References
Bos taurus Prolyl endopeptidase Compounds References
Rattus norvegicus Prolyl endopeptidase Compounds References
Homo sapiens prolyl endopeptidase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier TcIL3000_10_6890 (Trypanosoma congolense), prolyl endopeptidase
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