Detailed view for PF3D7_1247400

Basic information

TDR Targets ID: 5509
Plasmodium falciparum, peptidyl-prolyl cis-trans isomerase FKBP35

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.1286 | Length (AA): 304 | MW (Da): 34827 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00254   FKBP-type peptidyl-prolyl cis-trans isomerase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0005528   FK506 binding  
GO:0005515   protein binding  
GO:0005488   binding  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 297 1kt1 (A) 136 420 28.00 0 1 1.28 0.19
128 280 2fbn (A) 22 174 99.99 0 1 1.77 -1.75
194 259 2avp (A) 1 66 36.00 0 1 0.87 -2.01
4 127 3ni6 (A) 3 126 80.00 0 1 1.46429 -1.64
6 297 1kt1 (A) 136 420 24.00 0.0000000031 1 1.20623 0.56
128 280 2fbn (A) 22 174 99.99 0 1 1.73169 -1.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 2FBN:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2KI3:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2OFN:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2VN1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3IHZ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4J4N:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QT2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4QT3:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, gametocyte, merozoite, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_126727)

Species Accession Gene Product
Arabidopsis thaliana AT3G25230   rotamase FKBP 1
Arabidopsis thaliana AT5G45680   peptidyl-prolyl cis-trans isomerase FKBP13
Arabidopsis thaliana AT5G48570   peptidyl-prolyl cis-trans isomerase FKBP65
Brugia malayi Bm1_49010   FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12
Brugia malayi Bm1_56870   FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59
Candida albicans CaO19_6452   hypothetical protein
Candida albicans CaO19.13810   one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes
Candida albicans CaO19.3702   one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes
Candida albicans CaO19.11186   one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes
Candida albicans CaO19.6452   one of two identical potential FKBP-type peptidyl-prolyl cis-trans isomerase genes
Caenorhabditis elegans CELE_F31D4.3   Protein FKB-6
Caenorhabditis elegans CELE_Y18D10A.19   Protein FKB-2
Dictyostelium discoideum DDB_G0283815   hypothetical protein
Dictyostelium discoideum DDB_G0275227   FKBP-type peptidylprolyl cis-trans isomerase
Drosophila melanogaster Dmel_CG11001   FK506-binding protein 2
Drosophila melanogaster Dmel_CG4535   FK506-binding protein FKBP59
Echinococcus granulosus EgrG_001185900   peptidyl prolyl cis trans isomerase FKBP4
Echinococcus granulosus EgrG_001186200   peptidyl prolyl cis trans isomerase FKBP4
Echinococcus granulosus EgrG_000334550   peptidyl prolyl cis trans isomerase FKBP1A
Entamoeba histolytica EHI_051870   peptidyl-prolyl cis-trans isomerase, FKBP-type , putative
Entamoeba histolytica EHI_178850   peptidyl-prolyl cis-trans isomerase, FKBP-type, putative
Echinococcus multilocularis EmuJ_001186200   peptidyl prolyl cis trans isomerase FKBP4
Echinococcus multilocularis EmuJ_000334550   fk506 binding protein
Echinococcus multilocularis EmuJ_001185900   peptidyl prolyl cis trans isomerase FKBP4
Giardia lamblia GL50803_10450   FKBP-type peptidyl-prolyl cis-trans isomerase
Giardia lamblia GL50803_3643   70 kDa peptidylprolyl isomerase, putative
Homo sapiens ENSG00000096060   FK506 binding protein 5
Homo sapiens ENSG00000004478   FK506 binding protein 4, 59kDa
Homo sapiens ENSG00000119782   FK506 binding protein 1B, 12.6 kDa
Homo sapiens ENSG00000088832   FK506 binding protein 1A, 12kDa
Leishmania braziliensis LbrM.19.1790   peptidylprolyl isomerase-like protein
Leishmania braziliensis LbrM.22.1310   fk506-binding protein 1-like protein
Leishmania donovani LdBPK_191560.1   peptidylprolyl isomerase-like protein
Leishmania donovani LdBPK_221280.1   fk506-binding protein 1-like protein
Leishmania infantum LinJ.19.1560   peptidylprolyl isomerase-like protein
Leishmania infantum LinJ.22.1280   fk506-binding protein 1-like protein
Leishmania major LmjF.19.1530   peptidylprolyl isomerase-like protein
Leishmania major LmjF.22.1430   fk506-binding protein 1-like protein
Leishmania mexicana LmxM.22.1430   fk506-binding protein 1-like protein
Leishmania mexicana LmxM.19.1530   peptidylprolyl isomerase-like protein
Loa Loa (eye worm) LOAG_03265   FKBP5 protein
Loa Loa (eye worm) LOAG_13106   hypothetical protein
Loa Loa (eye worm) LOAG_02491   FKBP-type peptidyl-prolyl cis-trans isomerase-12
Mus musculus ENSMUSG00000024222   FK506 binding protein 5
Mus musculus ENSMUSG00000032966   FK506 binding protein 1a
Mus musculus ENSMUSG00000020635   FK506 binding protein 1b
Mus musculus ENSMUSG00000030357   FK506 binding protein 4
Mycobacterium ulcerans MUL_2502   FK-506 binding protein, peptidyl-prolyl cis-trans isomerase
Neospora caninum NCLIV_028870   Peptidylprolyl isomerase D (Cyclophilin D), related
Oryza sativa 4329388   Os02g0491400
Oryza sativa 4335556   Os04g0352400
Oryza sativa 4341766   Os06g0663800
Oryza sativa 4346090   Os08g0525600
Plasmodium berghei PBANKA_1460400   peptidyl-prolyl cis-trans isomerase FKBP35, putative
Plasmodium falciparum PF3D7_1247400   peptidyl-prolyl cis-trans isomerase FKBP35
Plasmodium knowlesi PKNH_1467100   peptidyl-prolyl cis-trans isomerase FKBP35, putative
Plasmodium vivax PVX_101260   70 kDa peptidylprolyl isomerase, putative
Plasmodium yoelii PY02360   FK506-binding protein
Saccharomyces cerevisiae YNL135C   peptidylprolyl isomerase FPR1
Schistosoma japonicum Sjp_0025140   ko:K09568 FK506-binding protein 1, putative
Schistosoma japonicum Sjp_0127020   FK506-binding protein 1A, putative
Schistosoma japonicum Sjp_0016730   ko:K09571 FK506-binding protein 4/5, putative
Schistosoma mansoni Smp_079230   immunophilin FK506 binding protein FKBP12
Schistosoma mansoni Smp_004780.1   immunophilin
Schistosoma mansoni Smp_004780.3   immunophilin
Schistosoma mansoni Smp_004780.2   immunophilin
Schmidtea mediterranea mk4.002275.03   Peptidyl-prolyl cis-trans isomerase
Schmidtea mediterranea mk4.002452.06   Peptidyl-prolyl cis-trans isomerase
Schmidtea mediterranea mk4.054209.00   39 kDa FK506-binding nuclear protein
Schmidtea mediterranea mk4.000763.00   Peptidyl prolyl cis trans isomerase FKBP-1
Trypanosoma brucei gambiense Tbg972.10.19710   peptidylprolyl isomerase-like protein, putative
Trypanosoma brucei gambiense Tbg972.7.3750   peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma brucei Tb927.7.3420   peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma brucei Tb927.10.16100   FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative
Trypanosoma congolense TcIL3000_0_03850   FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative
Trypanosoma congolense TcIL3000_7_2670   peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma cruzi TcCLB.508323.84   peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma cruzi TcCLB.511353.10   FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative
Trypanosoma cruzi TcCLB.511825.63   peptidyl-prolyl cis-trans isomerase, putative
Trypanosoma cruzi TcCLB.511301.70   FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative
Treponema pallidum TP0862   peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)
Theileria parva TP02_0901   peptidyl-prolyl cis-trans isomerase, putative
Trichomonas vaginalis TVAG_413760   fk506-binding protein, putative
Trichomonas vaginalis TVAG_292580   immunophilin, putative
Trichomonas vaginalis TVAG_476140   peptidylprolyl isomerase, putative
Trichomonas vaginalis TVAG_368970   peptidylprolyl isomerase, putative

Essentiality

PF3D7_1247400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.3420 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.7.3420 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.3420 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.7.3420 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Tb927.10.16100 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.16100 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.16100 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.10.16100 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F31D4.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_F31D4.3 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Rattus norvegicus FK506-binding protein 1A Compounds References
Homo sapiens FK506 binding protein 5 Compounds References
Homo sapiens FK506 binding protein 1B, 12.6 kDa Compounds References
Homo sapiens FK506 binding protein 1A, 12kDa Compounds References
Homo sapiens FK506 binding protein 4, 59kDa Compounds References
Legionella pneumophila Outer membrane protein MIP Compounds References
Gallus gallus FK506 binding protein 12 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.1565 0.9901 1
0.1334 0.9886 1
0.1997 0.9987 1
0.021875 0.42247 1
0.1768 0.484 1
0.0575 0.9775 1
0.0065 0.4026 0.5
0.1565 1 0.5
0.1151 0.3118 1
0.025 0.2973 0.5
0.0881 1 0.5
0.0461 0.6288 1
0.0231 1 0.5
0.0065 1 1
0.0084 0.2968 1
0.0331 0.3716 1
0.0182 0.2929 1
0.136 0.8497 1
0.1607 0.2653 1
0.0225 0.5436 1
0.1294 0.2898 0.4889
0.0126 0.2904 1
0.1522 0.5241 1
0.0244 1 1
0.0744 1 0.5
0.1293 0.7469 1
0.0629 0.7093 1
0.0481 0.6014 1
0.0098 0.9833 0.5
0.0755 0.8084 0.5
0.1327 0.9982 1
0.0065 0.5731 0.5
0.0163 0.5222 1
0.1214 0.7931 1
0.2008 0.9987 1
0.1487 0.9984 1
0.2547 0.9989 1
0.0033 0.9498 0.5
0.0739 0.3937 1
0.0347 1 0.5
0.0288 0.396 1
0.0443 0.6535 1
0.0065 0.3009 0.2675
0.0415 0.9846 1
0.0184 0.485 0.5
0.0807 0.3103 0.7757
0.0661 0.9884 1
0.042 0.4099 1
0.0602 1 1
0.0575 0.4975 1
0.00428991 1 0.5
0.0233 0.308 1
0.0807 0.3103 0.7757
0.0163 0.4295 1
0.0059 0.5303 1
0.0807 0.3103 0.7757
0.0572 1 1
0.158 0.2763 1
0.2626 0.9873 1
0.0931 0.4554 1
0.0653 0.3174 1
0.0756 0.8513 1
0.0224 0.2691 1
0.0214 0.2801 1
0.0151 0.5866 1
0.0216 1 0.5
0.0554 0.7946 1
0.1596 0.2743 1
0.1813 0.9986 1
0.0754 0.5927 1
0.013 0.5583 1
0.175 0.9815 1
0.0443 0.6535 1
0.0053 0.288 1
0.2572 0.3315 0.9822
0.0098 0.9833 0.5
0.068 0.2566 1
0.0065 0.3923 0.5
0.1747 0.8768 1
0.0755 0.8435 1
0.0487 1 1
0.1404 0.9991 1
0.0157 0.9901 0.5
0.0649 1 1
0.0842 0.3697 1
0.033 0.98 1
0.1299 0.5192 1
0.078 0.9351 1
0.0927 0.9777 1
0.1618 0.9985 1
0.1149 0.2629 1
0.0402 1 1
0.0112 1 1
0.0187 0.3494 1
0.0099 0.4701 1
0.0098 0.9833 0.5
0.3261 0.6474 1
0.0913 0.2536 1
0.0879 0.5083 1
0.0065 1 0.5
0.0255 0.3334 1
0.0376 0.6031 1
0.0164 0.4231 1
0.0065 0.9374 0.5
0.151 0.9985 1
0.1149 0.2629 1
0.0109 1 0.5
0.0376 1 1
0.1149 0.2629 1
0.1383 0.9825 1
0.0065 1 0.5
0.0306 0.3559 1
0.2251 0.9988 1
0.158 0.2763 1
0.0284 1 0.5
0.0054 0.6424 0.5
0.1267 0.9775 1
0.0436 0.3911 1
0.0759 0.6781 0.5
0.0784 1 0.5
0.0598 0.991 0.5
0.0281 0.337 1
0.0348 0.2648 0.8115
0.0599 0.2847 1
0.0065 1 1
0.1789 0.9992 1
0.1149 0.2629 1
0.0114 1 0.5
0.0801 0.9306 1
0.188 0.6306 1
0.0715 1 1
0.0739 0.3937 1
0.0159 1 0.5
0.0657 0.4521 0.5
0.0318 0.3357 1
0.1174 0.9858 1
0.0212 0.2716 1
0.0058 0.526 0.5
0.3277 0.7595 1
0.023 0.2747 0.5
0.1789 0.9992 1
0.0436 0.5515 1
0.0151 0.9901 0.5
0.062 0.9905 1
0.0123 1 1
0.0033 0.9498 0.5
0.0238 0.638 1
0.1379 0.9983 1
0.1053 0.9933 1
0.1376 0.9843 1
0.2498 0.7454 1
0.0065 0.4875 0.5
0.0598 0.4538 0.5
0.0318 0.2685 1
0.1254 0.9932 1
0.0271 1 0.5
0.0318 0.3357 1
0.0527 0.9975 0.5
0.0759 0.4419 1
0.0359 0.3158 1
0.0619636 0.540873 1
0.0659 0.9926 1
0.0243 0.8179 1
0.1011 0.2741 1
0.3274 0.9992 1
0.011 0.951 1
0.097 0.9987 1
0.0564 0.4503 0.9632
0.0065 0.4269 0.5
0.0317 0.9926 1
0.2498 0.7454 1
0.0852 0.4925 1
0.1123 0.937 1
0.023 0.7535 1
0.2687 0.393 1
0.0516 0.4833 0.5
0.1783 0.9986 1
0.0248 0.4087 0.5
0.0759 0.847 1
0.0359 0.3821 1
0.0065 1 1
0.1383 0.9825 1
0.2251 0.9988 1
0.1783 0.9986 1
0.1149 0.2629 1
0.0095 0.3149 1
0.0033 0.9498 0.5
0.0065 0.6856 1
0.0113 1 0.5
0.0177 0.7839 1
0.0456 0.538 1
0.0502 1 0.5
0.2251 0.9988 1
0.0291 1 0.5
0.0793 0.4588 1
0.0547 0.6277 1
0.1726 0.9986 1
0.1782 0.9755 0.5
0.0269 0.7927 0.5
0.0128 0.2809 0.5
0.013 0.9782 1
0.115 0.9904 1
0.2918 0.9991 1
0.0627 0.4588 1
0.0521 0.3921 1
0.0674 0.532 1
0.1153 0.998 1
0.0414 0.4003 1
0.1747 0.8768 1
0.1565 1 0.5
0.015 0.2573 1
0.2437 0.9989 1
0.158 0.2763 1
0.1924 0.9979 1
0.1261 0.9886 1
0.0098 0.9833 0.5
0.0758 0.3169 1
0.1141 0.9988 0.5
0.188 0.6306 1
0.0515 0.652 1
0.1396 0.4404 1
0.0629 0.9754 1
0.0468 1 1
0.0065 0.2973 1
0.1294 0.3959 0.4889
0.0758 0.3169 1
0.0056 0.2869 0.5
0.1149 0.2629 1
0.0971 0.9994 1
0.0598 0.7825 0.5
0.0098 0.9833 0.5
0.0328 0.6521 1
0.0156 0.8346 1
0.0342 1 1
0.0098 0.9833 0.5
0.1789 0.9992 1
0.0797 0.7108 1
0.1596 0.2743 1
0.0063 1 0.5
0.0116 0.3934 1
0.1596 0.2743 1
0.0811 0.3272 1
0.0891 1 1
0.0267 0.4251 1
0.0094 0.3124 1
0.2498 0.7454 1
0.0505 0.2885 1
0.0177 0.8736 1
0.0483 0.6754 1
0.0584 0.4463 1
0.036 0.5026 1
0.0252 0.3415 1
0.013 0.9782 1
0.0238 0.2682 1
0.0891 0.5102 1
0.0329 1 1
0.0065 1 0.5
0.1596 0.2743 1
0.2873 0.9995 1
0.0058 1 0.5
0.0065 1 0.5
0.1049 0.9865 1
0.1284 0.9881 1
0.0284 0.7595 1
0.0033 0.3417 0.5
0.1783 0.9986 1
0.079 0.2903 1
0.1396 0.4404 1
0.0132 0.3389 0.5
0.0338 0.2589 1
0.0527 1 1
0.0104045 0.973646 1
0.013 0.9782 1
0.2257 0.9953 1
0.2498 0.7454 1
0.0704 0.8746 1
0.0797 0.7108 1
0.0436 1 0.5
0.1294 0.3959 0.4889
0.0801 0.9767 1
0.0739 0.3937 1
0.0326 0.2502 0.9415
0.0472 0.3259 1
0.0318 0.3357 1
0.1782 0.992 1
0.0052 0.8728 1
0.1531 0.9862 1
0.0291 0.6558 1
0.0065 0.3128 1
0.0318 1 0.5
0.0255 0.2552 1
0.0065 1 0.5
0.1293 0.7469 1
0.0079 0.9833 0.5
0.0247 0.3383 1
0.0875 0.9856 1
0.0065 0.9434 0.5
0.0621 0.4064 0.5
0.0807 0.3068 1
0.1531 0.9803 1
0.0653 0.3174 1
0.0098 0.9835 1
0.023 0.7535 1
0.0527 0.9975 0.5
0.0109 1 0.5
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0.0098 0.9833 0.5
0.0105 0.332 1
0.1293 0.7469 1
0.0377 0.9817 1
0.0443 0.6535 1
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0.0098 0.9833 0.5
0.0065 0.3042 1
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0.1162 0.7951 1
0.1596 0.2743 1
0.0723 0.7467 0.5
0.018 1 1
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0.0326 0.2502 0.9415
0.0218 1 1
0.0065 1 1
0.0249506 0.400044 0.400044
0.0098 0.9835 1
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0.0098 0.9833 0.5
0.1293 0.7469 1
0.0754 0.5927 1
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0.0739 0.3937 1
0.1026 0.9879 1
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0.1842 0.8986 1
0.0115 0.3295 1
0.0165 0.3145 1
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0.0554 0.7946 1
0.1811 0.9825 1
0.1053 0.9933 1
0.0065 0.3371 0.2437
0.0284 0.9966 1
0.0065 0.3788 0.5
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0.027 1 1
0.1413 0.4921 1
0.0398 0.5968 1
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0.2423 0.9989 1
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0.0756 0.8342 0.5
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0.1149 0.2629 1
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0.0098 0.9833 0.5
0.05 0.4221 1
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0.0287 0.2731 1
0.0375 0.7437 1
0.1527 0.9919 1
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0.0107 0.6719 1
0.1026 0.9879 1
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0.1149 0.2629 1
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0.0159 0.5374 0.7498
0.0379 1 0.5
0.2119 0.9996 1
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0.0033 0.9498 0.5
0.091 0.3354 1
0.00654705 0.980922 0.5
0.0141923 0.314834 1
0.0088 0.9835 1
0.0905 0.6263 1
0.0315 0.3755 1
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0.111 0.7339 1
0.0033 0.9498 0.5
0.0221 0.4219 1
0.0655 0.3245 1
0.1294 0.2898 0.4889
0.023 0.7535 1
0.1379 0.9983 1
0.0248 0.7716 1
0.0065 1 0.5
0.0065 1 1
0.2342 0.9988 1
0.1162 0.7951 1
0.242 0.9967 1
0.0859 0.8757 1
0.0295 0.8902 1
0.0825 0.988 1
0.0852 0.4925 1
0.0658 1 1
0.1932 0.9992 1
0.2369 0.9988 1
0.0286 1 1
0.013 0.417 1
0.0109 0.3928 1
0.013 0.5583 1
0.1174 0.9858 1
0.2066 0.9987 1
0.0063 1 0.5
0.0156 0.9901 0.5
0.0125 1 0.5
0.0494 0.3011 1
0.0825 0.988 1
0.0033 0.9498 0.5
0.0098 0.9833 0.5
0.1221 1 1
0.0739 0.3937 1
0.136 0.8497 1
0.0098 0.9833 0.5
0.0436 0.3911 1
0.0807 0.3103 0.7757
0.0674 0.532 1
0.1117 0.9978 1
0.0558 0.9958 1
0.1294 0.2898 0.4889
0.00639609 0.980922 0.5
0.1053 0.9933 1
0.018 1 1
0.1149 0.2629 1
0.1596 0.2743 1
0.2536 0.9989 1
0.0758 0.3169 1
0.0315 0.3755 1
0.0528 0.8124 1
0.1294 0.3959 0.4889
0.0575 0.4975 1
0.1768 0.484 1
0.0033 0.9498 0.5
0.0065 0.2633 0.2633
0.0252 0.3415 1
0.0065 0.7385 0.5
0.0627 0.4588 1
0.0174 0.8736 1
0.0123 1 1
0.1782 0.992 1
0.037 0.4779 1
0.0065 0.9434 0.5
0.1596 0.2743 1
0.0523 0.9137 1
0.0394 0.4718 1
0.0098 0.9833 0.5
0.1021 0.9975 1
0.1565 1 0.5
0.0242 0.3374 1
0.0842 0.3697 1
0.0297 1 0.5
0.0065 1 1
0.0114 0.3629 1
0.0272 0.2858 1
0.2087 0.9987 1
0.074 0.5926 1
0.0665 0.4327 1
0.1281 0.9958 1
0.1596 0.2743 1
0.0053 0.743 1
0.0717763 0.974913 1
0.0186 0.9929 0.5
0.0095 0.3149 1
0.013 0.3106 1
0.1768 0.484 1
0.0445 1 1
0.0157 0.4849 1
0.2866 0.9991 1
0.0877 0.9917 1
0.0774 1 0.5
0.136 0.8497 1
0.2095 0.9989 1
0.0265 0.3113 1
0.022 1 1
0.0128 0.3682 1
0.0796 0.2685 0.5
0.2911 0.9991 1
0.0233 0.3739 1
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0.0811 0.3272 1
0.0401 0.9856 0.5
0.2419 0.9989 1
0.4784 0.2825 1
0.0348 0.2648 0.8115
0.0172 0.2526 0.5
0.0387 1 0.5
0.0647 0.9965 1
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0.3274 0.9992 1
0.0513 0.9945 1
0.0065 0.8692 0.5
0.0273 0.9959 0.5
0.158 0.2763 1
0.1293 0.7469 1
0.0209 1 1
0.0281 0.3369 1
0.1638 0.9991 0.5
0.1123 0.937 1
0.0065 0.4269 0.5
0.0242 1 1
0.0279 0.3335 1
0.1373 0.9834 1
0.0805 0.997 1
0.0935 1 0.5
0.1768 0.484 1
0.0554 1 0.5
0.0098 0.9833 0.5
0.0767 0.7272 1
0.0185 0.2958 1
0.0054 0.6791 0.5
0.0111 1 0.5
0.0466 0.4123 1
0.0703 0.8717 1
0.0797 0.7108 1
0.0098 0.9833 0.5
0.0098 0.9833 0.5
0.0098 0.5118 1
0.1293 0.7469 1
0.023 0.7535 1
0.158 0.2763 1
0.0098 0.9833 0.5
0.0057 0.3324 1
0.0248 0.6411 1
0.0807 0.3068 1
0.0065 1 0.5
0.0633 0.7116 1
0.0633 0.2919 1
0.2032 0.9988 1
0.2918 0.9991 1
0.0063 0.518 0.5
0.0754 0.5927 1
0.0891 1 1
0.0518 1 1
0.0229 0.558 0.5
0.08 1 0.5
0.016 1 0.5
0.0597 1 1
0.0164 0.4264 0.4264
0.1053 0.9933 1
0.1068 0.2532 1
0.1501 0.9843 1
0.0649 1 1
0.3274 0.9992 1
0.0843 0.7979 0.5
0.2918 0.9991 1
0.0233 0.3739 1
0.0614 1 0.5
0.0098 0.8876 1
0.1752 0.9985 1
0.0065 0.7816 0.5
0.1379 0.9983 1
0.1012 0.9987 0.5
0.0292 0.2893 1
0.0815 0.6022 1
0.2911 0.9991 1
0.1214 0.7931 1
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0.1149 0.2629 1
0.0548 0.9007 1
0.0317 0.9929 1
0.0164 0.4103 1
0.0133 0.4743 1
0.0753 0.9938 1
0.4801 0.2762 1
0.0199 0.6401 0.5
0.0549 0.7879 1
0.1684 0.9848 1
0.0065 1 0.5
0.1663 0.9853 1
0.0238 0.4146 1
0.0556 1 0.5
0.0233 0.308 1
0.2107 0.9989 1
0.1817 0.9987 1
0.0863 1 1
0.0104 0.5797 1
0.1556 0.9923 1
0.0109 0.3928 1
0.0065 1 0.5
0.0505 0.2885 1
0.0688 1 1
0.013 0.9782 1
0.0366 0.5173 1
0.2026 0.9988 1
0.0401 0.4867 1
0.0481 0.5914 1
0.0237 0.3448 1
0.0105 0.2804 0.5
0.0159 0.4776 1
0.0758 0.3169 1
0.1629 0.9984 1
0.1596 0.2743 1
0.2163 0.9988 1
0.3274 0.9992 1
0.049 0.5895 0.9993
0.026 0.337 1
0.0739 0.3937 1
0.0292 0.4235 1
0.0281 0.3337 1
0.0203 0.9931 1
0.0065 0.314 0.7689
0.0458 1 1
0.2251 0.9988 1
0.0227 0.6783 1
0.0433 0.9947 1
0.1598 0.9997 1
0.1076 0.9978 1
0.1487 0.9984 1
0.0344 0.9779 1
0.0033 0.9498 0.5
0.1596 0.2743 1
0.1666 0.9992 1
0.0577 1 1
0.1706 0.9985 1
0.0065 1 1
0.0033 0.9498 0.5
0.0265 0.3075 1
0.1789 0.9992 1
0.0879 0.9804 1
0.0242 1 1
0.1748 0.9853 1
0.132 0.9863 1
0.0098 0.9833 0.5
0.0152163 0.992242 1
0.0457 0.4604 1
0.4784 0.2825 1
0.013 1 0.5
0.0295 1 1
0.0098 0.9833 0.5
0.1149 0.2629 1
0.1096 1 0.5
0.0674 0.532 1
0.0869 0.5321 1
0.0057 0.3431 0.6015
0.0491 0.9952 1
0.192 0.3151 1
0.0105 0.3566 1
0.0118 0.3128 1
0.1294 0.2898 0.4889
0.0272 0.3201 1
0.1891 0.9987 1
0.0791 1 1
0.0114 1 1
0.0098 0.9833 0.5
0.0116 0.2878 0.5
0.0452 1 0.5
0.0065 1 1
0.1259 0.9994 1
0.1638 0.9991 0.5
0.192 0.3151 1
0.0913 0.2536 1
0.12 0.9994 1
0.1294 0.3958 0.4889
0.0729 0.9966 1
0.091 0.3354 1
0.07 0.278 1
0.0348 0.2648 0.8115
0.0065 0.7464 1
0.0743 1 0.5
0.2304 0.9988 1
0.1173 0.9987 0.5
0.188 0.6306 1
0.0065 1 1
0.0165 0.5226 1
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0.1554 0.9892 1
0.196 0.9987 1
0.0549 0.7879 1
0.0052 0.296 1
0.0065 1 0.5
0.0789 1 0.5
0.1346 0.9989 0.5
0.0107 0.4631 0.5
0.0285 0.3336 1
0.008 0.267 1
0.0332 0.4036 1
0.0891 0.5102 1
0.047 0.3292 1
0.049 0.5895 0.9993
0.0807 0.3103 0.7757
0.1219 0.4949 1
0.0265 0.3113 1
0.013 0.9782 1
0.013 0.9782 1
0.0772 0.9901 1
0.0112 1 1
0.0512 1 0.5
0.0177 0.2758 1
0.1084 1 0.5
0.0033 0.9498 0.5
0.0793 1 0.5
0.0065 1 0.5
0.1336 0.7746 1
0.0181 0.3733 0.5
0.0598 0.4538 0.5
0.1362 0.9969 1
0.2342 0.9988 1
0.0254 0.297 1
0.158 0.2763 1
0.0736 0.9958 1
0.0284 1 1
0.0326 0.2502 0.9415
0.0104045 0.973646 1
0.013 0.9782 1
0.1149 0.2629 1
0.0065 0.4297 0.5
0.013 0.3106 1
0.1789 0.9992 1
0.0739 0.3937 1
0.0754 0.5927 1
0.0131 0.6071 1
0.4662 0.6021 1
0.0635 0.9978 0.5
0.0098 0.9833 0.5
0.0489 0.4653 1
0.1596 0.2743 1
0.1759 0.9835 1
0.0146 0.384 0.5
0.0316 1 0.5
0.0065 1 0.5
0.0318 1 1
0.158 0.2763 1
0.0065 1 0.5
0.0324 0.2783 1
0.1293 0.7469 1
0.013 0.2977 1
0.0098 0.9833 0.5
0.0098 0.9833 0.5
0.1346 0.9989 0.5
0.0286 1 0.5
0.027 1 1
0.0582 0.3868 1
0.0815 0.6022 1
0.0065 0.6446 1
0.1294 0.2898 0.4889
0.1608 0.9992 1
0.0453 1 1
0.0171 1 0.5
0.0408 0.984 1
0.1219 0.4949 1
0.0337 1 1
0.0291 1 0.5
0.0287 1 1
0.0226 0.4452 1
0.0151 0.9902 1
0.0395 0.5549 1
0.0098 0.9833 0.5
0.1596 0.2743 1
0.1294 0.2898 0.4889
0.1293 0.7469 1
0.136 0.8497 1
0.0404 1 0.5
0.0215 1 0.5
0.0065 0.5282 1
0.013 0.9755 1
0.0383 1 1
0.0327 0.3492 1
0.0053 1 0.5
0.1096 1 0.5
0.1294 0.3958 0.4893
0.0597 1 1
0.0213 0.2689 1
0.1053 0.9933 1
0.0513 0.9945 1
0.2391 0.3312 1
0.1453 0.9827 1
0.0538 0.7377 1
0.0065 1 0.5
0.0335 0.7615 1
0.0304 0.5404 1
0.068 0.2566 1
0.0614 1 1
0.158 0.2763 1
0.1981 0.9987 1
0.1294 0.2898 0.4889
0.2479 0.9989 1
0.0714 0.9964 1
0.1057 0.9994 1
0.0946 0.9784 1
0.0443 0.6535 1
0.0188 1 1
0.0065 1 1
0.0065 1 0.5
0.13 0.4196 1
0.203 0.9082 1
0.0065 1 0.5
0.0115 0.4796 0
0.0052 0.296 1
0.0201 0.3375 0.5741
0.0843 1 1
0.0239 0.3354 1
0.0233 0.308 1
0.048 1 1
0.0146 0.3832 1
0.0318 0.3357 1
0.0594 1 1
0.1955 0.9988 1
0.4784 0.2825 1
0.0065 1 0.5
0.0558 0.6552 1
0.0172 0.3456 1
0.0755 0.8435 1
0.0598 0.4538 0.5
0.0638 0.9793 1
0.0152163 0.992242 1
0.0282 1 0.5
0.0331 1 0.5
0.1027 0.9919 1
0.0686 0.9967 1
0.0098 0.9833 0.5
0.1383 0.9825 1
0.0797 0.7108 1
0.0098 0.9833 0.5
0.1781 0.9986 1
0.1294 0.2898 0.4889
0.1227 0.9785 1
0.1331 0.9917 1
0.1294 0.3959 0.4889
0.059 0.7353 1
0.1626 0.9984 1
0.0755 0.6993 0.5
0.1845 0.7146 1
0.0725 0.742 0.5
0.0807 0.3103 0.7757
0.1294 0.2898 0.4889
0.1567 0.9815 1
0.1596 0.2743 1
0.0409 0.3972 1
0.1294 0.2898 0.4889
0.1053 0.9933 1
0.0702 0.9778 1
0.0234 0.3477 1
0.1527 0.9919 1
0.158 0.2763 1
0.015 0.2573 1
0.1294 0.2898 0.4889
0.1596 0.2743 1
0.2433 0.9989 1
0.0725 0.742 0.5
0.0551 0.3673 0.5
0.0841 0.9785 1
0.0115 1 1
0.1293 0.7469 1
0.0598 1 1
0.0434 0.4017 1
0.0811 0.3272 1
0.0065 1 0.5
0.1596 0.2743 1
0.0159 1 0.5
0.0242 1 1
0.1887 0.5121 1
0.0535 0.5505 1
0.0426 0.5332 1
0.0456 1 1
0.0251 0.337 1
0.1294 0.2899 0.4889
0.196 0.9987 1
0.0098 0.9833 0.5
0.0225 0.2584 1
0.2173 0.9988 1
0.0273 1 1
0.0338 0.2589 1
0.1293 0.7469 1
0.0835 1 0.5
0.1293 0.7469 1
0.1565 1 0.5
0.0271 1 0.5
0.0167 1 0.5
0.0359 0.3158 1
0.0306 0.3559 1
0.1396 0.4404 1
0.0575 1 0.5
0.0376 0.6031 1
0.0835 1 0.5
0.0271 1 0.5
0.1671 0.9986 1
0.0233 0.308 1
0.0065 1 1
0.0051 1 0.5
0.1151 0.3118 1
0.1608 0.9992 1
0.4044 0.7009 1
0.0739 0.3937 1
0.1293 0.7469 1
0.0267 0.9307 1
0.1839 0.9985 1
0.0969 1 1
0.1784 0.9991 0.5
0.0105 1 0.5
0.0584 0.4463 1
0.0781 0.275 1
0.1596 0.2743 1
0.0306 0.3022 1
0.0497 0.9986 1
0.0243 0.3388 1
0.0739 0.3937 1
0.0993 0.9869 1
0.1299 0.5192 1
0.1768 0.484 1
0.0052 1 1
0.1546 0.2578 1
0.018 0.4862 1
0.0098 0.9833 0.5
0.0065 0.3239 1
0.0373 0.3692 1
0.3277 0.7595 1
0.1419 0.9971 1
0.0852 0.4925 1
0.0065 0.3128 1
0.0327 0.3141 1
0.1385 0.9983 1
0.0328 0.6521 1
0.079 0.2903 1
0.158 0.2763 1
0.1813 0.9986 1
0.0597 1 1
0.0251 0.3628 1
0.136 0.8497 1
0.122 0.9981 1
0.2044 0.9988 1
0.0118 0.3128 1
0.1317 0.9839 1
0.097 0.9987 1
0.0378 1 0.5
0.056 1 1
0.0061 1 0.5
0.0065 1 0.5
0.0478 0.3629 0.5
0.0915 1 0.5
0.1951 0.9987 1
0.1149 0.2629 1
0.0576 0.7891 1
0.0376 0.6031 1
0.1501 0.9843 1
0.1167 0.9891 1
0.0065 1 0.5
0.1294 0.2898 0.4889
0.0171 0.9843 0.5
0.0105 1 0.5
0.158 0.2763 1
0.061 0.4295 0.5
0.0342 0.268 1
0.016 0.2987 1
0.0098 0.9833 0.5
0.034 0.4848 1
0.0167 1 0.5
0.0523 0.6498 1
0.0248 1 1
0.0457 1 1
0.1293 0.7469 1
0.1355 0.3539 1
0.0404 1 0.5
0.0245 0.3378 1
0.1642 0.9834 1
0.3368 0.9975 1
0.0391 1 1
0.2618 0.9962 1
0.1149 0.2629 1
0.0058 0.526 0.5
0.013 1 0.5
0.1878 0.9986 1
0.0098 0.9833 0.5
0.0877 0.9917 1
0.0739 0.3937 1
0.0092 0.984 1
0.4662 0.6021 1
0.0318 0.3357 1
0.0754 0.5927 1
0.013 1 0.5
0.1268 0.9988 0.5
0.0329 0.2838 1
0.1596 0.2743 1
0.0443 0.6535 1
0.0511 0.3058 1
0.0901 0.9947 1
0.085 0.3175 1
0.0062 0.2701 1
0.0267 0.3149 1
0.437 0.9972 1
0.0277 1 1
0.0463 0.8652 0.5
0.0852 0.4925 1
0.0645 0.9787 0.5
0.0597 0.6017 1
0.0268 1 1
0.0065 1 0.5
0.0324 0.2783 1
0.0451 1 0.5
0.0622 1 0.5
0.4313 0.2717 1
0.0487 1 0.5
0.1266 1 1
0.4784 0.7419 1
0.0273 1 1
0.1294 0.2898 0.4889
0.0758 0.3169 1
0.0073 0.258 0.3576
0.1265 0.9879 1
0.0304 0.6337 1
0.1404 0.9982 1
0.0431 1 0.5
0.0428 0.978 1
0.033 1 1
0.0098 0.9833 0.5
0.1085 0.9922 1
0.4662 0.6683 1
0.0116 0.3934 1
0.1053 0.9933 1
0.0326 0.2502 0.9415
0.4784 0.2825 1
0.1657 0.9813 1
0.0383 0.9783 1
0.0825 0.988 1
0.1294 0.3959 0.4889
0.0396 0.3976 1
0.1214 0.7931 1
0.1331 0.9917 1
0.035 0.413 1
0.0052 0.6588 0.5
0.0302 0.9968 1
0.0074 0.369 0.5
0.0641 0.4439 1
0.1633 0.9834 1
0.0437 1 1

Assayability

Assay information

  • Assay for FK-Binding Protein Peptidyl-Prolyl Isomerase Activity (5.2.1.8 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Plasmodium falciparum ( 1 )

Reagent availability

  • Pber002870AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pber002870; Recombinant protein: full-length; Source: P berghei; 70 kDa peptidylprolyl isomerase, putative homolog ; Identifier: PB301525.00.0
  • Reagent:
  • Target Type Source Notes
    PF3D7_1247400 purified protein BRENDA A protein with this EC number or name or sequence has been purified from Plasmodium falciparum ( 2 )

Bibliographic References

13 literature references were collected for this gene.

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Gene identifier PF3D7_1247400 (Plasmodium falciparum), peptidyl-prolyl cis-trans isomerase FKBP35
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