pI: 9.6914 |
Length (AA): 159 |
MW (Da): 18685 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
52 | 157 | 1naq (A) | 7 | 112 | 36.00 | 0 | 1 | 1.23 | -1.66 |
53 | 157 | 1osc (A) | 8 | 112 | 45.00 | 0 | 1 | 1.32 | -1.77 |
50 | 157 | 4e98 (A) | 8 | 115 | 37.00 | 0 | 1 | 1.24545 | -1.05 |
51 | 157 | 2zom (A) | 5 | 111 | 46.00 | 0 | 1 | 1.32746 | -1.04 |
54 | 157 | 2nuh (A) | 3 | 106 | 36.00 | 0 | 1 | 1.20169 | -1.22 |
54 | 156 | 3gsd (A) | 16 | 118 | 37.00 | 0 | 0.99 | 1.2273 | -1.2 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 48 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, Oocyst, Sporozoite. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 0 hs, merozoite, Ring, Female Gametocyte, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs. | Otto TD |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_128186)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G33740 | copper binding protein CutA |
Brugia malayi | Bm1_33805 | CutA1 divalent ion tolerance protein |
Caenorhabditis elegans | CELE_F35G12.7 | Protein F35G12.7 |
Cryptosporidium hominis | Chro.60280 | divalent cation tolerance protein |
Cryptosporidium parvum | cgd6_2410 | possible CutA1 divalent ion tolerance protein |
Drosophila melanogaster | Dmel_CG11590 | CG11590 gene product from transcript CG11590-RA |
Escherichia coli | b4137 | divalent-cation tolerance protein, copper sensitivity |
Homo sapiens | ENSG00000112514 | cutA divalent cation tolerance homolog (E. coli) |
Loa Loa (eye worm) | LOAG_05021 | CutA1 divalent ion tolerance protein |
Mus musculus | ENSMUSG00000024194 | cutA divalent cation tolerance homolog (E. coli) |
Mus musculus | ENSMUSG00000026870 | cutA divalent cation tolerance homolog-like |
Neospora caninum | NCLIV_047800 | hypothetical protein |
Oryza sativa | 4348499 | Os10g0378300 |
Oryza sativa | 9267187 | Os03g0186950 |
Onchocerca volvulus | OVOC2794 | Protein CutA homolog |
Plasmodium berghei | PBANKA_1462400 | cutA, putative |
Plasmodium falciparum | PF3D7_1249500 | cutA, putative |
Plasmodium knowlesi | PKNH_1469200 | cutA homologue, putative |
Plasmodium vivax | PVX_101362 | cutA, putative |
Schistosoma japonicum | Sjp_0213110 | ko:K03926 periplasmic divalent cation tolerance protein, putative |
Schistosoma mansoni | Smp_048870 | divalent cation tolerance cuta-related |
Schmidtea mediterranea | mk4.000315.10 | Protein CutA |
Schmidtea mediterranea | mk4.000488.02 | |
Trypanosoma brucei gambiense | Tbg972.4.4410 | divalent cation tolerance protein, putative |
Trypanosoma brucei | Tb927.4.4320 | divalent cation tolerance protein, putative |
Trypanosoma congolense | TcIL3000_8_8220 | divalent cation tolerance protein, putative |
Trypanosoma congolense | TcIL3000_8_8090 | divalent cation tolerance protein, putative |
Trypanosoma congolense | TcIL3000_4_3660 | divalent cation tolerance protein, putative |
Trypanosoma cruzi | TcCLB.504717.10 | divalent cation tolerance protein, putative |
Trypanosoma cruzi | TcCLB.505009.20 | divalent cation tolerance protein, putative |
Trypanosoma cruzi | TcCLB.504411.20 | divalent cation tolerance protein, putative |
Trypanosoma cruzi | TcCLB.506489.59 | divalent cation tolerance protein, putative |
Toxoplasma gondii | TGME49_224910 | divalent cation tolerance protein, CutA1 family protein |
Wolbachia endosymbiont of Brugia malayi | Wbm0766 | hypothetical protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.4320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.4320 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.4320 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.4320 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4137 | Escherichia coli | non-essential | goodall |
TGME49_224910 | Toxoplasma gondii | Essentiality uncertain | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2