pI: 8.4049 |
Length (AA): 336 |
MW (Da): 37424 |
Paralog Number:
11
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
28 | 333 | 5fpw (A) | 9 | 314 | 87.00 | 0 | 1 | 1.94641 | -1.13 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127800)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G02300 | putative cathepsin B-like cysteine protease |
Arabidopsis thaliana | AT1G02305 | putative cathepsin B-like cysteine protease |
Arabidopsis thaliana | AT4G01610 | putative cathepsin B-like cysteine protease |
Brugia malayi | Bm1_33735 | cathepsin B-like cysteine proteinase |
Caenorhabditis elegans | CELE_F57F5.1 | Protein F57F5.1 |
Caenorhabditis elegans | CELE_F44C4.3 | Protein CPR-4 |
Caenorhabditis elegans | CELE_W07B8.5 | Protein CPR-5 |
Caenorhabditis elegans | CELE_C25B8.3 | Protein CPR-6, isoform A |
Dictyostelium discoideum | DDB_G0288563 | hypothetical protein |
Dictyostelium discoideum | DDB_G0283921 | cathepsin B precursor |
Drosophila melanogaster | Dmel_CG10992 | Cathepsin B1 |
Echinococcus granulosus | EgrG_000790300 | cathepsin b |
Echinococcus granulosus | EgrG_000790200 | cathepsin b |
Echinococcus multilocularis | EmuJ_000790300 | cathepsin b |
Echinococcus multilocularis | EmuJ_000790200 | cathepsin b |
Giardia lamblia | GL50803_14019 | Cathepsin B precursor |
Giardia lamblia | GL50803_16160 | Cathepsin B precursor |
Giardia lamblia | GL50803_16779 | Cathepsin B precursor |
Homo sapiens | ENSG00000164733 | cathepsin B |
Leishmania braziliensis | LbrM.29.0850 | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like |
Leishmania donovani | LdBPK_290860.1 | cysteine peptidase C (CPC) |
Leishmania infantum | LinJ.29.0860 | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like |
Leishmania major | LmjF.29.0820 | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like |
Leishmania mexicana | LmxM.08_29.0820 | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like |
Loa Loa (eye worm) | LOAG_08355 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11371 | cathepsin B |
Mus musculus | ENSMUSG00000021939 | cathepsin B |
Neospora caninum | NCLIV_069550 | Cathepsin B-like protease (Precursor), related |
Oryza sativa | 9267789 | Os05g0310500 |
Schistosoma japonicum | Sjp_0214180 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma japonicum | Sjp_0077110 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma japonicum | Sjp_0089450 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma japonicum | Sjp_0089420 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma japonicum | Sjp_0131900 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma japonicum | Sjp_0007940 | ko:K01363 cathepsin B [EC3.4.22.1], putative |
Schistosoma japonicum | Sjp_0068040 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma japonicum | Sjp_0303350 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma japonicum | Sjp_0218410 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma japonicum | Sjp_0214190 | Cathepsin B-like cysteine proteinase precursor, putative |
Schistosoma mansoni | Smp_103610 | cathepsin B-like peptidase (C01 family) |
Schistosoma mansoni | Smp_158420 | cathepsin B-like peptidase (C01 family) |
Schistosoma mansoni | Smp_179950 | cathepsin B-like peptidase (C01 family) |
Schistosoma mansoni | Smp_067060 | cathepsin B-like peptidase (C01 family) |
Schistosoma mansoni | Smp_141610 | SmCB2 peptidase (C01 family) |
Schmidtea mediterranea | mk4.002490.00 | Cathepsin B |
Schmidtea mediterranea | mk4.000308.13 | Cathepsin B |
Trypanosoma brucei gambiense | Tbg972.6.220 | cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative |
Trypanosoma brucei | Tb927.6.560 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_11180 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_28450 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_6_60 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_03600 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_41960 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_15150 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_48140 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_56080 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_32450 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_48090 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_35720 | cysteine peptidase C (CPC) |
Trypanosoma congolense | TcIL3000_0_45430 | cysteine peptidase C (CPC) |
Trypanosoma cruzi | TcCLB.510535.100 | cysteine peptidase C (CPC), putative |
Trypanosoma cruzi | TcCLB.511827.100 | cysteine peptidase C (CPC), putative |
Toxoplasma gondii | TGME49_249670 | cathepsin B |
Trichomonas vaginalis | TVAG_482410 | Clan CA, family C1, cathepsin B-like cysteine peptidase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.560 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.560 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.6.560 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F57F5.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F57F5.1 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_249670 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | cathepsin B | Compounds | References |
Bos taurus | Cathepsin B | Compounds | References |
Trypanosoma brucei | cysteine peptidase C (CPC) | Compounds | References |
Rattus norvegicus | Cathepsin B | Compounds | References |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | Compounds | References |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | Compounds | References |
Trypanosoma brucei gambiense | cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative | Compounds | References |
Homo sapiens | cathepsin B | Compounds | References |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | Compounds | References |
Capra hircus | Cathepsin B | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Canis familiaris | Cathepsin K | 330 aa | 26.8% | 276 aa | Compounds | References |
Oryctolagus cuniculus | Cathepsin K | 329 aa | 26.4% | 276 aa | Compounds | References |
Bos taurus | Cathepsin L | 334 aa | 26.8% | 280 aa | Compounds | References |
Rattus norvegicus | Cathepsin L | 334 aa | 28.3% | 279 aa | Compounds | References |
Rattus norvegicus | Cathepsin K | 329 aa | 27.5% | 273 aa | Compounds | References |