Detailed view for TcIL3000_0_36490

Basic information

TDR Targets ID: 559932
Trypanosoma congolense, RNA helicase, putative
Source Database / ID: 

pI: 9.0966 | Length (AA): 917 | MW (Da): 102567 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00075   RNase H
PF00552   Integrase DNA binding domain
PF00665   Integrase core domain
PF02022   Integrase Zinc binding domain
PF06817   Reverse transcriptase thumb domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0008270   zinc ion binding  
GO:0004523   ribonuclease H activity  
GO:0003964   RNA-directed DNA polymerase activity  
GO:0003676   nucleic acid binding  
GO:0015074   DNA integration  
GO:0006278   RNA-dependent DNA replication  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
233 588 1mu2 (A) 205 543 26.00 0.0000013 1 0.484022 0.98
611 880 5ejk (A) 1 268 29.00 0 1 0.615238 0.03
612 650 5cz2 (G) 2 40 41.00 0.021 1 0.72433 -1.78
661 821 5cz2 (A) 51 207 50.00 0 1 0.769373 -0.9
828 877 5d7u (A) 215 264 44.00 0 0.99 0.711026 -1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_139608)

Species Accession Gene Product
Mus musculus 101055928   predicted gene, 29744
Plasmodium yoelii PY07014   integrase-related
Schistosoma mansoni Smp_194210   hypothetical protein
Trypanosoma brucei Tb11.v5.0494   RNA helicase, putative
Trypanosoma congolense TcIL3000_0_36490   RNA helicase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 integrase Compounds References
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 reverse transcriptase Compounds References
Rous sarcoma virus (strain Prague C) (RSV-PrC) Rous sarcoma virus integrase Compounds References
Human immunodeficiency virus 1 Reverse transcriptase Compounds References
Human immunodeficiency virus 2 Human immunodeficiency virus type 2 integrase Compounds References
Human immunodeficiency virus type 1 group M subtype B (isolateBRU/LAI) (HIV-1) Gag-Pol polyprotein Compounds References
Mouse mammary tumor virus (strain GR) (MMTV) Envelope glycoprotein gp70 Compounds References
Human immunodeficiency virus type 1 group M subtype A (isolate U455)(HIV-1) Gag-Pol polyprotein Compounds References
Human immunodeficiency virus 1 Integrase Compounds References
Human immunodeficiency virus 2 Human immunodeficiency virus type 2 pol protein Compounds References
Human immunodeficiency virus type 1 group M subtype B (isolateARV2/SF2) (HIV-1) Gag-Pol polyprotein Compounds References
Human immunodeficiency virus 2 Reverse transcriptase Compounds References
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)(HIV-1) Gag-Pol polyprotein Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier TcIL3000_0_36490 (Trypanosoma congolense), RNA helicase, putative
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