Detailed view for Rv3841

Basic information

TDR Targets ID: 5711
Mycobacterium tuberculosis, Bacterioferritin BfrB

Source Database / ID:  Tuberculist 

pI: 4.4692 | Length (AA): 181 | MW (Da): 20442 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00210   Ferritin-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0046914   transition metal ion binding  
GO:0016491   oxidoreductase activity  
GO:0008199   ferric iron binding  
GO:0006879   cellular iron ion homeostasis  
GO:0006826   iron ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 181 3uno (A) 8 181 99.99 0 1 2.22133 -1.67

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 3OJ5:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3QD8:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3UNO:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date


Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase, Dormant phase. hasan murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.


Ortholog group members (OG5_127547)

Species Accession Gene Product
Arabidopsis thaliana AT3G11050   ferritin 2
Arabidopsis thaliana AT5G01600   ferretin 1
Arabidopsis thaliana AT3G56090   ferritin 3
Arabidopsis thaliana AT2G40300   ferritin 4
Caenorhabditis elegans CELE_C54F6.14   Protein FTN-1
Caenorhabditis elegans CELE_D1037.3   Protein FTN-2
Drosophila melanogaster Dmel_CG4349   Ferritin 3 heavy chain homologue
Escherichia coli b1905   ferritin iron storage protein (cytoplasmic)
Echinococcus granulosus EgrG_000382200   ferritin
Echinococcus granulosus EgrG_000315600   expressed protein
Echinococcus multilocularis EmuJ_000315600   expressed protein
Echinococcus multilocularis EmuJ_000382200   ferritin
Homo sapiens ENSG00000167996   ferritin, heavy polypeptide 1
Mus musculus ENSMUSG00000024661   ferritin heavy chain 1
Mycobacterium tuberculosis Rv3841   Bacterioferritin BfrB
Mycobacterium ulcerans MUL_5014   bacterioferritin BfrB
Oryza sativa 9269178   Os11g0106700
Oryza sativa 4351264   Os12g0106000
Schistosoma japonicum Sjp_0024490   Ferritin-2 heavy chain, putative
Schistosoma japonicum Sjp_0024480   ko:K00522 ferroxidase [EC1.16.3.1], putative
Schistosoma japonicum Sjp_0305720   Ferritin, putative
Schistosoma japonicum Sjp_0201280   ko:K00522 ferroxidase [EC1.16.3.1], putative
Schistosoma mansoni Smp_047660   ferritin
Schistosoma mansoni Smp_087760   ferritin light chain
Schistosoma mansoni Smp_047680   ferritin
Schistosoma mansoni Smp_047640   ferritin
Schistosoma mansoni Smp_063530.1   apoferritin-2
Schistosoma mansoni Smp_063530.2   apoferritin-2
Schistosoma mansoni Smp_047670   ferritin
Schistosoma mansoni Smp_047650   ferritin light chain
Schmidtea mediterranea mk4.000323.19  
Schmidtea mediterranea mk4.000246.15  
Schmidtea mediterranea mk4.004514.05  
Schmidtea mediterranea mk4.000323.11  
Schmidtea mediterranea mk4.003701.00  
Schmidtea mediterranea mk4.033615.00   Apoferritin-2
Schmidtea mediterranea mk4.020937.03  
Schmidtea mediterranea mk4.000291.06   Apoferritin-2
Schmidtea mediterranea mk4.017054.00  
Schmidtea mediterranea mk4.005420.05  
Schmidtea mediterranea mk4.001444.01  
Schmidtea mediterranea mk4.014419.00   Apoferritin-2
Schmidtea mediterranea mk4.020745.00  
Schmidtea mediterranea mk4.001444.03  
Trichomonas vaginalis TVAG_208690   ferritin, putative


Rv3841 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu3908 this record Mycobacterium tuberculosis non-essential nmpdr
b1905 Escherichia coli non-essential goodall
CELE_C54F6.14 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0018 0.3986 0
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.0008 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.001 1 0.5
0.0008 1 0.5
0.0019 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.0026 0.2873 0
0.0009 0.6584 0.5
0.0008 0.5 0.5
0.001 0.5 0.5
0.0026 0.2873 0
0.001 0.5 0.5
0.001 0.5 0.5
0.001 0.5 0.5
0.0009 0.5 0.5


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Rv3841 (Mycobacterium tuberculosis), Bacterioferritin BfrB
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