pI: 5.6322 |
Length (AA): 689 |
MW (Da): 75587 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 14
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
12 | 569 | 2xq2 (A) | 12 | 503 | 33.00 | 0 | 1 | 0.974969 | 0.39 |
15 | 524 | 5nv9 (A) | 13 | 458 | 26.00 | 0 | 0.84 | 0.885903 | 0.23 |
602 | 668 | 3lbx (B) | 1999 | 2065 | 18.00 | 0 | 0.02 | 0.296342 | -0.33 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127197)
Species | Accession | Gene Product |
---|---|---|
Drosophila melanogaster | Dmel_CG42235 | CG42235 gene product from transcript CG42235-RE |
Escherichia coli | b3679 | putative transporter |
Echinococcus granulosus | EgrG_000951000 | sodium:glucose cotransporter 2 |
Echinococcus granulosus | EgrG_000714050 | solute carrier family 5 |
Echinococcus granulosus | EgrG_001173900 | sodium:myo inositol cotransporter |
Echinococcus granulosus | EgrG_000714000 | sodium:glucose cotransporter |
Echinococcus multilocularis | EmuJ_000951000 | sodium:glucose cotransporter 2 |
Echinococcus multilocularis | EmuJ_000714000 | solute carrier family 5 |
Echinococcus multilocularis | EmuJ_001173900 | sodium:myo inositol cotransporter |
Homo sapiens | ENSG00000140675 | solute carrier family 5 (sodium/glucose cotransporter), member 2 |
Homo sapiens | ENSG00000100191 | solute carrier family 5 (glucose activated ion channel), member 4 |
Homo sapiens | ENSG00000198743 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 |
Homo sapiens | ENSG00000100170 | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
Homo sapiens | ENSG00000117834 | solute carrier family 5 (sodium/sugar cotransporter), member 9 |
Homo sapiens | ENSG00000154025 | solute carrier family 5 (sodium/sugar cotransporter), member 10 |
Homo sapiens | ENSG00000158865 | solute carrier family 5 (sodium/inositol cotransporter), member 11 |
Mus musculus | ENSMUSG00000011034 | solute carrier family 5 (sodium/glucose cotransporter), member 1 |
Mus musculus | ENSMUSG00000030781 | solute carrier family 5 (sodium/glucose cotransporter), member 2 |
Mus musculus | 64454 | solute carrier family 5 (neutral amino acid transporters, system A), member 4b |
Mus musculus | ENSMUSG00000033255 | predicted gene 5134 |
Mus musculus | ENSMUSG00000030769 | solute carrier family 5 (sodium/glucose cotransporter), member 11 |
Mus musculus | ENSMUSG00000042371 | solute carrier family 5 (sodium/glucose cotransporter), member 10 |
Mus musculus | ENSMUSG00000020229 | solute carrier family 5, member 4a |
Mus musculus | ENSMUSG00000028544 | solute carrier family 5 (sodium/glucose cotransporter), member 9 |
Mus musculus | ENSMUSG00000089774 | solute carrier family 5 (inositol transporters), member 3 |
Schistosoma japonicum | Sjp_0020360 | Sodium/myo-inositol cotransporter, putative |
Schistosoma japonicum | Sjp_0070630 | ko:K03307 solute:Na+ symporter, SSS family, putative |
Schistosoma japonicum | Sjp_0310080 | expressed protein |
Schistosoma mansoni | Smp_134080 | inositol transporter |
Schistosoma mansoni | Smp_134070 | inositol transporter |
Schmidtea mediterranea | mk4.006081.00 | |
Schmidtea mediterranea | mk4.001839.03 | |
Schmidtea mediterranea | mk4.037618.00 | |
Schmidtea mediterranea | mk4.001839.02 | |
Schmidtea mediterranea | mk4.015373.00 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b3679 | Escherichia coli | non-essential | goodall |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Compounds | References |
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 1 | Compounds | References |
Homo sapiens | solute carrier family 5 (sodium/inositol cotransporter), member 11 | Compounds | References |
Homo sapiens | solute carrier family 5 (sodium/glucose cotransporter), member 2 | Compounds | References |
Mus musculus | solute carrier family 5 (sodium/glucose cotransporter), member 1 | Compounds | References |
Rattus norvegicus | Sodium/glucose cotransporter 1 | Compounds | References |
Rattus norvegicus | Sodium/glucose cotransporter 2 | Compounds | References |
Homo sapiens | solute carrier family 5 (glucose activated ion channel), member 4 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Sodium/iodide cotransporter | 618 aa | 22.8% | 540 aa | Compounds | References |