pI: 7.8481 |
Length (AA): 444 |
MW (Da): 50046 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 430 | 3rch (A) | 2 | 480 | 34.00 | 0 | 1 | 1.25856 | 0.36 |
8 | 428 | 3k40 (A) | 5 | 475 | 37.00 | 0 | 1 | 1.3183 | 0.05 |
109 | 169 | 2pyq (A) | 49 | 86 | 45.00 | 0 | 0.76 | -0.0793126 | 1.12 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129065)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G28680 | tyrosine decarboxylase |
Arabidopsis thaliana | AT2G20340 | tyrosine decarboxylase 1 |
Brugia malayi | Bm1_42020 | Aromatic-L-amino-acid decarboxylase |
Caenorhabditis elegans | CELE_K01C8.3 | Protein TDC-1, isoform A |
Drosophila melanogaster | Dmel_CG30446 | Tyrosine decarboxylase 2 |
Drosophila melanogaster | Dmel_CG10697 | Dopa decarboxylase |
Drosophila melanogaster | Dmel_CG30445 | Tyrosine decarboxylase 1 |
Echinococcus granulosus | EgrG_002064300 | hypothetical protein |
Echinococcus granulosus | EgrG_001173700 | aromatic amino acid decarboxylase |
Echinococcus multilocularis | EmuJ_001173700 | aromatic amino acid decarboxylase |
Homo sapiens | ENSG00000132437 | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
Leishmania braziliensis | LbrM.30.2460 | tyrosine/dopa decarboxylase, putative,dopa decarboxylase, putative |
Leishmania donovani | LdBPK_302490.1 | tyrosine/dopa decarboxylase, putative |
Loa Loa (eye worm) | LOAG_07708 | TDC-1 protein |
Mus musculus | ENSMUSG00000020182 | dopa decarboxylase |
Oryza sativa | 4343080 | Os07g0437500 |
Schistosoma japonicum | Sjp_0128920 | Aromatic-L-amino-acid decarboxylase, putative |
Schistosoma japonicum | Sjp_0050680 | Aromatic-L-amino-acid decarboxylase, putative |
Schistosoma japonicum | Sjp_0103650 | Aromatic-L-amino-acid decarboxylase, putative |
Schistosoma mansoni | Smp_171580 | phenylalanine decarboxylase |
Schmidtea mediterranea | mk4.004156.03 | Aromatic-L-amino-acid decarboxylase |
Schmidtea mediterranea | mk4.000417.03 | Histidine decarboxylase |
Schmidtea mediterranea | mk4.001687.03 | |
Schmidtea mediterranea | mk4.001687.04 | Aromatic-L-amino-acid decarboxylase |
Schmidtea mediterranea | mk4.004509.00 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | dopa decarboxylase | Compounds | References |