Detailed view for EgrG_000939400

Basic information

TDR Targets ID: 577765
Echinococcus granulosus, beta LACTamase domain containing family member

Source Database / ID:  GeneDB

pI: 7.7186 | Length (AA): 489 | MW (Da): 53221 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00144   Beta-lactamase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
38 470 2qmi (A) 2 370 21.00 0 1 0.899881 0.86
40 436 1ci9 (A) 20 391 20.00 0 1 0.980261 0.12
42 442 1yqs (A) 11 347 26.00 0 1 0.952441 -0.02
56 150 3wrz (A) 27 116 40.00 0.0000017 0.78 0.458674 1.01

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_134259)

Species Accession Gene Product
Brugia malayi Bm1_36605   beta-lactamase
Caenorhabditis elegans CELE_Y45F10D.11   Protein LACT-9, isoform B
Dictyostelium discoideum DDB_G0294597   beta-lactamase family protein
Echinococcus granulosus EgrG_000939400   beta LACTamase domain containing family member
Echinococcus multilocularis EmuJ_000939400   beta LACTamase domain containing family member
Homo sapiens ENSG00000103642   lactamase, beta
Loa Loa (eye worm) LOAG_08351   beta-lactamase
Mus musculus ENSMUSG00000032370   lactamase, beta
Schistosoma japonicum Sjp_0006610   expressed protein
Schistosoma japonicum Sjp_0006630   Serine beta-lactamase-like protein LACTB, mitochondrial precursor, putative
Schistosoma mansoni Smp_037900   family S12 unassigned peptidase (S12 family)
Schmidtea mediterranea mk4.009436.00   Serine beta-lactamase-like protein LACTB, mitochondrial
Schmidtea mediterranea mk4.026497.00   Serine beta-lactamase-like protein LACTB, mitochondrial
Schmidtea mediterranea mk4.009436.02   Family S12 unassigned peptidase
Schmidtea mediterranea mk4.004718.00   Serine beta-lactamase-like protein LACTB, mitochondrial
Schmidtea mediterranea mk4.006716.00   Family S12 unassigned peptidase
Trichomonas vaginalis TVAG_343410   penicillin-binding protein, putative

Essentiality

EgrG_000939400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y45F10D.11 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y45F10D.11 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EgrG_000939400 (Echinococcus granulosus), beta LACTamase domain containing family member
Title for this comment
Comment