Detailed view for EgrG_001115900

Basic information

TDR Targets ID: 578745
Echinococcus granulosus, fetal alzheimer antigen falz

Source Database / ID:  GeneDB

pI: 6.9796 | Length (AA): 2902 | MW (Da): 317561 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00628   PHD-finger
PF02791   DDT domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0048188   COMPASS complex  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
62 169 5cwk (A) 46 153 15.00 0 0.05 0.316316 -1.63
467 519 2yql (A) 4 56 51.00 0.0000000000066 1 0.573963 0.37
471 522 2ke1 (A) 295 348 52.00 0.00000000018 0.95 0.592619 -0.07
474 516 4qf3 (A) 1933 1978 37.00 0.0066 0.82 0.381517 0.08
1466 1673 4nu2 (A) 64 272 13.00 0 0 0.153775 -0.05
1473 1711 4ut1 (A) 309 537 28.00 0.42 0.13 0.065057 1.13
2641 2695 1wep (A) 9 61 47.00 0 0.97 0.504052 0.05
2642 2699 2fui (A) 6 61 54.00 0.0000000000066 1 0.610686 0.02
2699 2756 3kqi (A) 0 56 47.00 0 1 0.601086 -0.68
2704 2893 2ri7 (A) 8 174 29.00 0 1 0.220572 0.46
2704 2889 2ri7 (A) 8 170 37.00 0 1 0.261794 0.05
2800 2891 5uiy (A) 1437 1533 25.00 0 1 0.433802 -1.45
2800 2896 1e6i (A) 335 436 26.00 0 1 0.440525 -1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_168626)

Species Accession Gene Product
Caenorhabditis elegans CELE_F26H11.2   Protein NURF-1, isoform J
Echinococcus granulosus EgrG_001115900   fetal alzheimer antigen falz
Schistosoma japonicum Sjp_0317170   Conserved hypothetical protein
Schistosoma mansoni Smp_038990   bromodomain containing protein
Schmidtea mediterranea mk4.001276.04  

Essentiality

EgrG_001115900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F26H11.2 Caenorhabditis elegans slow growth wormbase
CELE_F26H11.2 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0148 0.2795 0.3496
0.0025 0.2583 0.317
0.0024 0.2583 0.3145
0.0026 0.2583 0.3145
0.0026 0.2647 0.3145
0.0029 0.252 0.3145
0.0025 0.2523 0.2395
0.0029 0.252 0.3145
0.0029 0.2647 0.3145
0.0023 0.2583 0.3145
0.0026 0.252 0.3145
0.0029 0.2583 0.3145
0.0029 0.2583 0.3145
0.0028 0.2583 0.3169
0.0029 0.2583 0.3145
0.0029 0.2583 0.3145
0.0029 0.252 0.3145
0.0029 0.2583 0.3145
0.0029 0.252 0.3145
0.0024 0.2583 0.3126
0.0533 0.2516 0.2503

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001115900 (Echinococcus granulosus), fetal alzheimer antigen falz
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