Detailed view for EgrG_000575900

Basic information

TDR Targets ID: 579684
Echinococcus granulosus, basement membrane specific heparan sulfate
Source Database / ID:  GeneDB

pI: 4.7525 | Length (AA): 7809 | MW (Da): 859887 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00052   Laminin B (Domain IV)
PF00057   Low-density lipoprotein receptor domain class A
PF13927   Immunoglobulin domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
341 671 2v5r (A) 17 351 23.00 0.0082 0.74 0.040087 1.56
437 932 3b43 (A) 6 455 23.00 0.0028 1 0.0562165 1.47
712 754 2knx (A) 1 39 51.00 0.081 0.98 0.483206 -0.3
720 754 2m7p (A) 3 39 51.00 0 0.85 0.518882 -0.91
723 761 4u8u (M) 62 102 49.00 0.64 0.95 0.690694 -1.61
830 977 5uv6 (A) 113 249 33.00 0.18 0.45 0.00165249 1.12
1161 1263 2y38 (A) 294 433 35.00 0.0019 0.45 -0.0451101 0.93
1187 1383 4wnx (A) 293 460 33.00 0.0000034 0.98 -0.251073 1.44
1685 1792 3pxh (A) 137 226 36.00 0.55 0.99 0.22953 0.13
2630 2779 5w59 (B) 174 298 30.00 0.59 0.15 0.0529086 0.71
4626 4720 2edj (A) 8 99 14.00 0.78 0.04 0.00546545 -0.08
7613 7797 3b5h (A) 32 203 16.00 0 0.81 0.0240906 0.5
7702 7799 5fm5 (O) 250 339 20.00 0.76 0.62 0.11785 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_150147)

Species Accession Gene Product
Brugia malayi Bm1_08985   basement membrane proteoglycan precursor
Echinococcus granulosus EgrG_000575900   basement membrane specific heparan sulfate
Echinococcus granulosus EgrG_000701800   basement membrane specific heparan sulfate
Echinococcus multilocularis EmuJ_000575900   basement membrane specific heparan sulfate
Echinococcus multilocularis EmuJ_000701800   basement membrane specific heparan sulfate
Loa Loa (eye worm) LOAG_12565   hypothetical protein
Schistosoma japonicum Sjp_0102000   IPR007110,Immunoglobulin-like,domain-containing
Schistosoma japonicum Sjp_0050390   IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like;IPR008972,Cupredoxin,domain-containing
Schistosoma japonicum Sjp_0103630   Basement membrane-specific heparan sulfate proteoglycan core protein precursor, putative
Schistosoma japonicum Sjp_0073100   Basement membrane-specific heparan sulfate proteoglycan core protein precursor, putative
Schistosoma japonicum Sjp_0102010   expressed protein
Schistosoma japonicum Sjp_0094390   IPR002049,EGF-like, laminin;IPR003599,Immunoglobulin subtype;IPR013032,EGF-like region;IPR007110,Immunoglobulin-like,domain-cont
Schistosoma japonicum Sjp_0114820   IPR013151,Immunoglobulin;IPR003599,Immunoglobulin subtype;IPR000437,Prokaryotic membrane lipoprotein lipid attachment site;IPR00
Schistosoma japonicum Sjp_0103640   IPR002172,Low density lipoprotein-receptor, class A;IPR003599,Immunoglobulin subtype;IPR007110,Immunoglobulin-like,domain-contai
Schistosoma japonicum Sjp_0121380   expressed protein
Schistosoma japonicum Sjp_0094380   IPR013032,EGF-like region;IPR000034,Laminin B,domain-containing
Schistosoma mansoni Smp_146950   hypothetical protein
Schistosoma mansoni Smp_190810   hypothetical protein
Schistosoma mansoni Smp_193720   hypothetical protein
Schistosoma mansoni Smp_020550   low-density lipoprotein receptor (ldl)
Schmidtea mediterranea mk4.001574.02  
Schmidtea mediterranea mk4.032087.00  
Schmidtea mediterranea mk4.030592.00  
Schmidtea mediterranea mk4.004112.03  
Schmidtea mediterranea mk4.000386.22  
Schmidtea mediterranea mk4.007668.00  
Schmidtea mediterranea mk4.002076.05   Low-density lipoprotein receptor
Schmidtea mediterranea mk4.004731.01  
Schmidtea mediterranea mk4.004185.06  
Schmidtea mediterranea mk4.001097.01  
Schmidtea mediterranea mk4.008721.01  
Schmidtea mediterranea mk4.035166.00  
Schmidtea mediterranea mk4.007668.01  
Schmidtea mediterranea mk4.000951.02  
Schmidtea mediterranea mk4.000668.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0006 0.5 0.5
0.0005 0.5 0.5
0.0089 0.4346 0.4346
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0114 0.5665 0.5665
0.0012 0.5 0.5
0.0006 0.5 0.5
0.0063 0.5623 0.508
0.0006 0.5 0.5
0.0006 1 1
0.0006 1 1
0.0005 1 1
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0025 0.277 0.277
0.0012 0.5 0.5
0.0006 1 1
0.0006 0.5 0.5
0.0006 0.5 0.5
0.0012 0.5 0.5
0.0006 0.5 0.5
0.0163 0.3454 0.3454
0.0012 0.5 0.5
0.0005 1 1
0.0103 0.9438 0.9438

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000575900 (Echinococcus granulosus), basement membrane specific heparan sulfate
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