Detailed view for EgrG_000444400
Basic information
Echinococcus granulosus, serine:threonine protein kinase SMG1
Source Database / ID: GeneDB
pI: 6.9007 |
Length (AA): 3837 |
MW (Da): 426299 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0016301 kinase activity
GO:0005515 protein binding
GO:0004674 protein serine/threonine kinase activity
GO:0016310 phosphorylation
Metabolic Pathways
Structural information
Modbase 3D models:
There are 11 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 10 | 98 | 3d9h (A) | 102 | 191 | 38.00 | 0.014 | 1 | 0.520295 | -0.76 |
| 39 | 105 | 2xen (A) | 13 | 78 | 35.00 | 0 | 1 | 0.527262 | -1.15 |
| 41 | 86 | 5mbl (B) | 329 | 375 | 48.00 | 0.00059 | 1 | 0.566089 | -0.03 |
| 41 | 98 | 2bkk (B) | 80 | 137 | 43.00 | 0.00042 | 1 | 0.565216 | -0.59 |
| 249 | 358 | 3c5r (A) | 0 | 530 | 12.00 | 0.0000000029 | 0.28 | 0.216268 | -0.5 |
| 262 | 362 | 2rfm (A) | 71 | 171 | 13.00 | 0.00000000071 | 0.38 | 0.225923 | -0.42 |
| 1606 | 2609 | 5wby (B) | 1547 | 2433 | 21.00 | 0 | 1 | 0.241263 | 0.9 |
| 2147 | 2251 | 4dri (B) | 2019 | 2110 | 18.00 | 0.0003 | 0.63 | 0.187965 | -0.68 |
| 2407 | 2527 | 1he8 (A) | 866 | 965 | 37.00 | 0.8 | 0.15 | -0.0533649 | 1.81 |
| 2871 | 3688 | 5me3 (B) | 463 | 1304 | 11.00 | 0 | 0.99 | 0.214987 | 0.68 |
| 3302 | 3698 | 4k6j (B) | 0 | 1108 | 15.00 | 0 | 0.69 | 0.271266 | -0.31 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
Orthologs
Ortholog group members (OG5_131142)
| Species | Accession | Gene Product |
|---|---|---|
| Brugia malayi | Bm1_48115 | Phosphatidylinositol 3- and 4-kinase family protein |
| Brugia malayi | Bm1_48110 | hypothetical protein |
| Caenorhabditis elegans | CELE_C48B6.6 | Protein SMG-1, isoform B |
| Dictyostelium discoideum | DDB_G0275845 | PIKK family protein kinase |
| Drosophila melanogaster | Dmel_CG32743 | no-on-and-no-off transient C |
| Echinococcus granulosus | EgrG_000444400 | serine:threonine protein kinase SMG1 |
| Echinococcus multilocularis | EmuJ_000444400 | serine:threonine protein kinase SMG1 |
| Homo sapiens | 101060386 | serine/threonine-protein kinase SMG1-like |
| Homo sapiens | ENSG00000157106 | SMG1 phosphatidylinositol 3-kinase-related kinase |
| Homo sapiens | 101060596 | serine/threonine-protein kinase SMG1-like |
| Loa Loa (eye worm) | LOAG_15020 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_08420 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_07367 | hypothetical protein |
| Loa Loa (eye worm) | LOAG_10772 | hypothetical protein |
| Mus musculus | ENSMUSG00000030655 | SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans) |
| Oryza sativa | 4334045 | Os03g0738100 |
| Schistosoma japonicum | Sjp_0066930 | ko:K08873 PI-3-kinase-related kinase SMG-1, putative |
| Schistosoma mansoni | Smp_118260 | hypothetical protein |
| Schistosoma mansoni | Smp_142710 | fkbp-rapamycin associated protein |
| Schmidtea mediterranea | mk4.008791.03 | Serine/threonine-protein kinase smg-1 |
| Schmidtea mediterranea | mk4.008142.00 | SMG-1 |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
| Species | Known druggable target | Linked compounds | Reference |
|---|---|---|---|
| Homo sapiens | SMG1 phosphatidylinositol 3-kinase-related kinase | Compounds | References |
By sequence similarity to non orthologous druggable targets
Obtained from network model
Ranking Plot
Putative Drugs List
Assayability
Assay information
Reagent availability
Bibliographic References