Detailed view for EgrG_001067700

Basic information

TDR Targets ID: 580454
Echinococcus granulosus, membrane associated guanylate kinase ww and pdz
Source Database / ID:  GeneDB

pI: 8.7513 | Length (AA): 1284 | MW (Da): 137407 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00595   PDZ domain (Also known as DHR or GLGF)
PF00625   Guanylate kinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

Rap1 signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 17 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
31 121 5vwi (A) 11 92 25.00 0.047 0.83 0.162272 0.42
46 120 2jil (A) 162 226 24.00 0.4 0.14 0.0508112 0.42
1156 1263 2kr0 (A) 270 380 16.00 0 0.01 0.167112 -0.12
36 118 2dkr (A) 8 76 20.00 0.11 0.27 0.0018659 0.67
36 118 5emb (A) 41 120 23.00 0.095 0.91 0.236866 0.16
41 135 3jxt (A) 409 489 20.00 0.85 0.35 0.112678 -0.06
277 327 2yse (A) 10 59 48.00 0.0000024 0.5 0.510601 0.17
281 310 1i5h (W) 461 490 43.00 0.62 0.9 0.56343 -0.43
339 461 1wif (A) 2 111 34.00 0.0000009 1 0.457472 -0.51
370 460 3soe (A) 598 680 33.00 0 1 0.540807 -1.71
814 890 2qg1 (A) 1735 1807 34.00 0.026 1 0.52886 -1
922 1142 3gsl (A) 60 245 30.00 0.00000000019 1 0.268603 0.58
968 1029 1v62 (A) 46 107 35.00 0.023 1 0.461595 0.15
1059 1142 2r4h (A) 3 85 53.00 0 1 0.730584 -0.66
1061 1220 2krg (A) 154 299 23.00 0 0.8 0.189226 1.17
1156 1206 3mp6 (A) 1201 1250 13.00 0 0.04 0.103101 -0.76
1160 1220 1oqy (A) 89 144 29.00 0.42 0.01 0.0848773 1.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129479)

Species Accession Gene Product
Brugia malayi Bm1_27395   PDZ domain containing protein
Caenorhabditis elegans CELE_K01A6.2   Protein MAGI-1, isoform A
Drosophila melanogaster Dmel_CG30388   CG30388 gene product from transcript CG30388-RA
Echinococcus granulosus EgrG_000388700   3'partial|membrane associated guanylate kinase ww and pdz
Echinococcus granulosus EgrG_001067700   membrane associated guanylate kinase ww and pdz
Echinococcus granulosus EgrG_002065200   membrane associated guanylate kinase, WW and PDZ
Echinococcus granulosus EgrG_000194900   membrane associated guanylate kinase ww and pdz
Echinococcus multilocularis EmuJ_000388700   membrane associated guanylate kinase ww and pdz
Echinococcus multilocularis EmuJ_000194900   membrane associated guanylate kinase, WW and PDZ
Echinococcus multilocularis EmuJ_001067700  
Homo sapiens ENSG00000187391   membrane associated guanylate kinase, WW and PDZ domain containing 2
Homo sapiens ENSG00000151276   membrane associated guanylate kinase, WW and PDZ domain containing 1
Homo sapiens ENSG00000081026   membrane associated guanylate kinase, WW and PDZ domain containing 3
Loa Loa (eye worm) LOAG_05231   hypothetical protein
Loa Loa (eye worm) LOAG_06884   hypothetical protein
Mus musculus ENSMUSG00000045095   membrane associated guanylate kinase, WW and PDZ domain containing 1
Mus musculus ENSMUSG00000052539   membrane associated guanylate kinase, WW and PDZ domain containing 3
Mus musculus ENSMUSG00000040003   membrane associated guanylate kinase, WW and PDZ domain containing 2
Schistosoma japonicum Sjp_0043500   ko:K06112 membrane-associated guanylate kinase-related, putative
Schistosoma mansoni Smp_141790   membrane associated guanylate kinase inverted related
Schistosoma mansoni Smp_132600   membrane associated guanylate kinase inverted related
Schmidtea mediterranea mk4.039583.00  
Schmidtea mediterranea mk4.000668.09  
Schmidtea mediterranea mk4.022411.00  
Schmidtea mediterranea mk4.031292.00  
Schmidtea mediterranea mk4.020773.00  
Schmidtea mediterranea mk4.020773.01   Membrane associated guanylate kinase inverted related
Schmidtea mediterranea mk4.000668.06  
Schmidtea mediterranea mk4.027987.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens membrane associated guanylate kinase, WW and PDZ domain containing 3 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0192 0.2798 1
0.0127 0.4186 1
0.0044 0.2612 0.2895
0.0218 0.5248 0.5248
0.0042 0.4319 0.4319
0.0373 0.3621 0.5002
0.0194 0.2828 1
0.0218 0.5248 0.5248
0.018 0.261 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001067700 (Echinococcus granulosus), membrane associated guanylate kinase ww and pdz
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