Detailed view for Rv2276

Basic information

TDR Targets ID: 5812
Mycobacterium tuberculosis, Cytochrome P450 121 Cyp121

Source Database / ID:  Tuberculist 

pI: 6.6149 | Length (AA): 396 | MW (Da): 43256 | Paralog Number: 716

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0009055   electron carrier activity  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 396 1n40 (A) 2 396 99.99 0 1 2.25657 -1.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 1N40:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1N4G:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2IJ5:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2IJ7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3CXV:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3CXX:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3CXY:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3CXZ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3CY0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3CY1:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3G5F:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3G5H:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4G1X:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4G2G:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4G44:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4G45:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4G46:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4G47:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4G48:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4ICT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4IPS:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4IPW:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4IQ7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4IQ9:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KTF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KTJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KTK:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KTL:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5EDT:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5IBD:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5IBE:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5IBF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5IBG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5IBH:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5IBI:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5IBJ:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5O4K:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5O4L:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5OP9:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5OPA:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5WP2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. hasan
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium smegmatis 6333   8390   12544   51955   68461   513383   542204   553767  
Annotator: crowther@u.washington.edu. Comment: 2007-12-20. References: 12368427

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6


Known modulators for this target

Compound Source Reference
ChEMBL23 References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0127 0.5337 0.5
0.0011 0.5 0.5
0.0049 0.293 0.5
0.00109509 1 0.5
0.0016 1 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0054 1 0.5
0.0078 1 0.5
0.026 0.251 1
0.0197 0.6846 0.5
0.0082 0.5 0.5
0.0053 1 0.5
0.0004 0.5 0.5
0.0033 0.5 0.5
0.007 1 1
0.0184 0.3352 0.9605
0.0057 0.2766 1
0.0004 0.5 0.5
0.0114 1 0.5
0.0011 1 0.5
0.0015 0.5 0.5
0.0106 0.2751 1
0.0016 0.5 0.5
0.0051 0.5 0.5
0.0004 0.5 0.5
0.036 0.2841 0.7643
0.004 1 0.5
0.007 0.5 0.5
0.0018 0.5004 0.5
0.0011 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0166 0.2888 0
0.0044 0.4237 0.5
0.0046 0.5 0.5
0.0004 0.5 0.5
0.0026 0.5 0.5
0.0133 0.256 0.5
0.0008 0.5 0.5
0.0056 0.3577 1
0.0011 0.5 0.5
0.0008 0.3317 0
0.0014 0.5 0.5
0.0003 0.5 0.5
0.0036 0.5 0.5
0.0167 0.2978 0.5
0.0032 0.5 0.5
0.0004 0.5 0.5
0.0069 1 0.5
0.0111 0.3549 0.362
0.0004 0.5 0.5
0.0091 0.2951 1
0.0353 0.4928 0.5
0.0035 0.4422 0.5
0.0004 0.5 0.5
0.0038 1 0.5
0.0004 0.5 0.5
0.0055 0.2887 0.5
0.0052 0.2829 0.5
0.008 0.2556 1
0.0007 0.5 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.015 0.2827 0.5891
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0073 1 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0007 0.5 0.5
0.0054 0.5 0.5
0.0052 0.3769 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0173 0.3457 0
0.0065 1 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0062 0.2905 1
0.00213675 0.269186 0.5
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0046 0.6591 1
0.0036 0.5 0.5
0.0073 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0011 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0104 0.5 0.5
0.0022 0.5 0.5
0.0021 0.5 0.5
0.0084 0.5 0.5
0.0082 0.5 0.5
0.008 0.5 0.5
0.0012 0.5 0.5
0.0029 1 0.5
0.0004 0.5 0.5
0.0341 0.2689 0.5
0.0004 0.5 0.5
0.003 0.3271 0.5
0.0028 0.5 0.5
0.0004 0.5 0.5
0.0004 1 0.5
0.0008 0.5 0.5
0.00213675 0.269186 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0323 0.3673 1
0.0092 0.467 0.5
0.0057 0.2766 1
0.0018 0.2637 0.5
0.0162 0.2769 1
0.0036 1 0.5
0.0059 0.6064 0.5
0.0083 0.5 0.5
0.0388 0.2772 0.5
0.0033 0.2605 0.5
0.0011 0.5 0.5
0.0077 0.5 0.5
0.0042 0.3378 0.5
0.0027 1 0.5
0.033 0.3723 1
0.0018 0.5 0.5
0.0067 0.5 0.5
0.00213675 0.269186 0.5
0.0331 0.3985 1
0.0026 0.5 0.5
0.0284 0.2924 1
0.026 0.251 1
0.0331 0.3985 1
0.0079 0.2909 0.5653
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0102 0.3061 0.3937
0.0004 0.5 0.5
0.0119 0.4458 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.00451124 0.405669 0.5
0.0049 0.6682 0.5
0.0004 0.5 0.5
0.0028 0.2972 1
0.00777519 0.280873 1
0.0093 0.5 0.5
0.0011 0.5 0.5
0.0284 0.2924 1
0.0217 0.8044 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0353 0.4928 0.5
0.0316 0.2652 0.7504
0.0021 0.4036 0
0.0011 0.5 0.5
0.0048 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.015 0.2827 0.5891
0.0025 0.5 0.5
0.0004 0.5 0.5
0.0184 0.3508 0.5
0.0004 0.5 0.5
0.0072 1 0.5
0.0291 0.2657 0.5
0.0044 0.6112 0.5
0.0069 0.5 0.5
0.0145 0.7126 0.5
0.004 0.5565 0.5
0.0023 1 0.5
0.006 0.2795 0.5
0.0087 1 0.5
0.033 0.3723 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0019 0.271 0.5
0.0047 0.6689 0.5
0.0048 0.6634 0.5
0.0007 0.5 0.5
0.0074 1 0.5
0.0065 0.3393 0.3393
0.025 0.2789 0.5
0.0026 0.5 0.5
0.0004 0.5 0.5
0.0124 0.2696 0.8052
0.0004 0.5 0.5
0.0063 0.5 0.5
0.0103 0.6953 1
0.0012 0.5 0.5
0.007 1 1
0.0114 1 0.5
0.033 0.3723 1
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0037 0.2694 1
0.0028 0.5 0.5
0.0137 0.271 1
0.0073 0.5 0.5
0.0004 0.5 0.5
0.0316 0.2652 0.7504
0.0361 0.2704 0.5
0.0068 1 0.5
0.0046 0.6591 1
0.000396385 0.5 0.5
0.0044 0.2627 0
0.0032 1 0.5
0.007 0.5713 0.5
0.0008 0.5 0.5
0.0059 0.5 0.5
0.0323 0.2823 0.8288
0.0004 0.5 0.5
0.0094 0.2887 0.5
0.0146 0.6654 0.5
0.0004 0.5 0.5
0.0018 1 0.5
0.0027 1 1
0.0025 0.5 0.5
0.0023 0.9674 0.5
0.0103 0.4147 0.4168
0.0262 0.3083 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0324 0.2701 1
0.0008 1 0.5
0.005 1 0.5
0.0202 0.2702 0.5446
0.0326 0.2819 0.5
0.0099 0.7062 0.5
0.0004 0.5 0.5
0.015 0.3435 0.5
0.0007 1 0.5
0.0062 0.5 0.5
0.0286 1 1
0.0003 0.5 0.5
0.0121 1 1
0.0011 1 0.5
0.0103 1 0.5
0.0235 0.3192 0.6178
0.0092 1 0.5
0.0004 0.5 0.5
0.0059 0.5 0.5
0.0067 0.5 0.5
0.0066 0.5 0.5
0.0004 0.5 0.5
0.0058 0.5 0.5
0.00184047 0.269186 0.5
0.0157 0.3541 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0289 0.2916 1
0.0047 0.5 0.5
0.0087 1 0.5
0.0071 0.5 0.5
0.0007 0.5 0.5
0.0059 0.6064 0.5
0.0007 0.5 0.5
0.0063 0.2543 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0008 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0066 1 0.5
0.0047 0.6638 0.5
0.000376403 0.5 0.5
0.0173 0.3858 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0056 0.6399 0.5
0.0072 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0033 0.5 0.5
0.0007 1 0.5
0.0004 0.5 0.5
0.0368 0.2796 1
0.0018 0.5 0.5
0.0569 0.2624 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0071 0.3514 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0065 0.5 0.5
0.0004 0.5 0.5
0.0034 0.337 1
0.0075 0.3265 0
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0122 0.4249 1
0.0032 1 0.5
0.0004 0.5 0.5
0.0063 0.4653 0.5
0.0094 0.5 0.5
0.0004 0.5 0.5
0.002 0.5 0.5
0.0174 0.2937 0.5
0.0015 0.5 0.5
0.0076 1 1
0.0036 0.4353 0.5
0.0084 1 0.5
0.0133 0.2787 0.8245
0.0019 0.2756 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 1 0.5
0.0099 0.7122 0.5
0.0084 0.3462 0.6551
0.0004 0.5 0.5
0.0032 0.5 0.5
0.0004 0.5 0.5
0.0037 0.4283 0.5
0.0004 0.5 0.5
0.0176 0.3425 1
0.0071 0.2928 0.5
0.0063 0.3886 0.5
0.0004 0.5 0.5
0.0368 0.2796 1
0.0086 0.5 0.5
0.0268 0.2982 1
0.0011 0.5 0.5
0.000218985 0.5 0.5
0.00213675 0.269186 0.5
0.0443 0.3118 1
0.0075 0.2816 0.5
0.0004 0.5 0.5
0.0038 0.5102 0.5
0.0004 0.5 0.5
0.0108 0.2733 1
0.0284 0.2726 1
0.0004 0.5 0.5
0.0189 0.5524 0.5
0.0228 0.2829 0.5
0.0033 0.5 0.5
0.000218985 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0022 0.5 0.5
0.0018 0.2876 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0388 0.2772 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.008 0.2582 1
0.0004 0.5 0.5
0.0004 1 0.5
0.005 0.3622 0.5
0.004 1 0.5
0.0004 0.5 0.5
0.0081 0.5 0.5
0.0002 0.5 0.5
0.0118 0.3485 0.5
0.0075 1 0.5
0.0007 0.5 0.5
0.0185 0.2528 0.5
0.0065 1 0.5
0.0071 0.5 0.5
0.0004 0.5 0.5
0.0217 0.2742 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0081 0.5 0.5
0.0038 0.5 0.5
0.0047 0.6638 0.5
0.0033 0.3348 0.5
0.0042 0.5 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0051 0.5 0.5
0.0156 0.4244 1
0.0203 0.2689 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0267 0.27 0.5
0.004 1 0.5
0.005 0.2698 0.5
0.0027 0.5 0.5
0.0059 0.6064 0.5
0.0052 0.3825 0.5
0.004 1 1
0.0216 0.2583 0.5
0.0068 0.4312 1
0.0008 0.5 0.5
0.002 1 0.5
0.0008 0.3317 0
0.0004 0.5 0.5
0.01 0.5 0.5
0.0346 0.2559 0.6171
0.0023 1 1
0.00139338 1 0.5
0.0069 0.2847 0.4473
0.0029 0.36 0.5
0.0019 0.271 0.5
0.0004 0.5 0.5
0.0029 0.5 0.5
0.000376403 0.5 0.5
0.0004 0.5 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0146 0.6069 0.5
0.0004 0.5 0.5
0.0032 0.5 0.5
0.0164 0.3784 0.5
0.0004 0.5 0.5
0.0235 0.2812 1
0.0004 0.5 0.5
0.0093 0.3481 0.6382
0.0051 0.3758 0.5
0.0007 0.5 0.5
0.0083 1 0.5
0.0193 0.311 0
0.0004 0.5 0.5
0.0046 0.2608 0.5
0.034 0.2765 0.5
0.0119 0.4458 0.5
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0063 0.5 0.5
0.0023 0.5 0.5
0.0022 0.3789 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0023 0.5 0.5
0.0007 0.5 0.5
0.007 0.3303 0.4951
0.0071 0.9628 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0059 0.6064 0.5
0.0082 0.5 0.5
0.0336 0.2847 0.5
0.0018 0.3602 0.5
0.0004 0.5 0.5
0.004 1 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5004 0.5
0.003 0.3514 0.5
0.0246 0.2667 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0119 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0083 0.6735 0.5
0.0004 0.5 0.5
0.0166 0.5366 0.5
0.0048 0.6597 0.5
0.0004 0.5 0.5
0.005 0.5 0.5
0.00505219 0.5 0.5
0.0569 0.2624 1
0.0042 1 0.5
0.0004 0.5 0.5
0.008 1 0.5
0.0249 0.3082 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0016 1 0.5
0.0038 0.525 0.5
0.0078 0.3003 0.5792
0.0055 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.0022 0.3489 0.5
0.0046 0.5 0.5
0.0007 0.5 0.5
0.0051 0.4977 0.5
0.0068 0.5 0.5

Assayability

Assay information

  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis CYP121
  • ChEMBL
  • Binding affinity to Mycobacterium tuberculosis H37Rv wild type CYP121 by titration assay

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Rv2276 (Mycobacterium tuberculosis), Cytochrome P450 121 Cyp121
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