Detailed view for EgrG_000706900

Basic information

TDR Targets ID: 581403
Echinococcus granulosus, Ezrin radixin moesin ERM
Source Database / ID:  GeneDB

pI: 7.739 | Length (AA): 2181 | MW (Da): 240149 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00373   FERM central domain
PF08736   FERM adjacent (FA)
PF09379   FERM N-terminal domain
PF09380   FERM C-terminal PH-like domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005856   cytoskeleton  
GO:0008092   cytoskeletal protein binding  

Metabolic Pathways

Rap1 signaling pathway (KEGG)
Adherens junction (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
16 381 2i1k (A) 3 383 24.00 0 1 0.432013 -0.08
16 294 2he7 (A) 108 388 37.00 0 1 0.625023 -0.56
18 294 3qij (A) 210 488 39.00 0 1 0.611206 -0.64
664 859 4az1 (A) 87 266 12.00 0.0093 0.14 0.104467 -0.06
1977 2180 4tql (A) 10 216 14.00 0.0000046 0.41 0.284135 -0.65
2057 2171 5j0l (D) 4 122 13.00 0.98 0.02 0.260328 -1.21

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_162601)

Species Accession Gene Product
Brugia malayi Bm1_31895   FERM domain
Caenorhabditis elegans CELE_H05G16.1   Protein FRM-3
Echinococcus granulosus EgrG_000706900   Ezrin radixin moesin ERM
Echinococcus granulosus EgrG_000773400   Pleckstrin y
Echinococcus multilocularis EmuJ_000706900   Ezrin radixin moesin ERM
Echinococcus multilocularis EmuJ_000773400   Pleckstrin y
Loa Loa (eye worm) LOAG_13467   hypothetical protein
Loa Loa (eye worm) LOAG_09595   FERM domain-containing protein
Schistosoma japonicum Sjp_0089870   FERM, RhoGEF and pleckstrin domain-containing protein 2, putative
Schistosoma mansoni Smp_024070   hypothetical protein
Schmidtea mediterranea mk4.003637.02   Putative 4.1 G protein
Schmidtea mediterranea mk4.039593.00   Putative 4.1 G protein
Schmidtea mediterranea mk4.018473.03   Putative 4.1 G protein

Essentiality

EgrG_000706900 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_H05G16.1 Caenorhabditis elegans larval arrest wormbase
CELE_H05G16.1 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000706900 (Echinococcus granulosus), Ezrin radixin moesin ERM
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