pI: 8.837 |
Length (AA): 639 |
MW (Da): 73565 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
313 | 410 | 2hvk (C) | 25 | 124 | 22.00 | 0 | 0.03 | 0.278965 | 0.67 |
404 | 595 | 2ptm (A) | 471 | 662 | 54.00 | 0 | 1 | 1.02707 | -0.93 |
404 | 602 | 3u0z (A) | 390 | 587 | 49.00 | 0 | 1 | 0.974924 | -0.89 |
470 | 597 | 4muv (A) | 227 | 351 | 32.00 | 0 | 1 | 0.708913 | -1.23 |
505 | 601 | 2oz6 (A) | 31 | 135 | 26.00 | 0.095 | 0.97 | 0.4994 | -0.47 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128920)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G02850 | potassium channel SKOR |
Arabidopsis thaliana | AT5G37500 | potassium channel GORK |
Drosophila melanogaster | Dmel_CG8585 | I[[h]] channel |
Echinococcus granulosus | EgrG_001054100 | hyperpolarization activated cyclic |
Echinococcus granulosus | EgrG_001053800 | hyperpolarization activated cyclic |
Echinococcus granulosus | EgrG_000169800 | potassium:sodium hyperpolarization activated |
Echinococcus multilocularis | EmuJ_001054100 | hyperpolarization activated cyclic |
Echinococcus multilocularis | EmuJ_001053800 | hyperpolarization activated cyclic |
Echinococcus multilocularis | EmuJ_000169800 | potassium:sodium hyperpolarization activated |
Homo sapiens | ENSG00000138622 | hyperpolarization activated cyclic nucleotide-gated potassium channel 4 |
Homo sapiens | 348980 | hyperpolarization activated cyclic nucleotide-gated potassium channel 1 |
Homo sapiens | ENSG00000099822 | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 |
Homo sapiens | ENSG00000143630 | hyperpolarization activated cyclic nucleotide-gated potassium channel 3 |
Mus musculus | ENSMUSG00000020331 | hyperpolarization-activated, cyclic nucleotide-gated K+ 2 |
Mus musculus | ENSMUSG00000028051 | hyperpolarization-activated, cyclic nucleotide-gated K+ 3 |
Mus musculus | 15165 | hyperpolarization-activated, cyclic nucleotide-gated K+ 1 |
Mus musculus | ENSMUSG00000032338 | hyperpolarization-activated, cyclic nucleotide-gated K+ 4 |
Schistosoma japonicum | Sjp_0086710 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, putative |
Schistosoma japonicum | Sjp_0043050 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, putative |
Schistosoma japonicum | Sjp_0032950 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, putative |
Schistosoma japonicum | Sjp_0032970 | hypothetical protein |
Schistosoma japonicum | Sjp_0043070 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, putative |
Schistosoma japonicum | Sjp_0068230 | ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative |
Schistosoma japonicum | Sjp_0043080 | Conserved hypothetical protein |
Schistosoma japonicum | Sjp_0068240 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3, putative |
Schistosoma japonicum | Sjp_0032960 | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, putative |
Schistosoma japonicum | Sjp_0032980 | IPR013621,Ion transport N-terminal,domain-containing |
Schistosoma mansoni | Smp_174860 | hyperpolarization activated cyclic nucleotide-gated potassium channel |
Schistosoma mansoni | Smp_168880 | hyperpolarization activated cyclic nucleotide-gated potassium channel |
Schistosoma mansoni | Smp_153100 | hyperpolarization activated cyclic nucleotide-gated potassium channel |
Schmidtea mediterranea | mk4.002334.02 | |
Schmidtea mediterranea | mk4.021033.02 | Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative |
Schmidtea mediterranea | mk4.020548.00 | I+AFsAWw-h+AF0AXQ- channel |
Schmidtea mediterranea | mk4.020548.01 | Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative |
Schmidtea mediterranea | mk4.000906.05 | Putative potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel |
Schmidtea mediterranea | mk4.006769.01 | I+AFsAWw-h+AF0AXQ- channel |
Schmidtea mediterranea | mk4.024152.01 | Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative |
Schmidtea mediterranea | mk4.004890.00 | I+AFsAWw-h+AF0AXQ- channel |
Schmidtea mediterranea | mk4.001755.01 | Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative |
Schmidtea mediterranea | mk4.001755.00 | I+AFsAWw-h+AF0AXQ- channel |
Schmidtea mediterranea | mk4.000906.06 | |
Schmidtea mediterranea | mk4.018412.00 | Hyperpolarization activated cyclic nucleotide-gated potassium channel, putative |
Schmidtea mediterranea | mk4.014789.00 | |
Schmidtea mediterranea | mk4.022649.03 | |
Schmidtea mediterranea | mk4.006769.00 | I+AFsAWw-h+AF0AXQ- channel |
Schmidtea mediterranea | mk4.018865.00 | |
Schmidtea mediterranea | mk4.002334.01 | I+AFsAWw-h+AF0AXQ- channel |
Trichomonas vaginalis | TVAG_147120 | voltage and ligand gated potassium channel, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | hyperpolarization activated cyclic nucleotide-gated potassium channel 1 | Compounds | References |
Homo sapiens | hyperpolarization activated cyclic nucleotide-gated potassium channel 3 | Compounds | References |
Homo sapiens | hyperpolarization activated cyclic nucleotide-gated potassium channel 4 | Compounds | References |
Mus musculus | hyperpolarization-activated, cyclic nucleotide-gated K+ 1 | Compounds | References |
Mus musculus | hyperpolarization-activated, cyclic nucleotide-gated K+ 2 | Compounds | References |
Homo sapiens | hyperpolarization activated cyclic nucleotide-gated potassium channel 2 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Cavia porcellus | Potassium voltage-gated channel subfamily H member 2 | 162 aa | 29.9% | 184 aa | Compounds | References |