Detailed view for EgrG_000059400

Basic information

TDR Targets ID: 581798
Echinococcus granulosus, pikachurin
Source Database / ID:  GeneDB

pI: 8.5621 | Length (AA): 515 | MW (Da): 57531 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00054   Laminin G domain
PF02210   Laminin G domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
112 393 3qcw (A) 617 892 27.00 0.000000000013 1 0.724973 0.77
218 385 2h0b (A) 283 452 25.00 0 1 0.589514 -0.61
407 444 5ky9 (B) 455 490 42.00 0 0.98 0.393086 0.41
407 444 5kxh (B) 90 125 33.00 0 0.84 0.424086 0

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_133304)

Species Accession Gene Product
Brugia malayi Bm1_53440   UNC-52/Perlecan
Caenorhabditis elegans CELE_T19D12.6   Protein T19D12.6
Caenorhabditis elegans CELE_ZC101.2a   Protein UNC-52, isoform G
Drosophila melanogaster Dmel_CG8403   CG8403 gene product from transcript CG8403-RB
Echinococcus granulosus EgrG_000059400   pikachurin
Echinococcus multilocularis EmuJ_000059400   pikachurin
Homo sapiens ENSG00000164318   EGF-like, fibronectin type III and laminin G domains
Loa Loa (eye worm) LOAG_14788   UNC-52/Perlecan
Mus musculus ensembl-mmu:ENSMUSG00000042961   EGF-like, fibronectin type III and laminin G domains
Schistosoma japonicum Sjp_0109750   IPR006209,EGF-like;IPR013032,EGF-like region;IPR000742,EGF-like, type 3;IPR008985,Concanavalin A-like lectin/glucanase,domain-co
Schistosoma japonicum Sjp_0106770   EGF-like, fibronectin type-III and laminin G-like domain-containing protein precursor, putative
Schistosoma mansoni Smp_128590   laminin gamma-3 chain
Schmidtea mediterranea mk4.001504.05   Basement membrane-specific heparan sulfate proteoglycan core protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0029 1 1
0.0024 0.5 0.5
0.0049 0.2501 0.2501
0.0046 0.3702 0.5241
0.0218 0.3656 0.3656
0.0277 0.3252 0.3252
0.0028 0.5 0.5
0.0078 0.3631 0.2694
0.0051 1 0.5
0.00203233 1 1
0.0027 1 1
0.0023 0.5 0.5
0.0025 0.5 0.5
0.0078 0.3631 0.2694
0.0025 0.3891 0.3891
0.0277 0.3252 0.3252
0.0027 0.4212 1
0.0025 1 1
0.0218 0.3656 0.3656
0.0029 1 1
0.0027 0.4212 1
0.0026 1 1
0.0173 0.4278 0.4277
0.0077 1 1
0.0115 0.3005 0.3005
0.0345 0.4313 0.4313
0.0026 0.435 1
0.0054 0.5 0.5
0.0028 0.5 0.5
0.0078 0.3631 0.2694

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000059400 (Echinococcus granulosus), pikachurin
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