Detailed view for Rv0568

Basic information

TDR Targets ID: 5821
Mycobacterium tuberculosis, Possible cytochrome P450 135B1 Cyp135B1

Source Database / ID:  Tuberculist 

pI: 10.3652 | Length (AA): 472 | MW (Da): 50688 | Paralog Number: 3

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0009055   electron carrier activity  
GO:0005506   iron ion binding  
GO:0004497   monooxygenase activity  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 440 2ve3 (A) 9 442 25.00 0 1 1.26683 -0.51
6 35 2og5 (A) 85 114 53.00 0.72 0.29 0.472359 1.41
8 431 3czh (A) 38 492 20.00 0 1 1.15341 -0.43
9 454 4pxh (A) 8 420 17.00 0 1 1.01572 0.56

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Dormant phase. hasan
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. murphy
Show/Hide expression data references
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.

Orthologs

Ortholog group members (OG5_135997)

Species Accession Gene Product
Mycobacterium tuberculosis Rv0327c   Possible cytochrome P450 135A1 Cyp135A1
Mycobacterium tuberculosis Rv0568   Possible cytochrome P450 135B1 Cyp135B1
Mycobacterium tuberculosis Rv3685c   Probable cytochrome P450 137 Cyp137
Mycobacterium tuberculosis Rv0136   Probable cytochrome P450 138 Cyp138

Essentiality

Rv0568 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu576 this record Mycobacterium tuberculosis non-essential nmpdr
mtu3748 Mycobacterium tuberculosis non-essential nmpdr
mtu137 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 451 aa 26.8% 396 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0079 0.2909 0.5653
0.0145 0.7126 0.5
0.0388 0.2772 0.5
0.007 0.3303 0.4951
0.0038 1 0.5
0.0004 0.5 0.5
0.0075 0.3265 0
0.0004 0.5 0.5
0.0026 0.5 0.5
0.007 1 1
0.0102 0.3061 0.3937
0.0004 0.5 0.5
0.015 0.2827 0.5891
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0073 1 0.5
0.0331 0.3985 1
0.0004 0.5 0.5
0.000376403 0.5 0.5
0.0004 0.5 0.5
0.002 1 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0087 1 0.5
0.0004 0.5 0.5
0.0069 0.5 0.5
0.0073 1 0.5
0.0057 0.2766 1
0.0033 0.5 0.5
0.0103 0.6953 1
0.0004 0.5 0.5
0.0368 0.2796 1
0.0052 0.3769 0.5
0.0004 0.5 0.5
0.0068 0.4312 1
0.0111 0.3549 0.362
0.0004 0.5 0.5
0.0049 0.6682 0.5
0.0051 0.5 0.5
0.0062 0.5 0.5
0.0004 0.5 0.5
0.0346 0.2559 0.6171
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0027 1 1
0.0262 0.3083 1
0.0059 0.5 0.5
0.0042 1 0.5
0.0004 0.5 0.5
0.0016 1 0.5
0.0038 0.5 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0011 0.5 0.5
0.0051 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0019 0.271 0.5
0.0023 0.5 0.5
0.0012 0.5 0.5
0.015 0.2827 0.5891
0.0082 0.5 0.5
0.0081 0.5 0.5
0.0015 0.5 0.5
0.0059 0.6064 0.5
0.000376403 0.5 0.5
0.0067 0.5 0.5
0.0032 1 0.5
0.0008 0.5 0.5
0.00184047 0.269186 0.5
0.0065 1 0.5
0.0053 1 0.5
0.0119 0.4458 0.5
0.0176 0.3425 1
0.0162 0.2769 1
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0023 1 0.5
0.0388 0.2772 0.5
0.0023 1 1
0.0004 0.5 0.5
0.0018 1 0.5
0.007 1 1
0.0217 0.8044 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0084 0.3462 0.6551
0.0173 0.3858 0.5
0.0032 1 0.5
0.0004 0.5 0.5
0.0083 0.5 0.5
0.0092 0.467 0.5
0.004 0.5565 0.5
0.0004 0.5 0.5
0.0361 0.2704 0.5
0.0004 0.5 0.5
0.0284 0.2726 1
0.0057 0.2766 1
0.0004 0.5 0.5
0.0032 0.5 0.5
0.0004 0.5 0.5
0.0056 0.6399 0.5
0.0048 0.6634 0.5
0.0202 0.2702 0.5446
0.004 1 0.5
0.0004 0.5 0.5
0.0103 1 0.5
0.0011 0.5 0.5
0.0086 0.5 0.5
0.0033 0.2605 0.5
0.0075 1 0.5
0.0004 0.5 0.5
0.0137 0.271 1
0.0033 0.5 0.5
0.0007 0.5 0.5
0.0063 0.4653 0.5
0.0004 0.5 0.5
0.0042 0.3378 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.036 0.2841 0.7643
0.0058 0.5 0.5
0.0012 1 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5004 0.5
0.0004 0.5 0.5
0.0047 0.6689 0.5
0.0569 0.2624 1
0.0018 0.5 0.5
0.0284 0.2924 1
0.0316 0.2652 0.7504
0.0004 0.5 0.5
0.00777519 0.280873 1
0.0036 1 0.5
0.0047 0.6638 0.5
0.0059 0.6064 0.5
0.0019 0.5 0.5
0.0007 0.5 0.5
0.0063 0.5 0.5
0.0055 0.5 0.5
0.0184 0.3352 0.9605
0.0081 0.5 0.5
0.0018 0.3602 0.5
0.0004 0.5 0.5
0.0047 0.5 0.5
0.0316 0.2652 0.7504
0.0156 0.4244 1
0.0065 0.3393 0.3393
0.0071 0.9628 0.5
0.0029 1 0.5
0.0055 0.2887 0.5
0.00139338 1 0.5
0.0004 0.5 0.5
0.0021 0.4036 0
0.0133 0.2787 0.8245
0.005 0.5 0.5
0.0004 0.5 0.5
0.0065 0.5 0.5
0.0018 0.2876 0.5
0.0353 0.4928 0.5
0.0037 0.2694 1
0.0011 1 0.5
0.0036 0.4353 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.008 0.2582 1
0.006 0.2795 0.5
0.0007 0.5 0.5
0.0289 0.2916 1
0.0032 0.5 0.5
0.0034 0.337 1
0.033 0.3723 1
0.0341 0.2689 0.5
0.0019 0.271 0.5
0.026 0.251 1
0.015 0.3435 0.5
0.0004 0.5 0.5
0.0046 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0044 0.4237 0.5
0.0049 0.293 0.5
0.0071 0.5 0.5
0.0326 0.2819 0.5
0.01 0.5 0.5
0.0015 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0074 1 0.5
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0007 0.5 0.5
0.0007 0.5 0.5
0.00505219 0.5 0.5
0.0068 0.5 0.5
0.0228 0.2829 0.5
0.0004 0.5 0.5
0.0025 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0068 1 0.5
0.0011 0.5 0.5
0.0052 0.2829 0.5
0.0004 0.5 0.5
0.0122 0.4249 1
0.0075 0.2816 0.5
0.0018 0.5 0.5
0.0082 0.5 0.5
0.0051 0.3758 0.5
0.0046 0.6591 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0002 0.5 0.5
0.0082 0.5 0.5
0.0004 0.5 0.5
0.0066 1 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0189 0.5524 0.5
0.0004 0.5 0.5
0.004 1 0.5
0.003 0.3514 0.5
0.0004 0.5 0.5
0.0033 0.3348 0.5
0.0018 0.2637 0.5
0.0042 0.5 0.5
0.008 0.5 0.5
0.0008 0.5 0.5
0.0014 0.5 0.5
0.0235 0.3192 0.6178
0.0022 0.5 0.5
0.0059 0.5 0.5
0.0121 1 1
0.0004 0.5 0.5
0.0059 0.6064 0.5
0.0046 0.2608 0.5
0.00213675 0.269186 0.5
0.0004 0.5 0.5
0.0146 0.6654 0.5
0.0336 0.2847 0.5
0.0569 0.2624 1
0.004 1 0.5
0.0004 0.5 0.5
0.0028 0.2972 1
0.0004 0.5 0.5
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0124 0.2696 0.8052
0.0071 0.5 0.5
0.0004 0.5 0.5
0.0184 0.3508 0.5
0.0185 0.2528 0.5
0.0004 0.5 0.5
0.0036 0.5 0.5
0.000218985 0.5 0.5
0.0004 1 0.5
0.0286 1 1
0.0011 0.5 0.5
0.0011 0.5 0.5
0.0015 0.5 0.5
0.0203 0.2689 0.5
0.0022 0.5 0.5
0.0353 0.4928 0.5
0.0004 0.5 0.5
0.0173 0.3457 0
0.0052 0.3825 0.5
0.0029 0.5 0.5
0.0016 0.5 0.5
0.0048 1 0.5
0.0067 0.5 0.5
0.0027 0.5 0.5
0.0004 0.5 0.5
0.0103 0.4147 0.4168
0.034 0.2765 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0004 1 0.5
0.0167 0.2978 0.5
0.0004 0.5 0.5
0.0063 0.3886 0.5
0.0004 0.5 0.5
0.0119 0.5 0.5
0.0004 0.5 0.5
0.0323 0.2823 0.8288
0.003 0.3271 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0059 0.6064 0.5
0.0127 0.5337 0.5
0.0166 0.5366 0.5
0.0268 0.2982 1
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0166 0.2888 0
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0217 0.2742 0.5
0.0119 0.4458 0.5
0.0008 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0099 0.7122 0.5
0.0032 0.5 0.5
0.0004 0.5 0.5
0.002 0.5 0.5
0.0004 0.5 0.5
0.0076 1 1
0.0368 0.2796 1
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0022 0.3789 0.5
0.0078 1 0.5
0.0018 0.5 0.5
0.0037 0.4283 0.5
0.0078 0.3003 0.5792
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0011 0.5 0.5
0.008 1 0.5
0.0066 0.5 0.5
0.0004 0.5 0.5
0.0018 0.5004 0.5
0.0015 0.5 0.5
0.0048 0.6597 0.5
0.0331 0.3985 1
0.0093 0.5 0.5
0.0046 0.5 0.5
0.0072 1 0.5
0.0063 0.2543 0.5
0.0011 0.5 0.5
0.0235 0.2812 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0019 0.2756 0.5
0.0004 0.5 0.5
0.004 1 1
0.0038 0.525 0.5
0.0072 1 0.5
0.0004 0.5 0.5
0.0193 0.311 0
0.0084 1 0.5
0.0004 0.5 0.5
0.0047 0.6638 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0118 0.3485 0.5
0.0054 1 0.5
0.0023 0.5 0.5
0.0045 0.5 0.5
0.0093 0.3481 0.6382
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0084 0.5 0.5
0.0011 0.5 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.00213675 0.269186 0.5
0.0004 0.5 0.5
0.0106 0.2751 1
0.0025 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.000218985 0.5 0.5
0.0004 0.5 0.5
0.0104 0.5 0.5
0.0094 0.2887 0.5
0.0146 0.6069 0.5
0.0008 0.5 0.5
0.0027 1 0.5
0.0026 0.5 0.5
0.0046 0.6591 1
0.0197 0.6846 0.5
0.0092 1 0.5
0.0267 0.27 0.5
0.0056 0.3577 1
0.0083 0.6735 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.00109509 1 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0083 1 0.5
0.0174 0.2937 0.5
0.0004 0.5 0.5
0.0026 0.5 0.5
0.0008 0.5 0.5
0.0091 0.2951 1
0.0004 0.5 0.5
0.0062 0.2905 1
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.00451124 0.405669 0.5
0.0007 0.5 0.5
0.0114 1 0.5
0.0094 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0016 1 0.5
0.0021 0.5 0.5
0.0004 0.5 0.5
0.0019 0.5 0.5
0.0004 0.5 0.5
0.0008 1 0.5
0.00213675 0.269186 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0036 0.5 0.5
0.0443 0.3118 1
0.0004 0.5 0.5
0.004 1 0.5
0.0012 0.5 0.5
0.0044 0.6112 0.5
0.0216 0.2583 0.5
0.0099 0.7062 0.5
0.0007 1 0.5
0.0071 0.3514 0.5
0.0022 0.3489 0.5
0.0249 0.3082 0.5
0.0004 0.5 0.5
0.0003 0.5 0.5
0.0164 0.3784 0.5
0.0069 1 0.5
0.0007 1 0.5
0.0133 0.256 0.5
0.0323 0.3673 1
0.0071 0.2928 0.5
0.033 0.3723 1
0.0023 0.9674 0.5
0.0324 0.2701 1
0.0012 0.5 0.5
0.0065 1 0.5
0.0069 0.2847 0.4473
0.0035 0.4422 0.5
0.0044 0.2627 0
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.00213675 0.269186 0.5
0.0114 1 0.5
0.0004 1 0.5
0.000396385 0.5 0.5
0.0077 0.5 0.5
0.0284 0.2924 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0033 0.5 0.5
0.0051 0.4977 0.5
0.0011 1 0.5
0.0108 0.2733 1
0.005 0.3622 0.5
0.0004 0.5 0.5
0.0028 0.5 0.5
0.0157 0.3541 0.5
0.0063 0.5 0.5
0.0291 0.2657 0.5
0.005 0.2698 0.5
0.0038 0.5102 0.5
0.0028 0.5 0.5
0.0246 0.2667 0.5
0.0004 0.5 0.5
0.025 0.2789 0.5
0.0003 0.5 0.5
0.033 0.3723 1
0.026 0.251 1
0.008 0.2556 1
0.005 1 0.5
0.0054 0.5 0.5
0.0012 0.5 0.5
0.007 0.5713 0.5
0.0045 0.5 0.5
0.0004 0.5 0.5
0.0087 1 0.5
0.007 0.5 0.5
0.0011 1 0.5
0.0008 0.3317 0
0.0008 0.3317 0
0.0073 0.5 0.5
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0029 0.36 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Rv0568 (Mycobacterium tuberculosis), Possible cytochrome P450 135B1 Cyp135B1
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