Detailed view for EgrG_001169200

Basic information

TDR Targets ID: 582172
Echinococcus granulosus, irregular chiasm roughest protein
Source Database / ID:  GeneDB

pI: 8.3819 | Length (AA): 823 | MW (Da): 90246 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07686   Immunoglobulin V-set domain
PF08205   CD80-like C2-set immunoglobulin domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
72 366 4ofy (D) 20 268 27.00 0.00014 1 0.373745 1.12
73 311 4of8 (A) 30 218 35.00 0 1 0.346701 0.71
73 192 1pko (A) 5 117 22.00 0 0.91 0.354308 -0.6
74 177 2x6m (A) 4 102 17.00 0 0.71 0.243867 -0.99
143 586 5k6w (A) 42 463 24.00 0.00003 1 0.44679 1.7
157 277 1qz1 (A) 155 259 39.00 0.023 0.37 0.208323 1.33
330 588 1cs6 (A) 9 290 31.00 0.000049 1 0.245002 1.77
435 482 5fm5 (O) 260 323 46.00 0.59 0.52 0.240623 -0.23
497 594 1u2h (A) 17 109 26.00 0 0.8 0.288577 0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130832)

Species Accession Gene Product
Brugia malayi Bm1_38455   Immunoglobulin I-set domain containing protein
Caenorhabditis elegans CELE_K02E10.8   Protein SYG-1, isoform B
Drosophila melanogaster Dmel_CG3653   kin of irre
Drosophila melanogaster Dmel_CG4125   roughest
Echinococcus granulosus EgrG_001169200   irregular chiasm roughest protein
Echinococcus multilocularis EmuJ_001169200   irregular chiasm roughest protein immunoglobulin set domain containing protein
Homo sapiens ENSG00000149571   kin of IRRE like 3 (Drosophila)
Homo sapiens ENSG00000183853   kin of IRRE like (Drosophila)
Loa Loa (eye worm) LOAG_03869   immunoglobulin I-set domain-containing protein
Mus musculus ENSMUSG00000041734   kin of IRRE like (Drosophila)
Mus musculus ENSMUSG00000032036   kin of IRRE like 3 (Drosophila)
Schistosoma japonicum Sjp_0057460   Irregular chiasm C-roughest protein precursor, putative
Schistosoma mansoni Smp_104390   nephrin related
Schmidtea mediterranea mk4.027566.02  
Schmidtea mediterranea mk4.031189.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0073 0.7191 1
0.016 0.6756 1
0.0449 0.6473 1
0.008 0.6771 0.6935
0.0081 0.5905 0.5807
0.008 0.5741 0.5741
0.0079 0.5265 0.5265
0.0106 0.5026 0.5729
0.0049 0.721 1
0.0197 0.4388 1
0.0053 0.7046 0.5
0.0074 0.355 0.3409
0.0314 0.2806 0.2788
0.0085 0.2559 0.2559
0.0054 0.7018 0.5
0.0074 0.2817 0.2747
0.008 0.6062 0.5962
0.0074 0.3192 0.3389
0.0303 0.4809 0.506
0.0101 0.6716 1
0.0079 0.5275 0.5275
0.0238 0.2699 0.5048
0.0452 0.7107 1
0.0049 0.6979 1
0.0077 0.6236 1
0.008 0.5441 0.5441
0.0286 0.376 0.9158
0.0269 0.3521 1
0.0129 0.4117 0.1662
0.0238 0.2699 0.5048
0.0074 0.2817 0.2747
0.0224 0.4315 0.7155
0.0075 0.7193 1
0.0031 0.476 1
0.0304 0.3987 0.892
0.0076 0.6149 1
0.0081 0.6423 0.6152
0.0072 0.4307 0.4307
0.0076 0.6267 0.6162
0.0049 0.721 1
0.0129 0.4117 0.1662
0.0161 0.32 0.3149
0.0266 0.3002 0.3002
0.0054 0.2535 0.2511
0.0372 0.6637 1
0.0078 0.5863 0.5758
0.0075 0.4288 0.4288
0.0385 0.6376 1
0.0134 0.4433 1
0.0129 0.4117 0.1662
0.0348 0.6176 0.8043
0.0238 0.2699 0.5048
0.008 0.6326 1
0.0106 0.5026 0.5729
0.0253 0.4155 0.8985
0.0253 0.379 1
0.0133 0.2555 0.2555
0.0298 0.3987 0.8247
0.0039 0.4857 0.4857
0.0393 0.4766 1
0.0129 0.4117 0.1662
0.0072 0.7303 1
0.0054 0.3822 0.3822
0.008 0.5741 0.5741
0.0073 0.3578 0.3578
0.0225 0.6261 1
0.0076 0.7193 1
0.0018 0.4938 1
0.009 0.4863 1
0.0153 0.6731 0.9822
0.0054 0.7018 0.5
0.0225 0.6261 1
0.0289 0.4698 0.5755
0.0018 0.5533 1
0.0077 0.5524 0.5
0.0303 0.4809 0.506
0.0494 0.5335 1
0.0135 0.5155 0.7871
0.0054 0.4651 1
0.0109 0.721 1
0.0364 0.3245 1
0.0409 0.4427 0.4876
0.0342 0.6198 1
0.0039 0.5152 0.5152
0.0458 0.6828 1
0.014 0.2948 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001169200 (Echinococcus granulosus), irregular chiasm roughest protein
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