Detailed view for EgrG_000945550

Basic information

TDR Targets ID: 582371
Echinococcus granulosus, tyrosine protein phosphatase non receptor type
Source Database / ID:  GeneDB

pI: 6.1099 | Length (AA): 1768 | MW (Da): 192600 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00102   Protein-tyrosine phosphatase
PF03097   BRO1-like domain
PF13949   ALIX V-shaped domain binding to HIV

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  
GO:0004725   protein tyrosine phosphatase activity  
GO:0006470   protein amino acid dephosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 566 2xs1 (A) 146 694 24.00 0 1 0.502536 0.31
1 230 5mk2 (A) 140 361 37.00 0 1 0.508491 0.15
236 577 5lm2 (B) 7 345 31.00 0 1 0.593839 -0.37
349 474 2i1k (A) 336 470 22.00 0.99 0.41 0.383667 -0.58
1294 1649 1ygr (A) 650 952 19.00 0.56 0.78 0.162557 1.01
1298 1373 4ikc (A) 2708 2779 47.00 0.00000012 0.1 0.366386 0.7
1299 1542 2cm2 (A) 43 233 35.00 0.0000043 1 0.260409 0.11
1299 1573 1wch (A) 2240 2456 29.00 0.00000014 1 0.165943 0.23
1299 1566 1l8k (A) 45 239 37.00 0.0000005 0.96 0.178984 0.52
1423 1588 2cjz (A) 360 535 17.00 0.31 0.37 0.274091 -0.09

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131141)

Species Accession Gene Product
Brugia malayi Bm1_07770   hypothetical protein
Candida albicans CaO19.9239   BCK1-like resistance to osmotic shock
Candida albicans CaO19.1670   BCK1-like resistance to osmotic shock
Caenorhabditis elegans CELE_Y53H1C.2   Protein EGO-2, isoform A
Drosophila melanogaster Dmel_CG9311   myopic
Echinococcus granulosus EgrG_000945550   tyrosine protein phosphatase non receptor type
Echinococcus multilocularis EmuJ_000945550  
Homo sapiens ENSG00000076201   protein tyrosine phosphatase, non-receptor type 23
Loa Loa (eye worm) LOAG_08219   hypothetical protein
Loa Loa (eye worm) LOAG_08220   hypothetical protein
Mus musculus ENSMUSG00000036057   protein tyrosine phosphatase, non-receptor type 23
Saccharomyces cerevisiae YPL084W   Bro1p
Schistosoma japonicum Sjp_0001220   ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative
Schistosoma mansoni Smp_075810   pcd6 interacting protein-related
Schmidtea mediterranea mk4.000834.01   Tyrosine-protein phosphatase non-receptor type 23
Schmidtea mediterranea mk4.000834.04  
Schmidtea mediterranea mk4.000834.05  
Schmidtea mediterranea mk4.000556.04  
Schmidtea mediterranea mk4.000834.02  

Essentiality

EgrG_000945550 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y53H1C.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y53H1C.2 Caenorhabditis elegans larval arrest wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0011 1 0.5
0.0011 1 1
0.0011 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000945550 (Echinococcus granulosus), tyrosine protein phosphatase non receptor type
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