Detailed view for EgrG_000938800

Basic information

TDR Targets ID: 584466
Echinococcus granulosus, C2 calcium dependent membrane targeting
Source Database / ID:  GeneDB

pI: 8.4675 | Length (AA): 1351 | MW (Da): 146492 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00168   C2 domain
PF00595   PDZ domain (Also known as DHR or GLGF)

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

Insulin secretion (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
127 169 2cjs (C) 92 137 51.00 0.0000014 0.73 0.524228 0.21
510 587 2fne (A) 1967 2042 32.00 0 1 0.503235 -0.94
523 579 2yuy (A) 59 109 45.00 0.62 1 0.436591 0.36
529 577 2ego (A) 132 179 42.00 0.26 1 0.526669 0
635 754 4mjj (A) 93 215 27.00 0 1 0.318323 -0.22
1161 1298 2q3x (A) 1447 1583 57.00 0 1 0.763647 -1.04

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130564)

Species Accession Gene Product
Brugia malayi Bm1_08610   hypothetical protein
Caenorhabditis elegans CELE_T10A3.1   Protein UNC-10, isoform B
Drosophila melanogaster Dmel_CG33547   Rab3 interacting molecule
Echinococcus granulosus EgrG_000938800   C2 calcium dependent membrane targeting
Echinococcus multilocularis EmuJ_000938800   C2 calcium dependent membrane targeting
Homo sapiens ENSG00000079841   regulating synaptic membrane exocytosis 1
Homo sapiens ENSG00000176406   regulating synaptic membrane exocytosis 2
Loa Loa (eye worm) LOAG_09444   hypothetical protein
Loa Loa (eye worm) LOAG_10182   hypothetical protein
Loa Loa (eye worm) LOAG_09445   hypothetical protein
Loa Loa (eye worm) LOAG_10181   hypothetical protein
Loa Loa (eye worm) LOAG_13756   hypothetical protein
Mus musculus 116838   regulating synaptic membrane exocytosis 2
Mus musculus 116837   regulating synaptic membrane exocytosis 1
Schistosoma japonicum Sjp_0010690   Regulating synaptic membrane exocytosis protein 1, putative
Schistosoma mansoni Smp_155260   rab3 interacting molecule (rim)-related
Schmidtea mediterranea mk4.025303.00   Rab-3-interacting molecule unc-10
Schmidtea mediterranea mk4.020010.00  
Schmidtea mediterranea mk4.003377.03  
Schmidtea mediterranea mk4.003377.04   HMG-CoA synthase
Schmidtea mediterranea mk4.015147.00  
Schmidtea mediterranea mk4.010867.03   Rim
Schmidtea mediterranea mk4.021802.02   Rim

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0018 0.5 0.5
0.0125 0.3893 0.9758
0.0121 1 1
0.0071 0.2549 0.2498
0.0057 0.3491 0.3491
0.0107 0.5 0.5
0.0058 0.5 0.5
0.0109 0.4866 0.4866
0.0072 0.2639 0.2639
0.005 0.2612 0.2612

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000938800 (Echinococcus granulosus), C2 calcium dependent membrane targeting
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