Detailed view for EgrG_000438400

Basic information

TDR Targets ID: 584684
Echinococcus granulosus, S formylglutathione hydrolase
Source Database / ID:  GeneDB

pI: 6.3296 | Length (AA): 283 | MW (Da): 31928 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00756   Putative esterase

Gene Ontology

Mouse over links to read term descriptions.
GO:0046294   formaldehyde catabolic process  
GO:0018738   S-formylglutathione hydrolase activity  

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 282 3fcx (A) 1 282 55.00 0 1 1.71527 -1.3
2 282 3i6y (A) 2 279 53.00 0 1 1.75373 -1.52
3 281 3ls2 (A) 2 279 51.00 0 1 1.71667 -1.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129182)

Species Accession Gene Product
Arabidopsis thaliana AT2G41530   S-formylglutathione hydrolase
Brugia malayi Bm1_17620   Esterase D
Candida albicans CaO19.6596   esterase motif
Caenorhabditis elegans CELE_Y48G10A.1   Protein Y48G10A.1
Dictyostelium discoideum DDB_G0283037   S-formylglutathione hydrolase
Drosophila melanogaster Dmel_CG4390   CG4390 gene product from transcript CG4390-RB
Escherichia coli b0355   S-formylglutathione hydrolase
Escherichia coli b2154   S-formylglutathione hydrolase
Echinococcus granulosus EgrG_000438400   S formylglutathione hydrolase
Echinococcus multilocularis EmuJ_000438400   S formylglutathione hydrolase
Homo sapiens ENSG00000139684   esterase D
Loa Loa (eye worm) LOAG_10965   esterase D
Mus musculus ENSMUSG00000021996   esterase D/formylglutathione hydrolase
Oryza sativa 4326513   Os01g0939700
Saccharomyces cerevisiae YJL068C   S-formylglutathione hydrolase
Schmidtea mediterranea mk4.003304.04   S-formylglutathione hydrolase
Schmidtea mediterranea mk4.005085.04   S-formylglutathione hydrolase
Schmidtea mediterranea mk4.005085.02  
Schmidtea mediterranea mk4.003304.02  

Essentiality

EgrG_000438400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0355 Escherichia coli non-essential goodall
b2154 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Sus scrofa Esterase D Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0136 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000438400 (Echinococcus granulosus), S formylglutathione hydrolase
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