Detailed view for EgrG_001178700

Basic information

TDR Targets ID: 584997
Echinococcus granulosus, PIK kinase FAT and Armadillo domain containing protein
Source Database / ID:  GeneDB

pI: 7.2877 | Length (AA): 4562 | MW (Da): 504772 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02259   FAT domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016573   histone acetylation  
GO:0000123   histone acetyltransferase complex  
GO:0005634   nucleus  
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

HTLV-I infection (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
146 1406 1u6g (C) 17 1210 13.00 0 0.99 0.153914 1.1
416 1169 5ife (C) 480 1196 11.00 0.000000024 0.39 0.0467784 0.66
1996 2777 1qgr (A) 16 775 10.00 0 0.81 0.205216 0.36
2001 2927 4c0p (A) 25 916 11.00 0 1 0.225 0.37
3260 3373 5hrz (A) 5 118 10.00 0.092 0.01 0.115489 -0.61
3964 4080 2pwy (A) 14 115 36.00 0.12 0.54 0.123147 1.14

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128900)

Species Accession Gene Product
Arabidopsis thaliana AT4G36080   phosphotransferases/inositol or phosphatidylinositol kinases
Arabidopsis thaliana AT2G17930   phosphatidylinositol 3- and 4-kinase family protein with FAT domain
Babesia bovis BBOV_III007660   hypothetical protein
Brugia malayi Bm1_43835   FAT domain containing protein
Candida albicans CaO19.3451   similar to C terminus of S. cerevisiae TRA1 (YHR099W) histone acetyltransferase complex component
Candida albicans CaO19.139   similar to N terminus of S. cerevisiae TRA1 (YHR099W) histone acetyltransferase complex component
Candida albicans CaO19.10955   similar to C terminus of S. cerevisiae TRA1 (YHR099W) histone acetyltransferase complex component
Candida albicans CaO19.7783   similar to N terminus of S. cerevisiae TRA1 (YHR099W) histone acetyltransferase complex component
Caenorhabditis elegans CELE_C47D12.1   Protein TRR-1, isoform C
Cryptosporidium hominis Chro.60211   phosphatidylinositol kinase-like protein
Cryptosporidium parvum cgd6_1740   Tra1p-like; C-terminal FAT domain plus phoshoinositide 3-kinase domain; very large protein
Dictyostelium discoideum DDB_G0281947   PIKK family protein kinase
Drosophila melanogaster Dmel_CG33554   CG33554 gene product from transcript CG33554-RE
Echinococcus granulosus EgrG_001178700   PIK kinase FAT and Armadillo domain containing protein
Echinococcus multilocularis EmuJ_001178700   PIK kinase, FAT and Armadillo domain containing protein
Homo sapiens ENSG00000196367   transformation/transcription domain-associated protein
Loa Loa (eye worm) LOAG_08898   hypothetical protein
Loa Loa (eye worm) LOAG_04605   hypothetical protein
Loa Loa (eye worm) LOAG_03414   hypothetical protein
Loa Loa (eye worm) LOAG_11724   hypothetical protein
Mus musculus ENSMUSG00000045482   transformation/transcription domain-associated protein
Neospora caninum NCLIV_037840   hypothetical protein
Oryza sativa 4344092   Os07g0645100
Oryza sativa 9270052   Os07g0645200
Saccharomyces cerevisiae YHR099W   Tra1p
Schistosoma japonicum Sjp_0039160   ko:K08874 transformation/transcription domain-associated protein, putative
Schistosoma mansoni Smp_135260   choline/ethanolaminephosphotransferase 1
Schmidtea mediterranea mk4.006712.07  
Schmidtea mediterranea mk4.036138.00   Transcription-associated protein 1
Schmidtea mediterranea mk4.006712.00  
Schmidtea mediterranea mk4.016941.00   Transcription-associated protein 1
Schmidtea mediterranea mk4.006712.01   Transcription-associated protein 1
Schmidtea mediterranea mk4.006712.06  
Schmidtea mediterranea mk4.006712.04  
Schmidtea mediterranea mk4.006712.05   Transcription-associated protein 1
Toxoplasma gondii TGME49_268370   non-specific serine/threonine protein kinase
Theileria parva TP04_0665   hypothetical protein

Essentiality

EgrG_001178700 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C47D12.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_C47D12.1 Caenorhabditis elegans larval arrest wormbase
CELE_C47D12.1 Caenorhabditis elegans larval lethal wormbase
CELE_C47D12.1 Caenorhabditis elegans slow growth wormbase
CELE_C47D12.1 Caenorhabditis elegans sterile wormbase
YHR099W Saccharomyces cerevisiae inviable yeastgenome
TGME49_268370 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_001178700 (Echinococcus granulosus), PIK kinase FAT and Armadillo domain containing protein
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