Detailed view for EgrG_000706500

Basic information

TDR Targets ID: 585634
Echinococcus granulosus, beta 1 syntrophin
Source Database / ID:  GeneDB

pI: 7.7985 | Length (AA): 521 | MW (Da): 57832 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00169   PH domain
PF00595   PDZ domain (Also known as DHR or GLGF)

Gene Ontology

Mouse over links to read term descriptions.
GO:0050808   synapse organization and biogenesis  
GO:0016010   dystrophin-associated glycoprotein complex  
GO:0005515   protein binding  
GO:0005198   structural molecule activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 251 1z87 (A) 9 262 29.00 0 1 0.614788 1.2
56 142 4jok (A) 284 370 40.00 0.025 1 0.778687 -1.31
61 149 2vrf (A) 116 204 53.00 0 1 0.870125 -0.81
71 164 4wyu (A) 24 118 46.00 0.000001 1 0.542722 -0.04
106 135 2eei (A) 54 83 47.00 0.1 0.91 0.621882 -0.15
277 417 5d3x (A) 250 394 16.00 0 0.87 0.481133 -0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131930)

Species Accession Gene Product
Brugia malayi Bm1_41905   Syntrophin-1
Caenorhabditis elegans CELE_F30A10.8   Protein STN-1, isoform B
Drosophila melanogaster Dmel_CG7152   Syntrophin-like 1
Echinococcus granulosus EgrG_000706500   beta 1 syntrophin
Echinococcus multilocularis EmuJ_000706500   beta 1 syntrophin
Homo sapiens ENSG00000168807   syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
Homo sapiens ENSG00000172164   syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
Loa Loa (eye worm) LOAG_03578   syntrophin-1
Mus musculus ENSMUSG00000060429   syntrophin, basic 1
Mus musculus ENSMUSG00000041308   syntrophin, basic 2
Schistosoma japonicum Sjp_0052520   Beta-1-syntrophin, putative
Schistosoma japonicum Sjp_0110250   IPR001478,PDZ/DHR/GLGF,domain-containing
Schistosoma mansoni Smp_126310   syntrophin
Schmidtea mediterranea mk4.014782.01  
Schmidtea mediterranea mk4.011938.02   Syntrophin-1
Schmidtea mediterranea mk4.014782.00   Syntrophin-1
Schmidtea mediterranea mk4.024351.00  
Schmidtea mediterranea mk4.011938.00  

Essentiality

EgrG_000706500 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F30A10.8 Caenorhabditis elegans larval arrest wormbase
CELE_F30A10.8 Caenorhabditis elegans larval lethal wormbase
CELE_F30A10.8 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EgrG_000706500 (Echinococcus granulosus), beta 1 syntrophin
Title for this comment
Comment