Detailed view for EgrG_000417200

Basic information

TDR Targets ID: 586466
Echinococcus granulosus, fatty acid binding protein FABP2
Source Database / ID:  GeneDB

pI: 6.9867 | Length (AA): 176 | MW (Da): 19697 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0008289   lipid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 139 1o8v (A) 1 133 39.00 0 1 1.28227 -0.7
1 137 4tkb (A) 1 130 32.00 0 1 1.22271 -1.21
1 140 4i3b (A) 2 139 30.00 0.000000061 1 0.987055 -0.18
2 138 1yiv (A) 2 131 31.00 0 1 1.20371 -1.12
2 138 4bvm (A) 2 131 32.00 0 1 1.21001 -0.98
2 138 1g7n (A) 2 131 35.00 0 1 1.25291 -0.92
4 138 5gge (A) 3 130 40.00 0 1 1.28365 -0.93

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1O8V:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129604)

Species Accession Gene Product
Caenorhabditis elegans CELE_W02D3.7   Protein LBP-5
Caenorhabditis elegans CELE_W02D3.5   Protein LBP-6
Drosophila melanogaster Dmel_CG6783   fatty acid bindin protein
Echinococcus granulosus EgrG_000549800   fatty acid binding protein FABP2
Echinococcus granulosus EgrG_000550000   fatty acid binding protein, adipocyte
Echinococcus granulosus EgrG_000417200   fatty acid binding protein FABP2
Echinococcus granulosus EgrG_000549850   fatty acid binding protein FABP2
Echinococcus multilocularis EmuJ_000549800   fatty acid binding protein FABP2
Echinococcus multilocularis EmuJ_000417200   fatty acid binding protein FABP2
Echinococcus multilocularis EmuJ_000550000   fatty acid binding protein FABP2
Homo sapiens ENSG00000164434   fatty acid binding protein 7, brain
Homo sapiens 2170   fatty acid binding protein 3, muscle and heart
Homo sapiens ENSG00000147588   peripheral myelin protein 2
Mus musculus 14077   fatty acid binding protein 3, muscle and heart
Mus musculus ENSMUSG00000052468   peripheral myelin protein 2
Mus musculus ENSMUSG00000019874   fatty acid binding protein 7, brain
Schistosoma japonicum Sjp_0200770   ko:K08756 fatty acid-binding protein 7, brain, putative
Schistosoma japonicum Sjp_0314900   Fatty acid-binding protein, putative
Schistosoma mansoni Smp_095360.4   fatty acid binding protein
Schistosoma mansoni Smp_095360.1   fatty acid binding protein
Schmidtea mediterranea mk4.002794.04  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens fatty acid binding protein 3, muscle and heart Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Fatty acid-binding protein, adipocyte 132 aa 34.3% 137 aa Compounds References
Gallus gallus Cellular retinoic acid-binding protein I 137 aa 31.7% 145 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.00897187 0.301749 0.455261
0.0049 0.2958 0.2958

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000417200 (Echinococcus granulosus), fatty acid binding protein FABP2
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