Detailed view for Rv2763c

Basic information

TDR Targets ID: 5868
Mycobacterium tuberculosis, Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)

Source Database / ID:  Tuberculist 

pI: 6.7235 | Length (AA): 159 | MW (Da): 17640 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00186   Dihydrofolate reductase

Gene Ontology

Mouse over links to read term descriptions.
GO:0050661   NADP binding  
GO:0004146   dihydrofolate reductase activity  
GO:0055114   oxidation reduction  
GO:0046654   tetrahydrofolate biosynthetic process  
GO:0009165   nucleotide biosynthetic process  
GO:0006545   glycine biosynthetic process  

Metabolic Pathways

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 159 4klx (A) 1 159 99.99 0 1 2.243 -1.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 1DF7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1DG5:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1DG7:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 1DG8:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2CIG:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2W3V:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2W3W:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KL9:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KLX:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KM0:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KM2:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4KNE:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 4M2X:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5JA3:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5U26:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5U27:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 5UJF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 6DDP:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 6DDS:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 6DDW:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Dormant phase. murphy
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile Dormant phase. hasan
Show/Hide expression data references
  • hasan Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis.
  • murphy Identification of gene targets against dormant phase Mycobacterium tuberculosis infections.

Orthologs

Ortholog group members (OG5_128410)

Species Accession Gene Product
Arabidopsis thaliana AT2G21550   bifunctional dihydrofolate reductase/thymidylate synthase
Brugia malayi Bm1_48330   Dihydrofolate reductase
Brugia malayi Bm1_54930   dihydrofolate reductase family protein
Candida albicans CaO19.12607   dihydrofolate reductase
Candida albicans CaO19_5142   hypothetical protein
Candida albicans CaO19.5142   dihydrofolate reductase
Caenorhabditis elegans CELE_C36B1.7   Protein DHFR-1
Chlamydia trachomatis CT_612   dihydrofolate reductase
Dictyostelium discoideum DDB_G0286755   dihydrofolate reductase
Drosophila melanogaster Dmel_CG14887   Dihydrofolate reductase
Escherichia coli b0048   dihydrofolate reductase
Echinococcus granulosus EgrG_000572400   dihydrofolate reductase
Echinococcus multilocularis EmuJ_000572400   dihydrofolate reductase
Homo sapiens ENSG00000228716   dihydrofolate reductase
Loa Loa (eye worm) LOAG_03468   dihydrofolate reductase
Mycobacterium leprae ML1518c   DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)
Mus musculus ENSMUSG00000021707   dihydrofolate reductase
Mycobacterium tuberculosis Rv2763c   Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)
Mycobacterium ulcerans MUL_2179   dihydrofolate reductase DfrA
Saccharomyces cerevisiae YOR236W   dihydrofolate reductase
Schistosoma japonicum Sjp_0071810   ko:K00287 dihydrofolate reductase [EC1.5.1.3], putative
Schistosoma mansoni Smp_175230   dihydrofolate reductase
Schmidtea mediterranea mk4.001198.04   Dihydrofolate reductase

Essentiality

Rv2763c has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0048 Escherichia coli essential goodall
CELE_C36B1.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_C36B1.7 Caenorhabditis elegans sterile wormbase
YOR236W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 0   5089   216208  
Annotator: crowther@u.washington.edu. Comment: 2007-12-04. References: 16648861
response to drug (GO:0042493) decreased sensitivity toward (PATO:0001550) inferred from over expression (ECO:0000120) Mycobacterium smegmatis 5089   216208  
Annotator: crowther@u.washington.edu. Comment: 2007-12-04. References: 16648861
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium phlei 1669   1763   48945   59943   354733   547983   572016   572017  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 3741386
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium leprae 40810  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 2193064
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium leprae 0   28525   40810  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 10219472 10493608 2193064
growth (GO:0040007) decreased (PATO:0000468) inferred from animal model system (ECO:0000179) Mycobacterium leprae 0   28525   40810  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 10219472 11814771 2193064
response to drug (GO:0042493) decreased sensitivity toward (PATO:0001550) inferred from gain-of-function mutant phenotype (ECO:0000042) Mycobacterium smegmatis 1669   354733  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 2009922
catalytic activity (GO:0003824) drug insensitive (PATO:0000528) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium smegmatis 1669   354733  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 2009922
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium avium 0   28160   28500   28907   28908   29048   29181   29604   29698   29700   221861   546982   547263   549260   550230   550231   550232   552445   558244   562672   564860   567815   567816   577217  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 10052907 10991861 14998335 7486934 8913480 9835537
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 0   1669   28160   28500   28907   28908   29048   29181   29604   29698   29700   354733   535156   535157   535163   547263   549260   550230   550231   550232   552445   558244   562672   567032   567033   567435   567436   567437   567815   567816   577217   578029   579183   586541  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 10579848 10991861 11754594 12467708 12699390 12832132 14998335 15026078 15115391 15214795 15974594 17010625 9554874
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis 0   28160   28500   28908   29181   221861   550230   550231   550232   564860  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 10052907 11597474 12384337
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium ulcerans 28525  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 11152437
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) 0   221861   564860  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 12384337
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis 1669   1763   48945   59943   354733   547983   572016   572017  
Annotator: crowther@u.washington.edu. Comment: 2007-12-27. References: 15019741
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium avium 0   589269  
Annotator: crowther@u.washington.edu. Comment: 2007-12-28. References: 17017990 17552508 17569517
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-28. References: 17017990
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium avium 0  
Annotator: crowther@u.washington.edu. Comment: 2007-12-28. References: 17017990 17569517
growth (GO:0040007) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-28. References: 17017990
catalytic activity (GO:0003824) decreased (PATO:0000468) inferred from in vitro culture assay (ECO:0000182) Mycobacterium tuberculosis No drug identifiers listed for this gene.
Annotator: crowther@u.washington.edu. Comment: 2007-12-28. References: 17451962

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7


Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mycobacterium avium Dihydrofolate reductase Compounds References
Neisseria gonorrhoeae Dihydrofolate reductase Compounds References
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcuslactis) Dihydrofolate reductase Compounds References
Staphylococcus aureus subsp. aureus MW2 Dihydrofolate reductase Compounds References
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) Compounds References
Homo sapiens dihydrofolate reductase Compounds References
Bos taurus Dihydrofolate reductase Compounds References
Staphylococcus aureus Dihydrofolate reductase Compounds References
Salmonella enterica subsp. enterica serovar Typhi Dihydrofolate reductase Compounds References
Lactobacillus casei Dihydrofolate reductase Compounds References
Bacillus anthracis Dihydrofolate reductase Compounds References
Enterococcus faecium Dihydrofolate reductase Compounds References
Mus musculus dihydrofolate reductase Compounds References
Saccharomyces cerevisiae dihydrofolate reductase Compounds References
Candida albicans dihydrofolate reductase Compounds References
Gallus gallus Dihydrofolate reductase Compounds References
Escherichia coli dihydrofolate reductase Compounds References
Rattus norvegicus Dihydrofolate reductase Compounds References
Pneumocystis carinii Dihydrofolate reductase Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Escherichia coli Dihydrofolate reductase 157 aa 29.4% 160 aa Compounds References
Escherichia coli Dihydrofolate reductase type 1 157 aa 29.6% 142 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0748 0.6966 1
2.0501 1 1
0.0681 0.9883 1
0.0415 1 0.5
1.5911 1 1
0.0714 1 1
0.06 0.4105 1
0.058 1 1
0.5383 1 1
0.0619 1 1
0.3535 1 1
1.2952 1 1
0.0415 0.5 0.5
0.2997 1 1
1.2103 1 1
0.4336 0.4357 0.5651
0.0623 0.7614 0.9729
0.0676 1 1
2.2986 0.7708 1
0.2087 0.5 0.5
0.1787 1 0.5
0.3555 0.5313 0.6753
0.0883 1 1
0.1608 1 0.5
0.6026 0.2546 1
0.4282 1 0.5
0.4939 1 1
0.0208 0.4998 1
0.5564 0.3616 1
0.0176 1 0.5
1.6587 1 1
0.0977 0.4892 0.5
0.0379 1 1
1.8733 1 1
0.2773 0.7208 1
0.0338 0.4731 1
0.0104 1 0.5
0.0732 0.6833 0.9546
0.542 1 1
0.083 0.9519 1
0.0415 0.7924 0.5
2.0112 1 1
0.2208 0.541 0.4549
0.5154 1 1
0.144 1 0.5
1.0186 1 1
0.0415 1 0.5
0.1988 1 0.5
0.0437 0.9936 1
1.4822 1 1
0.0728 1 1
0.1328 1 1
0.0217 0.4692 1
0.1527 1 0.5
0.0376 0.4464 1
0.026 0.9737 0.9931
0.026 0.9883 1
0.2077 0.5 0.5
0.1363 0.6274 1
0.038 0.7413 1
0.0415 0.3184 1
0.7865 1 1
0.4593 1 1
0.0521 0.2747 0.3791
0.1922 1 1
1.1087 1 1
0.5564 0.3616 1
0.9217 1 1
0.7639 1 1
0.0447 0.3911 0.4953
2.0972 1 1
0.1772 1 1
0.3071 1 1
0.0676 1 1
0.0371 0.5 0.5
0.034 0.9927 1
0.0468 1 1
0.0208 1 0.5
0.5214 1 1
0.113252 1 1
0.0755 0.3411 1
0.034 0.5847 1
0.8806 0.4171 1
0.1532 1 1
0.7981 1 1
0.0872 1 1
0.5428 1 1
0.8741 1 1
1.1553 1 1
0.182 1 1
0.653 1 1
0.026 0.4925 1
0.1449 0.5 0.5
0.0348 1 1
0.6084 0.9151 1
1.5569 1 1
0.3903 0.295 1
0.0415 0.8752 1
0.1054 1 1
0.0548 0.5587 0.5
0.0215 0.2713 0
0.1017 0.8363 1
0.0963 0.8485 0.5
0.0349 0.5 0.5
0.0404 0.4452 0.7995
0.0727 1 0.5
0.9669 1 1
1.0229 0.4133 1
1.0229 0.4133 1
1.4106 1 1
0.165847 1 0.5
0.4999 0.3497 0.4047
0.2899 0.3946 1
1.2916 1 1
0.2151 1 1
0.0623 1 0.5
0.0415 0.5 0.5
0.0208 0.5 0.5
0.0623 0.2647 0.5
0.1338 0.739 1
0.0468 0.7441 0.9657
0.117 1 1
0.0368 0.5 0.5
0.1028 1 1
2.1159 1 1
0.7417 1 1
2.2986 0.7708 1
0.0257 1 0.5
0.2048 0.6872 1
0.026 0.9883 1
0.0439 1 1
0.0583 1 0.5
0.026 0.3213 1
0.1146 1 1
1.4106 1 1
0.026 0.9883 1
1.3778 1 1
0.0415 1 1
0.2517 1 1
0.055 1 1
0.0513 1 0.5
0.147 0.9939 1
1.2201 1 1
0.026 0.7415 1
0.7877 1 1
0.0569 1 1
0.3324 1 0.5
0.0404 1 0.5
0.0435 0.5553 1
1.4485 1 1
0.2156 0.5 0.5
0.46 0.5217 1
0.038 0.2813 0.6506
0.1148 1 1
0.0537 1 0.5
0.0547 1 1
0.5463 1 0.5
0.1813 0.4093 0.4903
0.4723 1 1
0.0638 0.2849 0.4022
0.0208 0.3336 0.7017
0.5407 1 1
1.1327 1 1
0.0328 0.4826 1
0.094 1 1
2.1995 0.6083 0.8155
1.2269 1 1
0.0544 1 0.5
0.0676 1 1
0.0668 1 1
0.0685 0.7533 1
0.1274 1 1
0.0547 0.8861 1
1.1845 1 1
1.9117 0.9134 1
1.457 0.3108 1
0.0676 1 0.5
1.3007 1 1
0.0156 0.262 0.3747
1.6782 0.963 0.963
0.0342 1 0.5
0.4961 1 1
0.0339 0.3317 1
0.1681 1 1
0.0884 1 0.5
0.1222 1 1
0.4062 1 1
0.0351 1 0.5
1.4745 1 1
0.0355 0.5105 1
0.5797 1 0.5
0.4813 0.268 1
1.9117 0.9134 1
0.3968 1 1
0.0197 0.982 1
0.1232 1 1
0.5927 1 1
0.2813 1 1
0.0183 1 0.5
0.1796 1 1
0.2351 0.3673 0.5604
0.4538 1 1
0.1718 0.5 0.5
0.0468 1 1
0.1948 1 0.5
0.1404 0.5 0.5
0.0415 1 0.5
0.3911 1 1
0.0554 0.5 0.5
1.0045 0.4871 0.4871
0.083 1 0.5
0.4072 0.9977 1
0.0627 1 1
0.1356 0.6867 1
0.5984 1 0.5
0.0221 0.9859 1
1.0649 1 1
0.0648 0.5 0.5
0.3813 1 1
0.7565 0.9187 1
1.2916 1 1
0.0208 1 0.5
0.2713 1 1
0.1944 0.5601 1
0.1817 0.7894 1
0.2128 0.5 0.5
0.3372 0.3644 0.4231
0.0415 0.5 0.5
0.095 0.5137 0.6987
0.0415 0.5 0.5
0.0676 0.3847 1
0.0415 0.4599 0.5
0.0806 0.3282 0.5
0.0388 0.7293 1
0.0841 1 1
0.1213 0.2816 1
0.0492 1 0.5
0.3161 1 1
0.0676 0.3847 1
0.1844 0.2799 0.5
0.0287 0.3342 0.5
0.3327 0.2772 0.3138
0.3671 1 1
0.0468 1 1
2.0135 0.9497 1
0.2343 1 1
0.0728 0.281 0.3905
0.0475 0.4577 0.7005
0.4366 0.411 1
1.7676 1 1
0.0235 0.5 0.5
0.2525 1 1
0.017 0.3765 0.5
0.0415 0.2779 1
0.0415 1 1
0.0515 0.3757 0.5
0.0415 0.5 0.5
1.2916 1 1
0.8371 0.7717 1
0.0184 1 0.5
0.0415 0.5 0.5
1.6009 1 1
0.2656 1 1
0.0152 0.3579 1
0.0284 0.3456 1
0.1667 0.4981 1
0.0224 0.2547 1
0.0468 0.3845 1
0.1318 1 1
0.3168 1 1
0.0201 0.4618 1
0.1004 0.2841 0
1.326 1 1
0.2293 1 1
0.3883 1 1
0.1667 0.4981 1
0.0208 0.5 0.5
0.0136 1 0.5
0.2778 0.3816 1
0.0415 0.5 0.5
0.1265 1 1
0.1119 1 1
0.0484 0.9939 1
0.06 0.4105 1
0.1043 0.5 0.5
0.35 1 1
0.4322 1 0.5
1.1312 1 1
2.2986 0.7708 1
0.9067 1 1
0.1705 1 1
0.1065 1 1
2.1995 0.6083 0.8155
0.0208 1 0.5
0.4813 0.268 1
0.4518 0.5592 1
0.0524 1 0.5
1.457 0.3108 1
0.0359 1 1
0.0609 0.2755 1
1.6336 1 1
2.9508 1 1
0.0242 0.9941 1
0.5895 1 1
0.0456 0.9923 1
0.3683 1 1
0.6191 1 1
0.7656 1 1
2.6016 1 1
0.3998 1 1
0.0573 0.2947 1
0.0403 0.3573 1
0.0359 0.3537 0.6534
0.0583 0.7327 1
0.6743 1 1
0.4232 0.4834 1
0.1429 1 1
0.0171 0.2967 1
0.7961 0.8001 1
0.0208 0.2716 1
0.4141 1 1
0.0442 0.5549 1
0.0468 1 1
0.0855 0.2983 0.5834
0.0433 0.3309 1
0.5723 0.7226 1
0.0507 0.3558 1
0.0229 0.2735 0.3908
0.0388 0.4662 1
0.3514 1 1
0.0848 1 1
0.0332 0.3154 1
0.4813 0.268 1
1.8446 1 1
0.1718 1 1
0.0237 1 0.5
1.3555 1 1
0.0468 1 1
1.6557 1 1
0.065 1 1
0.017 0.7077 1
0.1526 1 1
0.1553 0.6314 1
1.0229 0.4133 1
0.1844 0.2799 0.5
0.2336 0.9333 1
0.1771 0.6824 1
0.1109 1 0.5
0.5815 0.7953 1
0.2201 1 0.5
0.1019 0.4569 1
0.1522 0.6263 1
0.0645 1 1
0.0495 0.5486 1
0.0648 1 1
0.5613 0.6614 0.9009
0.1243 1 1
0.6478 1 1
0.06 0.991 1
0.1814 1 1
0.0468 1 1
0.4723 1 1
0.0679 0.2898 1
1.5016 1 1
0.0265 0.2995 1
0.3927 1 1
0.7583 1 1
0.5271 0.457 0.4883
1.6956 1 1
0.84661 0.525889 1
0.2541 0.4826 1
0.0583 0.2859 1
0.127 1 1
0.3041 1 1
0.197 0.512 1
0.0353 0.8896 1
0.2969 0.5219 0.5614
0.0415 0.5 0.5
0.1452 1 1
0.5216 0.6654 0.8986
1.1642 1 1
0.0676 1 1
0.11 1 1
0.0359 0.3537 0.6534
0.2709 0.318 0.3179
0.1162 0.4502 1
0.3683 1 1
1.1087 1 1
0.0182 0.2552 1
0.3513 1 1
0.1126 1 1
0.0423 0.3261 0.5695
0.0702 0.4586 0.5
0.0789 0.4659 1
0.4458 0.5971 1
0.0786 0.5 0.5
0.0179 1 0.5
0.377 1 1
0.2847 1 1
0.0439 0.6084 1
2.0655 1 1
0.1109 1 1
0.6122 1 1
0.1935 1 1
0.9785 1 1
1.2102 1 1
1.3429 1 1
2.0458 1 1
0.2948 1 1
0.6297 0.9295 1
0.0415 0.5 0.5
0.2943 1 1
0.0623 0.7611 0.9729
1.9595 1 1
0.0415 1 1
0.0162 0.4171 0
0.3661 0.7004 1
0.0733 0.7616 1
0.0238 0.9883 1
0.7064 1 1
0.8325 1 1
0.0677 0.5 0.5
0.1007 0.2939 1
0.0472 0.2809 0.3439
0.0468 1 1
1.8897 1 1
0.1432 1 1
0.1598 0.5438 0.7499
0.0468 1 1
1.3356 1 1
0.6343 1 1
0.5254 1 1
0.0344 0.4035 0.8726
0.0949 0.6806 1
0.1095 0.7406 1
0.2012 1 1
0.1005 1 1
0.888 1 1
0.0554 1 1
0.0553 0.5213 0.5
0.0443 0.9983 1
0.2037 1 1
0.8872 1 1
0.5404 1 1
3.4179 0.7052 1
1.2916 1 1
1.6898 1 1
0.4874 0.2983 1
1.6467 1 1
0.3469 1 1
8.0629 1 1
0.0468 0.2768 0.276
1.0876 1 1
0.0372 0.5 0.5
0.0623 0.4494 0.5
0.4458 0.5971 1
0.0148 0.4195 1
0.2056 1 1
0.3454 1 1
0.1978 1 1
0.0277 0.6172 1
0.0539 1 0.5
2.0508 1 1
0.0217 0.9936 1
0.026 0.9883 1
0.5851 1 0.5
0.0623 0.3641 1
1.1682 1 1
0.1192 1 1
0.5307 1 1
0.4231 1 1
1.1638 0.6457 1
0.1978 1 1
0.0516 0.3612 1
0.1247 1 1
0.026048 0.276387 0.303636
0.2849 1 1
0.0445 0.289 0.6082
0.0774 1 1
0.0497 0.261 1
2.2986 0.7708 1
1.8412 1 1
0.0623 0.4494 0.5
0.1931 1 1
0.8 1 1
0.0211 0.9883 1
0.0737 0.2854 0
0.0265 0.2995 1
0.1522 1 1
0.4575 0.5989 1
0.1143 0.3756 0.5
0.0676 0.8587 1
0.0676 1 1
0.22 1 1
0.0415 0.4982 1
0.0071 1 0.5
0.1935 0.4158 1
0.4619 1 1
0.0784 1 1
0.0178 0.2635 0.7302
0.0468 1 1
0.2509 1 1
1.7762 1 1
0.2899 0.3946 1
1.0229 0.4133 1
0.0504 0.9664 1
0.2008 0.707 1
0.7978 0.7118 0.9841
0.7003 1 1
0.0969 1 1
0.0287 0.3448 1
0.1143 1 1
0.0415 0.5 0.5
1.8528 1 1
0.1361 1 1
0.047 0.3092 0.3709
0.3137 0.4293 0.5656
0.4962 1 1
0.2751 1 0.5
0.1908 1 1
0.0605 0.5037 0.5027
0.0753 0.2985 1
0.0208 1 0.5
0.23 1 1
1.392 1 1
0.0371 0.5 0.5
2.1117 1 1
0.0221 0.9939 1
0.5162 1 1
0.234 1 1
0.5051 0.514 0.6486
0.2216 0.867 1
0.313 0.8814 1
0.1194 0.3552 1
0.0676 1 1
0.3561 1 1
0.0344 0.4035 0.8726
0.0504 1 1
1.1842 0.3077 1
0.0468 0.5451 1
0.3441 1 1
0.0539 1 0.5
0.0178 1 0.5
0.4575 0.5989 1
1.4185 1 1
2.6482 1 1
0.0374 0.4663 1
0.6432 1 1
0.0352 0.6449 1
0.661 1 1
0.2741 1 1
0.1716 1 1
0.1662 0.3346 1
0.0236 0.9883 1
0.1 0.557 1
0.5292 1 1
0.0415 0.5202 1
0.0415 0.5 0.5
0.014 0.2843 0.4014
0.0345 0.7056 1
0.3075 0.8126 1
0.1882 1 1
0.0517 1 0.5
0.0132 0.3711 0.6813
0.0492 0.4652 1
1.0549 1 1
0.039 0.3922 1
0.1886 0.7726 1
0.0208 0.2551 0.5
0.069 1 0.5
0.0403 1 1
0.252 1 1
0.4627 1 1
1.9117 0.9134 1
0.8425 1 1
0.0415 1 0.5
0.3556 0.512 0.6493
0.083 0.3233 0.8961
0.0415 1 0.5
0.5737 1 1
0.7876 1 1
0.0208 0.5 0.5
1.3995 1 1
0.5271 0.457 0.4883
0.5217 0.5 0.5
0.1679 1 1
0.38 1 1
0.043 0.2618 0.7394
0.0415 0.5 0.5
0.0226 0.9883 1
0.1 0.557 1
0.0445 0.3418 0.4186
0.038 0.3937 0.9847
0.0287 0.3524 1
0.0404 0.8256 1
1.4106 1 1
0.0145 0.2962 1
1.7834 1 1
0.9174 1 1
1.636 0.5376 1
0.6831 1 1
0.5756 0.4244 0.5098
1.0229 0.4133 1
1.9629 1 1
0.0249 0.9923 1
0.7689 0.837 1
0.381 1 1
0.0408 0.2815 0.3982
0.1451 1 1
0.0394 1 0.5
0.0208 1 0.5
0.068 1 0.5
0.1532 1 1
2.7821 1 1
0.0676 1 1
0.0573 0.5338 0.846
0.0676 1 1
0.2932 1 0.5
1.9147 1 1
0.0174 0.908 0
0.8219 1 1
0.1927 1 1
0.4303 0.5 0.5
2.8665 1 1
0.6026 0.2546 1
0.0287 1 1
0.4961 1 1
0.0531 0.5 0.5
1.2115 1 1
0.034 0.5498 0.5
1.4749 1 1
1.7843 1 1
0.3631 0.2532 0.8795
0.0856 0.4495 1
0.1053 0.8771 1
0.1734 1 0.5
0.1325 0.4057 1
0.0567 0.2728 1
0.0473 0.2791 0.3723
2.2986 0.7708 1
0.026 0.3066 0.7198
0.3117 0.3669 1
0.4373 1 0.5
1.8528 1 1
1.0795 0.5153 1
1.6545 1 1
0.0371 0.5 0.5
0.026 0.3148 1
0.3631 0.2532 0.8795
1.8528 1 1
1.2916 1 1
0.3413 1 1
0.0573 1 1
1.7529 1 1
1.0435 0.3897 1
0.073 1 1
0.1016 0.3344 1
0.1376 0.6522 1
0.0676 0.8076 1
0.1785 1 1
0.6115 0.7786 1
0.5899 0.6422 1
0.0495 0.7161 1
0.0793 1 0.5
0.0445 0.3443 0.4223
1.4106 1 1
0.8036 1 1
0.0356 1 1
0.1553 0.6314 1
2.4101 1 1
0.0171 0.5532 0.7004
0.2849 1 1
0.0724 1 0.5
0.2033 1 1
0.0415 1 1
0.888 1 1
0.0468 0.3061 1
0.0208 0.8452 1
0.0742 0.3941 0.7343
0.0885 1 1
0.0359 0.3537 0.6534
0.0899 0.9841 1
2.0368 1 1
0.0184 0.4529 0.5
0.065 0.5 0.5
0.1704 1 1
1.5552 0.322 1
0.8324 1 1
0.213 1 1
0.6935 1 1
2.2986 0.7708 1
2.0458 1 1
0.0468 1 1
1.0186 1 1
0.9308 1 1
0.1251 0.6094 1
0.3171 0.2681 0.9202
2.6482 1 1
1.1225 1 1
0.042 0.4428 0.604
0.2462 1 0.5
0.0468 0.5161 1
0.0676 0.3598 1
0.0167 1 0.5
0.026 0.2522 1
0.0415 1 1
0.0223 0.6866 1
2.2986 0.7708 1
0.0623 0.379 1
0.0337 0.4269 1
0.0396 0.5137 0.5508
0.0968 0.2878 0.86
0.5162 1 1
0.1579 1 1
0.0469 0.3425 0.3547
0.0468 1 1
0.0415 0.5 0.5
0.2208 0.541 0.4549
2.1134 0.6069 0.6069
1.5911 1 1
0.439 1 1
0.0676 1 1
0.0177 0.6357 1
0.0623 0.6338 1
0.5541 0.7153 0.9911
0.0831 1 1
0.0529 1 1
0.4823 1 1
0.1384 1 1
0.417 1 1
0.3186 1 1
1.1768 1 1
0.0715 1 1
2.3413 0.5646 0.739
0.0166 0.3818 1
0.5648 1 1
0.1051 0.2786 0.6471
1.6176 1 1
0.0926 0.278 1
0.352 1 1
0.0836 0.8504 1
0.1138 0.4931 1
2.1174 1 1
0.0346 0.7211 0.5
0.7447 0.8023 1
0.018 0.3805 1
0.2585 1 1
0.0802 1 1
0.7853 1 1
0.4868 1 0.5
0.0974 1 1
0.1866 1 1
0.0209 0.9883 1
0.9877 1 1
0.0215 0.2713 0
0.0605 0.5037 0.5027
1.5904 1 1
1.3007 1 1
2.6216 1 1
0.0433 0.3309 1
0.7656 1 1
0.0359 0.2791 1
0.2016 1 1
0.0468 1 1
0.0848 1 1
0.421 0.6088 0.6087
0.3786 0.3026 0.3453
0.3246 1 1
0.0991 0.3584 0.5
0.3308 1 1
0.1265 1 0.5
0.1296 0.9544 1
0.4394 1 1
0.0963 0.4277 1
1.1659 0.8785 1
0.2676 1 1
0.0415 1 0.5
0.0531 1 1
0.2491 1 0.5
0.034 0.4204 0.002
0.0341 1 0.5
0.4538 1 1
0.2576 1 0.5
0.5831 1 1
0.4336 0.4357 0.5651
2.6016 1 1
0.3321 1 0.5
0.1296 0.9544 1
0.1356 0.6867 1
0.058 0.6655 1
0.0676 1 1
0.8821 1 1
0.0354 0.3532 1
0.2608 0.4099 1
0.0266 0.2728 0.3655
0.026 0.3201 1
0.8806 0.4171 1
0.0318 0.3207 1
0.2539 1 1
0.25 1 1
0.9253 0.9526 1
2.1651 1 1
0.0997 1 1
1.4215 1 1
18.4858 0.3343 1
0.0442 0.2825 0.3348
0.6008 1 1
0.0403 0.3573 1
0.1931 1 1
0.0835 0.2983 0.3367
0.0369 0.4028 0.5
0.0346 0.7211 0.5
0.1188 1 1
0.0738 1 0.5
0.0415 0.5 0.5
0.0399 1 0.5
0.8219 1 1
1.0688 1 1
0.047 0.2545 0.3626
1.7305 1 1
0.0429 1 1
0.7407 1 1
0.6924 1 1
0.0447 0.3897 0.4953
0.0894 0.9911 1
0.0073 0.2587 0
0.2438 0.8556 1
0.1069 1 1
0.2085 0.5294 1
0.2319 1 1
0.9308 1 1
0.0776 0.5 0.5
0.4937 1 1
0.1183 0.6258 1
0.107 0.8727 1
1.3506 1 1
0.0415 0.5 0.5
0.0384 0.2546 0.8096
0.0415 0.5 0.5
0.4172 1 1
0.5602 1 1
0.2238 1 1
1.0045 0.4871 0.4871
0.5779 1 1
1.2269 1 1
0.0393 1 0.5
0.0417 0.4755 0.3468
0.1427 1 1
0.0079 0.4323 0.5
0.1843 0.443 1
0.0814 1 1
0.0301 0.5 0.5
0.1192 0.2887 1
0.0989 1 1
0.0208 0.9811 1
0.56 1 1
0.034 0.5868 0.5
0.0404 1 0.5
0.0379 1 1
0.0415 1 1
0.0963 1 1
0.0676 0.4746 0.5091
0.0208 0.2861 0.4267
1.9307 1 1
1.2103 1 1
0.0361783 0.327425 0.645758
1.3016 1 1
0.0676 0.8166 1
0.8179 1 1
2.0238 1 1
0.0377 0.2895 1
0.1534 1 1
0.2296 1 1
0.056 0.5 0.5
0.1316 0.8331 1
1.655 1 1
0.1858 1 1
0.1046 0.6835 1
0.0183 0.5 0.5
0.1732 0.9428 1
0.0895 1 1
1.7966 0.3454 1
0.0997 1 1
0.1228 1 1
0.0415 0.3707 0.5
0.3706 1 1
0.1701 1 0.5
0.3371 1 1
0.0879 1 1
0.7417 1 1
0.0589 0.737 0.5
1.2916 1 1
0.0796 0.7565 1
0.786 1 1
0.3798 0.4933 1
0.083 1 0.5
0.0415 0.8559 1
0.2108 1 1
0.5588 1 1
0.159303 0.26208 1
0.0345 1 0.5
0.0304 0.3207 1
1.457 0.3108 1
0.4366 0.411 1
0.1041 1 1
0.2336 0.9333 1
0.0462 0.3495 0.4248
2.0705 1 1
0.0415 1 0.5
0.7194 1 1
4.0774 0.5213 1
0.0343 0.5876 0.5
0.1051 1 0.5
0.0415 0.2857 0.5049
0.0396 0.5137 0.5508
1.0876 1 1
0.8801 1 1
0.7657 1 1
5.2069 1 1
0.0468 0.2791 0.6546
0.0485 0.3074 0.3469
0.9062 1 1
0.0167 0.4872 0.7938
0.9958 1 1
0.442 0.5545 0.7162
0.0415 1 0.5
0.6567 1 1
0.0167 1 0.5
0.0208 0.3027 0.3375
0.0703 1 0.5
0.3035 1 1
0.026 0.2888 0.3271
0.1716 0.3691 0.425
0.6747 1 1
0.0676 1 1
0.0963 1 1
0.2518 1 1
0.2758 1 1
0.0385 0.4701 1
0.7302 1 1
0.0406 0.4733 0.5301
0.0208 1 1
0.0609 0.2755 1
0.0415 0.5 0.5
0.5774 1 1
0.083 0.2718 0.5
0.0846 0.3456 1
0.0468 1 1
0.5789 1 1
0.0202 0.2763 1
0.0676 1 0.5
0.2395 1 1
1.4106 1 1
0.0468 0.3051 1
0.184 1 0.5
0.0342 0.3409 1
0.1533 0.6061 1
0.2438 0.8556 1
0.1229 1 1
0.0429 0.7317 1
0.0415 0.5 0.5
0.0868 1 0.5
0.381 1 1
1.457 0.3108 1
0.0676 0.4094 1
0.0175 0.3672 1
0.1798 0.2643 1
2.0545 1 1
0.1194 0.3552 1
0.0676 0.71 1
0.0208 0.2885 1
0.0342 0.3698 0.6099
0.6926 1 1
0.1596 1 1
0.4211 1 1
1.2956 1 1
0.0415 0.5096 1
0.0208 1 1
0.0783 0.3174 0.5
0.0239 0.9883 1
0.2471 1 1
0.0415 1 1
0.0415 0.5 0.5
0.2303 1 1
0.034 0.3843 1
1.5911 1 1
0.0546 0.4083 0.6112
0.0468 0.2802 0.5748
0.5899 0.6422 1
0.0166 0.4103 1
0.0767 0.411 0.4101
2.6016 1 1
1.6783 1 1
0.0755 0.3411 1
0.0533 0.299 1
0.1493 1 0.5
1.9117 0.9134 1
0.515 0.9105 1
1.0229 0.4133 1
1.5016 1 1
0.2616 0.738 1
0.0354 0.5817 0.5
0.1065 1 0.5
0.0478 0.4479 1
1.6155 0.9237 1
0.0676 1 1
0.1771 0.6557 1
1.0155 1 1
0.0403 0.3573 1
1.2916 1 1
0.1579 1 1
1.0795 0.5153 1
0.0182 1 0.5
0.1065 1 0.5
0.0714 1 0.5
0.0177 0.6418 0.5
0.056 1 1
2.5454 1 1
0.0755 0.3604 1
2.9508 1 1
0.1992 0.7192 1
0.1982 0.7901 1
0.109 0.674 1
0.1095 0.7406 1
0.0415 1 1
0.0364 0.5 0.5
0.0187 1 1
0.0276 0.2571 0
0.0208 0.4198 0.5
0.0089 0.2502 0.2822
0.4906 1 1
1.3007 1 1
0.055 0.576 1
0.0375 0.4411 1
0.0283 0.276 0.3916
0.7873 1 1
0.23 1 1
1.6155 0.9237 1
0.026 0.9883 1
0.0883191 0.28756 0.824023
1.5309 1 1
0.0208 0.2861 0.4267
1.2103 1 1
0.0143 0.9621 1
0.9403 1 1
0.0287 0.3295 0.3581
0.0256 1 0.5
0.1392 1 1
0.2033 1 1
0.8421 1 1
0.1473 0.5 0.5
1.8316 0.6397 1
2.0368 1 1
0.5723 0.7226 1
0.1536 1 1
0.2997 1 1
0.082 1 0.5
0.0657 1 0.5
0.0697 1 1
0.0342 0.3698 0.6099
1.3356 1 1
0.3102 1 1
0.0939 0.5 0.5
0.1119 1 1
0.0308 0.9949 1
0.0299 1 1
0.0335 0.2767 0.3792
0.7545 1 1
0.3301 1 1
0.0554 0.3877 1
1.9452 0.964 1
0.0631 0.3022 0.5
0.6478 1 1
0.0468 1 1
0.039 0.3372 0.8019
0.294 0.6251 1
0.0816 1 1
0.0423 0.9838 1
0.0601 0.4108 1
1.0229 0.4133 1
0.4844 1 1
0.0349 1 0.5
0.0645 0.6989 1
0.8035 1 1
0.0208 0.2734 0.8409
0.0477 0.7664 1
0.0468 0.3061 1
0.0531 0.3893 0.534
0.0963 1 1
0.0208 0.5 0.5
0.1013 1 0.5
0.1281 1 1
0.0468 0.3051 1
0.1481 1 0.5
0.1456 1 1
0.1329 1 1
0.3054 1 1
0.04 0.4673 1
0.0676 0.9505 1
0.0366 1 1
0.6853 1 1
0.0242 0.2759 0.3914
1.15056 0.565389 1
0.3492 1 1
0.055 0.576 1
0.0883 1 1
1.2934 1 1
0.0963 1 1
0.1109 1 1
0.0396 1 1
0.0468 1 1
0.0748 0.6966 1
0.0369 0.5 0.5
0.9314 1 1
1.7047 1 1
0.4949 1 1
1.8528 1 1
2.5454 1 1
2.0791 1 1
0.1075 1 0.5
0.039 0.3849 1
0.0417 0.4685 1
0.0216 0.9923 1
0.1461 0.9537 1
0.0208 1 0.5
1.3429 1 1
0.0468 1 1
0.0415 0.8559 1
0.54 1 1
1.3564 1 1
0.0208 0.4998 1
0.0384 0.2546 0.8096
0.4874 0.2983 1
0.0863824 1 0.5
0.0257 0.5874 1
0.083 0.6181 1
0.0392 1 1
0.0415 0.2555 1
0.0302 0.2776 0.3912
0.0676 1 1
0.0156 0.5781 0.5751
0.5982 1 1
1.2749 1 1
0.2725 1 0.5
0.0208 1 0.5
0.335 1 1
0.0144 0.252 0
0.0571 1 1
0.4665 0.7117 0.9862
0.1109 1 1
0.1541 1 1
0.0376 0.3221 1
0.0798742 0.287081 1
0.0275 0.5145 1
0.0676 1 1
0.5564 0.3616 1
0.0453 0.3925 0.4978
0.1072 1 1
0.1552 0.5097 1
0.3918 0.4292 0.1567
0.0216 0.3899 1
0.0415 0.3783 1
0.0756 1 0.5
0.0379 1 1
0.8712 1 1
0.0079 0.5 0.5
0.5397 0.8227 1
0.1259 1 1
0.3442 1 1
0.0846 0.5264 1
0.0677 0.5 0.5
0.0415 0.5 0.5
0.0616 1 1
0.0495 0.9566 0.9502
0.4405 1 1
0.0305 1 0.5
0.0332261 0.400572 0.5
1.6267 1 1
0.1228 1 1
0.1549 1 1
0.422 1 1
0.0093 0.28 0.3786
0.0691 0.5 0.5
0.506 1 1
0.0542 1 0.5
0.0643 0.2619 0.4641
0.1096 1 1
0.2208 0.541 0.4549
1.0155 1 1
1.5123 1 1
0.0734 1 0.5
0.6579 1 1
0.0468 1 1
0.216 1 1
0.2997 1 1
0.4786 1