Detailed view for EgrG_000257850

Basic information

TDR Targets ID: 586863
Echinococcus granulosus, fch and double sh3 domains protein 2
Source Database / ID:  GeneDB

pI: 7.0175 | Length (AA): 944 | MW (Da): 104089 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00018   SH3 domain
PF00611   Fes/CIP4, and EFC/F-BAR homology domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 423 5i6r (A) 17 477 20.00 0 1 0.517493 0.71
15 227 2efk (A) 10 219 15.00 0.017 0.06 0.317636 -0.01
19 347 4dyl (A) 16 340 25.00 0.0056 0.41 0.293117 1.17
579 632 2a36 (A) 2 55 31.00 0.047 0.81 0.389803 0.49
652 761 1udl (A) 5 93 35.00 0 1 0.255925 0
658 759 1i1j (A) 2 89 19.00 0 0.19 0.130451 -0.44
689 758 2dl7 (A) 10 67 50.00 0.00015 0.77 0.436753 0.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132528)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0274805   SH3 domain-containing protein
Drosophila melanogaster Dmel_CG43479   nervous wreck
Echinococcus granulosus EgrG_000257910   Mediator of RNA polymerase II transcription
Echinococcus granulosus EgrG_000257850   fch and double sh3 domains protein 2
Echinococcus multilocularis EmuJ_000257850   fch and double sh3 domains protein 2
Echinococcus multilocularis EmuJ_000257910   mediator of RNA polymerase II
Homo sapiens ENSG00000137478   FCH and double SH3 domains 2
Mus musculus ENSMUSG00000030691   FCH and double SH3 domains 2
Schistosoma japonicum Sjp_0081130   Mediator of RNA polymerase II transcription subunit 27, putative
Schistosoma japonicum Sjp_0091090   FCH and double SH3 domains protein 2, putative
Schistosoma mansoni Smp_146550   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0065 0.3464 0.3464
0.0039 0.2713 0.0459
0.0059 0.3 0.3
0.0075 0.2576 0.0617
0.0137 0.2846 0.2741
0.0048 0.281 0.281
0.0282 0.283 0.283
0.0029 0.4037 0.4037
0.0282 0.283 0.283
0.0068 0.2794 0.2794
0.0029 0.4037 0.4037
0.0048 0.3625 0.3565
0.0065 0.3464 0.3464
0.0027 0.3179 0.2899
0.00394418 0.278418 0.262031
0.0039 0.2713 0.0459
0.0027 0.3179 0.2899
0.0336199 0.276589 0.265254
0.0322685 0.273741 0.262341
0.0064 0.3347 0.3347
0.0351989 0.270507 0.26116
0.0061 1 1
0.00394418 0.278418 0.262031
0.0137 0.3036 0.3036
0.0378 0.315 0.315

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000257850 (Echinococcus granulosus), fch and double sh3 domains protein 2
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