Detailed view for EgrG_000895000

Basic information

TDR Targets ID: 586956
Echinococcus granulosus, bromodomain adjacent to zinc finger domain

Source Database / ID:  GeneDB

pI: 6.1479 | Length (AA): 2393 | MW (Da): 261353 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00439   Bromodomain
PF00628   PHD-finger
PF01429   Methyl-CpG binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005634   nucleus  
GO:0005515   protein binding  
GO:0003677   DNA binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
463 523 4lg7 (A) 83 143 30.00 0.029 0.53 0.386691 -0.44
579 1459 5f0n (A) 117 1016 12.00 0 0.81 0.348857 0.63
684 1221 2pft (A) 86 652 13.00 0 0.74 0.237522 0.37
710 839 5f0k (A) 325 468 26.00 0.13 0.3 0.363625 -0.57
884 1798 4zhj (B) 347 1327 15.00 0 0.97 0.235065 1.19
1136 1235 5hmo (A) 811 909 32.00 0.19 0.02 0.298089 -0.42
1803 1858 4qf3 (A) 1928 1983 66.00 0 1 0.755702 0.1
1807 1855 5vab (A) 23 71 47.00 0 0.97 0.510176 0.02
1808 1928 5erc (A) 275 396 31.00 0.011 0.7 0.0858641 1.07
2104 2217 4ybm (A) 884 998 44.00 0 1 0.649939 -1.2
2121 2225 4qc3 (A) 2065 2166 43.00 0 1 0.691578 -2.22
2122 2269 4n4f (A) 1091 1277 26.00 0 1 0.389547 -0.99
2132 2220 2r10 (A) 204 289 29.00 0 0.9 0.405892 -0.99

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131570)

Species Accession Gene Product
Brugia malayi Bm1_46290   Bromodomain containing protein
Caenorhabditis elegans CELE_ZK783.4   Protein FLT-1
Drosophila melanogaster Dmel_CG10897   toutatis
Echinococcus granulosus EgrG_000895000   bromodomain adjacent to zinc finger domain
Echinococcus multilocularis EmuJ_000895000   bromodomain adjacent to zinc finger domain
Homo sapiens ENSG00000076108   bromodomain adjacent to zinc finger domain, 2A
Homo sapiens ENSG00000226266   bromodomain adjacent to zinc finger domain, 2B
Loa Loa (eye worm) LOAG_12358   hypothetical protein
Loa Loa (eye worm) LOAG_13083   hypothetical protein
Loa Loa (eye worm) LOAG_13007   hypothetical protein
Loa Loa (eye worm) LOAG_05113   hypothetical protein
Mus musculus ENSMUSG00000026987   bromodomain adjacent to zinc finger domain, 2B
Mus musculus ENSMUSG00000040054   bromodomain adjacent to zinc finger domain, 2A
Schistosoma japonicum Sjp_0100460   Conserved hypothetical protein
Schistosoma japonicum Sjp_0030660   ko:K01549 ATP synthase [EC3.6.3.14], putative
Schistosoma japonicum Sjp_0030670   Cleft lip and palate transmembrane protein 1-like protein, putative
Schistosoma japonicum Sjp_0311230   expressed protein
Schistosoma japonicum Sjp_0100450   hypothetical protein
Schistosoma mansoni Smp_170760   bromodomain containing protein
Schmidtea mediterranea mk4.006357.00   Bromodomain adjacent to zinc finger domain protein 2B
Schmidtea mediterranea mk4.006357.01   Toutatis
Schmidtea mediterranea mk4.012321.00   Toutatis

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2A Compounds References
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0072 0.7332 1
0.0134 0.724 1
0.0063 0.4266 1
0.0072 0.7186 1
0.0064 0.7186 1
0.0247 0.5093 0.7185
0.0072 0.7332 1
0.0058 0.7332 1
0.0059 0.3086 0.2911
0.0128 0.2628 0.3539
0.0058 0.7437 0.9766
0.0072 0.724 1
0.0199 0.7554 0.9966
0.0186 0.2609 0.3855
0.0207 0.2563 0.2538
0.0072 0.2999 1
0.0067 0.4182 0.5729
0.0072 0.7332 1
0.0068 0.3116 0.3116
0.006 0.736 1
0.0668 0.5065 0.5065
0.0072 0.7395 1
0.0066 0.3263 0.3223
0.0072 0.7332 1
0.0202 0.3607 0.9617
0.0063 0.7437 0.9213
0.0061 0.7837 1
0.0119 0.266 0.2639
0.0073 0.7332 0.9182
0.0072 0.3652 0.3544
0.0067 0.4161 0.9775
0.0057 0.2634 1
0.0065 0.2587 0.2587
0.0072 0.3223 0.3223
0.0072 0.736 1
0.0072 0.7332 0.9752
0.0064 0.3917 0.6253
0.0072 0.724 0.9167
0.0068 0.724 1
0.0063 0.5219 0.5094
0.0072 0.2677 0.2677
0.006 0.4062 0.4447
0.0072 0.7332 1
0.0364 0.2866 0.2915
0.0071 0.3886 0.3555
0.018 0.3435 0.3424
0.0061 0.4483 0.7885
0.0072 0.736 1
0.0061 0.7332 1
0.0072 0.7487 1
0.0127 0.3575 0.3343
0.0329 0.2943 0.4271
0.0061 0.7186 0.7243
0.0072 0.3674 1
0.0072 0.2677 0.2677
0.0072 0.4071 0.4071
0.1501 0.6853 0.6844
0.0072 0.7437 1
0.0058 0.3939 0.3939
0.006 0.7374 1
0.0072 0.2743 0.2743
0.0371 0.5061 0.5061
0.1823 0.6548 0.7022
0.0259 0.4601 0.6767
0.0061 0.4168 0.928
0.0059 0.724 1
0.0059 0.2857 0.2857
0.0058 0.2652 0.2652
0.0072 0.291 1
0.0058 0.7332 1
0.02 0.2603 0.5271
0.0048 0.7332 1
0.0058 0.7382 0.8024
0.0072 0.7437 1
0.0058 0.6178 0.6178
0.0066 0.3366 0.3366
0.012 0.3614 0.3789
0.0061 0.305 0.3117
0.0072 0.736 0.8105
0.0583 0.2663 0.2656
0.0076 0.432 0.4624
0.0063 0.2868 0.2844
0.006 0.3312 0.3223
0.0064 0.7332 1
0.0072 0.3091 0.3091
0.0072 0.7332 0.9752
0.0059 0.2854 0.3223
0.0613 0.361 0.361
0.0072 0.7288 1
0.0072 0.724 0.8195
0.0072 0.2829 0.2962
0.0058 0.2625 0.2529
0.0065 0.7527 1
0.0065 0.4266 1
0.0064 0.3531 0.3531
0.0064 0.2799 0.2799
0.0189 0.4838 0.4818
0.0061 0.7332 1
0.0123 0.2775 0.2507
0.0072 0.2625 0.2529
0.0196 0.3183 0.4449
0.0071 0.736 1
0.0058 0.7332 0.9167
0.0072 0.3312 0.3288
0.0419 0.2994 0.6193
0.0072 0.736 1
0.0072 0.724 1
0.0065 0.7437 1
0.0072 0.5437 0.5437
0.0058 0.2524 0.2438
0.0064 0.3156 0.3584
0.0065 0.5058 0.4745
0.0063 0.3974 0.4113
0.0058 0.3223 0.3223
0.0059 0.2791 0.2735
0.0059 0.3561 0.3504
0.0072 0.724 0.9167
0.0065 0.4266 1
0.0065 0.724 1
0.0707 0.2662 0.4027
0.0184 0.3512 0.5227
0.006 0.611 0.611
0.0072 0.7437 1
0.007 0.4141 0.882
0.0072 0.724 1
0.0058 0.724 0.9167
0.0072 0.288 0.2858
0.0072 0.7332 1
0.0072 0.7332 0.9129
0.0069 0.6075 0.801
0.0059 0.7332 1
0.0063 0.3091 0.3091
0.0072 0.724 1
0.0388 0.7899 1
0.0065 0.3217 0.3041
0.0119 0.2521 0.2521
0.0069 0.4055 0.4248
0.0072 0.3191 0.3113
0.0059 0.5219 0.5094
0.0205 0.2826 0.3034
0.0064 0.736 0.9766
0.0058 0.2625 0.2529
0.0184 0.3097 1
0.0072 0.3835 1
0.0072 0.5286 0.5286
0.0061 0.6598 1
0.0059 0.4309 0.4309
0.0072 0.736 1
0.0067 0.6888 0.6888
0.0177 0.2558 0.2558
0.0072 0.736 1
0.0067 0.724 1
0.0072 0.2985 0.3981
0.0072 0.3263 0.3223
0.0072 0.3417 0.3417
0.0318 0.257 0.3858
0.0068 0.5894 1
0.0061 0.3191 0.3091
0.0063 0.2554 0.2553
0.0071 0.4053 0.4025
0.0072 0.2506 1
0.0072 0.2625 0.2529
0.0371 0.4022 0.4186
0.0065 0.3072 0.2923
0.0121 0.3253 0.3253
0.0058 0.3578 1
0.0058 0.724 0.9167
0.0063 0.4814 1
0.0059 0.3895 0.3895
0.006 0.2625 0.2529
0.0058 0.2594 0.2594
0.0198 0.3243 0.4288
0.0136 0.3459 0.5608
0.0072 0.5008 1
0.0072 0.7437 1
0.0059 0.724 0.9422
0.0072 0.3299 0.3299
0.0072 0.5402 0.5286
0.0127 0.5303 1
0.006 0.7332 1
0.0076 0.3111 0.3088
0.0205 0.2572 0.2572
0.0072 0.7186 1
0.0072 0.7332 0.9129
0.0072 0.4618 0.4549
0.044 0.3835 0.4729
0.0327 0.4284 0.4284
0.0066 0.6457 1
0.0205 0.4918 0.6734
0.0072 0.7487 1
0.0072 0.7186 1
0.0072 0.736 1
0.0063 0.736 1
0.0061 0.3485 0.8192
0.0194 0.3378 0.9881
0.0869 0.286 0.286
0.0059 0.724 1
0.0182 0.3486 0.4751
0.0128 0.3431 0.3294
0.006 0.5684 0.6191
0.0072 0.4141 1
0.0257 0.3031 0.3031
0.0062 0.2798 0.2798
0.0119 0.3327 0.5357
0.0067 0.2857 0.2857
0.0072 0.7437 1
0.0122 0.3588 0.3588
0.0072 0.7437 1
0.0063 0.4858 1
0.0068 0.4605 1
0.0066 0.2858 0.2858
0.0067 0.3633 0.3731
0.0068 0.6643 0.6509
0.012 0.2861 0.2861
0.0059 0.2587 0.2571
0.0061 0.4188 1
0.0853 0.3228 0.3228
0.0072 0.3246 1
0.0066 0.2677 0.2677
0.006 0.2858 0.2791
0.0072 0.7332 1
0.0058 0.3516 0.3516
0.0072 0.2677 0.2677
0.0058 0.2676 0.2676
0.0069 0.3091 0.3091
0.0058 0.724 1
0.0747 0.2553 0.255
0.0064 0.2625 0.2529
0.0072 0.3393 0.3393
0.0072 0.7233 1
0.0058 0.2862 0.4196
0.0072 0.4448 1
0.0072 0.724 1
0.0073 0.3939 0.4131
0.0064 0.3746 1
0.0061 0.2625 0.2529
0.0126 0.3295 0.3295
0.0072 0.3541 0.3516
0.0062 0.736 0.9213
0.0123 0.4701 1
0.0072 0.7186 1
0.0076 0.2742 0.2742
0.0123 0.3306 0.3259
0.006 0.2648 0.2551
0.0072 0.724 0.9167
0.0053 0.3506 1
0.0072 0.724 1
0.0072 0.7332 0.9752
0.0952 0.5234 0.5232
0.0072 0.2813 0.2798
0.0072 0.2985 0.2985
0.0058 0.2625 0.2529
0.0072 0.7332 1
0.0076 0.3547 0.3731
0.007 0.2625 0.2529
0.0066 0.4368 0.5807
0.0562 0.253 0.2528
0.0072 0.724 1
0.0072 0.736 1
0.0058 0.736 1
0.0058 0.724 0.9752
0.0059 0.7637 0.8734
0.0059 0.7437 1
0.0059 0.2625 0.2529
0.0069 0.3502 0.3502
0.0059 0.2798 0.2798
0.0072 0.3329 0.3226
0.0072 0.6027 0.8116
0.0072 0.2664 0.2664
0.0062 0.2625 0.2529
0.0063 0.2882 0.2991
0.0061 0.7332 1
0.0072 0.2625 0.2529
0.0126 0.2623 0.2615
0.0072 0.724 0.9751
0.0072 0.7474 1
0.0134 0.3566 0.3488
0.012 0.4783 0.6189
0.006 0.2769 0.2677
0.0067 0.3914 0.9766
0.0072 0.2625 0.2529
0.0072 0.2677 0.2677
0.0064 0.7374 1
0.006 0.3026 0.3026
0.0066 0.2626 0.2626
0.0185 0.2594 0.2584
0.0252 0.3028 0.3063
0.0072 0.3628 0.3628
0.0064 0.3898 0.3898
0.0058 0.2617 0.2617
0.0712 0.3711 0.3708
0.0059 0.7437 1
0.0072 0.332 0.321
0.0072 0.724 1
0.006 0.5261 0.5261
0.0124 0.4286 1
0.0125 0.2551 0.2489
0.0247 0.3265 0.4458
0.0072 0.5069 0.5069
0.0061 0.736 1
0.0072 0.7332 1
0.0058 0.2601 0.2505
0.0065 0.3223 0.3223
0.0072 0.7186 1
0.0072 0.4062 1
0.0121 0.3146 0.4899
0.0072 0.2798 0.2798
0.0072 0.7332 1
0.0495 0.3315 0.3436
0.0134 0.3789 0.3712
0.0052 0.2625 0.2529
0.0061 0.736 1
0.0059 0.2625 0.2529
0.0129 0.4706 0.6652
0.0059 0.736 1
0.0063 0.3091 0.3091
0.0072 0.736 0.9766
0.013 0.4275 1
0.0063 0.7374 1
0.0072 0.2625 0.2529
0.0063 0.2882 0.2991
0.0061 0.6786 0.6676
0.0058 0.2687 0.2858
0.0072 0.3189 1
0.0072 0.7186 0.9107
0.0072 0.4015 0.3895
0.0072 0.4266 1
0.0066 0.2595 0.25
0.0072 0.7084 1
0.0059 0.2725 0.2646
0.0125 0.3701 0.835
0.0128 0.2883 0.2883
0.0059 0.2769 0.2677
0.0072 0.2625 0.2529
0.006 0.2625 0.2529
0.0072 0.2658 0.4505
0.0072 0.724 1
0.0072 0.724 1
0.0063 0.3226 0.3226
0.0072 0.266 0.2798
0.0185 0.3597 0.4918
0.006 0.2763 0.2763
0.0062 0.7332 1
0.0056 0.7437 0.8116
0.0061 0.2952 0.2952
0.0063 0.2565 0.2471
0.0072 0.736 1
0.0061 0.2804 0.2798
0.006 0.724 0.9752
0.0072 0.724 1
0.0072 0.7186 0.9107
0.0445 0.4721 0.9593
0.0062 0.7332 1
0.0064 0.322 0.3935
0.0976 0.5779 0.5891
0.0072 0.7417 1
0.0066 0.736 0.9766
0.0059 0.28 0.276
0.0067 0.2509 0.269
0.0072 0.3005 0.3005
0.0072 0.724 1
0.0118 0.4346 0.617
0.0061 0.7374 1
0.0169 0.2887 0.4581
0.0133 0.3308 0.3308
0.0072 0.4044 0.5752
0.0061 0.7332 1
0.0265 0.3432 0.683
0.0072 0.724 0.9752
0.0069 0.736 1
0.0138 0.2657 0.2657
0.0072 0.736 1
0.0059 0.3879 1
0.0118 0.2709 0.2709
0.0072 0.4168 1
0.0072 0.724 1
0.0386 0.4904 0.4903
0.0072 0.724 1
0.0072 0.7332 1
0.0072 0.7332 1
0.0058 0.6863 0.6762
0.0072 0.2625 0.2529
0.0069 0.7437 0.9213
0.0058 0.72 0.6974
0.0138 0.3083 1
0.0059 0.736 0.9766
0.0072 0.724 0.801
0.0119 0.3207 0.3198
0.0863 0.3017 0.3017
0.0072 0.724 1
0.0072 0.7332 1
0.0072 0.724 0.9752
0.0072 0.485 0.4804
0.0058 0.2677 0.2587
0.0062 0.4268 1
0.0067 0.4748 1
0.0061 0.2905 0.2905
0.0072 0.4132 0.5286
0.0072 0.736 1
0.0058 0.5219 0.5094
0.0072 0.736 1
0.0062 0.7186 0.9107
0.0719 0.3716 0.3716
0.0072 0.7332 1
0.0076 0.287 0.287
0.0055 0.3991 0.9167
0.007 0.2677 0.2677
0.0121 0.3608 0.4716
0.0058 0.724 0.9167
0.0072 0.724 1
0.0058 0.7332 1
0.0072 0.7437 1
0.03 0.3162 0.3219
0.0059 0.4188 1
0.0072 0.724 1
0.0072 0.7437 1
0.0059 0.7332 1
0.0074 0.5852 0.5708
0.0658 0.3553 0.3546
0.0424 0.2879 0.2876
0.0063 0.724 1
0.0072 0.3091 0.3091
0.0181 0.2529 0.2502
0.0072 0.724 1
0.0072 0.2577 0.352
0.0063 0.7453 0.9777
0.006 0.2647 0.2647
0.0062 0.4623 1
0.0074 0.2984 1
0.0068 0.2857 0.2857
0.0289 0.2545 0.3908
0.006 0.3327 0.3036
0.0072 0.2677 0.2677
0.0132 0.2933 0.3609
0.0062 0.2625 0.2529
0.0065 0.7374 1
0.0072 0.2625 0.2529
0.0306 0.3528 0.5493
0.0122 0.3413 0.5789
0.014 0.4863 0.6428
0.0064 0.2811 0.2811
0.0072 0.7332 1
0.006 0.724 1
0.0072 0.2994 0.338
0.0072 0.7332 1
0.0064 0.3186 0.3099
0.0072 0.3478 0.3365
0.0068 0.7437 0.8224
0.0072 0.7186 1
0.0069 0.504 0.9752
0.0062 0.3632 0.3632
0.0061 0.2803 0.8083
0.0059 0.7186 1
0.007 0.7437 0.9084
0.0598 0.2815 0.281
0.0072 0.724 1
0.0058 0.264 0.2563
0.0545 0.3198 0.3572
0.0122 0.3151 0.4936
0.0119 0.2577 0.3363
0.0121 0.2622 0.2622
0.0122 0.2916 0.2916
0.0065 0.3875 0.378
0.0383 0.3902 1
0.0059 0.724 1
0.0125 0.3565 0.3525
0.0072 0.3278 0.3169
0.0072 0.724 0.801
0.0707 0.2662 0.4027
0.1881 0.6515 0.7716
0.0058 0.6354 0.6354
0.0842 0.2682 0.2682
0.0067 0.2789 1
0.0072 0.2625 0.2529
0.0062 0.7374 1
0.0244 0.264 0.2638
0.0258 0.3501 0.5445
0.0115 0.3168 0.3081
0.0072 0.7186 1
0.0074 0.7819 1
0.0124 0.2518 0.2834
0.0124 0.4594 0.6647
0.0066 0.736 1
0.0059 0.4258 0.9766
0.0074 0.7855 1
0.0061 0.2858 0.2858
0.0072 0.724 0.9752
0.0067 0.7855 1
0.0072 0.2677 0.2677
0.0067 0.266 0.2611
0.0661 0.3903 0.3819
0.0129 0.3372 0.4958
0.0062 0.724 0.9167
0.0066 0.724 1
0.0068 0.7437 1
0.0072 0.724 0.9752
0.0072 0.2881 0.2881
0.1564 0.6829 0.6819
0.0414 0.2508 0.2626
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0.0617 0.4381 0.7353
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0.0065