Detailed view for EgrG_000734400

Basic information

TDR Targets ID: 587748
Echinococcus granulosus, uridine phosphorylase 1
Source Database / ID:  GeneDB

pI: 6.7992 | Length (AA): 346 | MW (Da): 38297 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01048   Phosphorylase superfamily

Gene Ontology

Mouse over links to read term descriptions.
GO:0005737   cytoplasm  
GO:0004850   uridine phosphorylase activity  
GO:0003824   catalytic activity  
GO:0009166   nucleotide catabolic process  
GO:0009116   nucleoside metabolic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
46 346 3ku4 (A) 15 306 52.00 0 1 1.52764 -0.94
55 346 3p0f (A) 24 313 48.00 0 1 1.51343 -0.98

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131462)

Species Accession Gene Product
Brugia malayi Bm1_10125   uridine phosphorylase family protein
Caenorhabditis elegans CELE_ZK783.2   Protein UPP-1
Drosophila melanogaster Dmel_CG3788   CG3788 gene product from transcript CG3788-RB
Drosophila melanogaster Dmel_CG6330   CG6330 gene product from transcript CG6330-RB
Echinococcus granulosus EgrG_000734400   uridine phosphorylase 1
Echinococcus multilocularis EmuJ_000734400   uridine phosphorylase 1
Homo sapiens ENSG00000007001   uridine phosphorylase 2
Homo sapiens ENSG00000183696   uridine phosphorylase 1
Loa Loa (eye worm) LOAG_06997   uridine phosphorylase
Mycobacterium leprae ML2177c   probable uridine phosphorylase
Mus musculus ENSMUSG00000020407   uridine phosphorylase 1
Mus musculus ENSMUSG00000026839   uridine phosphorylase 2
Schistosoma japonicum Sjp_0060020   ko:K00757 uridine phosphorylase [EC2.4.2.3], putative
Schistosoma japonicum Sjp_0118170   ko:K00757 uridine phosphorylase [EC2.4.2.3], putative
Schistosoma mansoni Smp_082420   uridine phosphorylase
Schistosoma mansoni Smp_082430   uridine phosphorylase
Schmidtea mediterranea mk4.001217.05  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens uridine phosphorylase 1 Compounds References
Mus musculus uridine phosphorylase 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.2369 0.5 0.5
0.1188 1 1
0.178 1 1
0.2281 0.4566 1
0.1205 1 1
0.0901 0.3068 0.3062
0.0226 0.2535 0.5037
0.0226 0.7163 1
0.23 1 1
0.0988 0.6013 1
0.2281 0.4566 1
0.075 1 1
0.2537 1 1
0.0458 0.4022 0.4202
0.1492 0.2666 0
0.1181 0.5 0.5
0.2288 0.365 0.365
0.2864 0.5 0.5
0.0226 0.4572 0.6106
0.0863 0.3352 1
0.0842 0.5 0.5
0.0226 0.3059 0.3059
0.0206 1 1
0.0371 1 1
0.0183 0.3064 0.8669
0.2453 0.5 0.5
0.1544 1 1
0.1696 0.2827 0.278
0.1746 0.2673 0.2673
0.2507 1 1
0.0202 0.281 0.4376
0.2254 1 1
0.2306 1 1
0.2507 1 1
0.1205 0.5 0.5
0.1468 1 1
0.1174 1 1
0.0758 1 1
0.1732 0.2917 0.2917
0.2392 1 1
0.235 0.5 0.5
0.0637 1 1
0.1453 0.2923 0.2923
0.1957 0.7385 1
0.1317 1 1
0.039 0.8451 0.8659
0.2281 0.4566 1
0.2339 1 1
0.2288 1 1
0.1125 0.2944 0.2942
0.1468 1 1
0.2507 1 1
0.0226 0.3076 0.325
0.0961 0.2813 0.2813
0.1495 0.3047 0.3044
0.2466 0.9132 1
0.1473 0.2771 0.272
0.2281 0.4566 1
0.2281 0.4566 1
0.0252 1 0.5
0.2819 0.4287 1
0.1453 0.2923 0.2923
0.138 1 1
0.1175 0.2901 0.2877
0.0755 0.2681 0.2631
0.0988 0.6013 1
0.1508 0.2655 0.2655
0.1171 0.5 0.5
0.0996 1 1
0.2846 1 1
0.2429 1 1
0.0777 1 1
0.1314 0.2921 0
0.0226 0.3076 0.325
0.0842 0.5 0.5
0.1006 0.5 0.5
0.0226 0.5 0.5
0.02 0.273 0.489
0.1862 1 1
0.0226 0.3203 0.7288
0.0735 1 0.5
0.1503 0.2939 0.2939
0.2281 0.4566 1
0.1957 0.7385 1
0.1853 1 1
0.0755 0.2681 0.2631
0.2507 1 1
0.1453 0.2923 0.2923
0.0385 0.4852 1
0.3339 1 1
0.0452 0.5 0.5
0.1898 1 1
0.2904 1 1
0.4277 1 1
0.0901 0.3068 0.3062
0.2525 1 1
0.2281 0.4566 1
0.138 1 1
0.2354 1 1
0.1485 0.2987 0.2982
0.0735 1 0.5
0.0226 0.9966 1
0.1414 1 1
0.0186 0.2538 0.2532
0.1035 0.7488 0.7488
0.0198 1 1
0.1623 0.3172 1
0.0863 0.3352 1
0.1205 1 1
0.2306 1 1
0.1378 0.5 0.5
0.2429 1 1
0.0399 0.891 1
0.0186 0.2538 0.2532
0.2466 0.9132 1
0.2466 0.9132 1
0.2288 0.365 0.365
0.1468 1 1
0.2335 1 1
0.186 1 1
0.0784 0.5604 0.5604
0.2281 0.4566 1
0.1404 1 1
0.1597 0.7851 0.7849
0.0226 0.2535 0.5037
0.2339 0.5 0.5
0.1205 1 1
0.1453 0.2923 0.2923
0.2507 1 1
0.2352 0.5 0.5
0.2392 1 1
0.0371 1 1
0.1715 0.2964 0.2964
0.0755 0.2681 0.2631
0.021 0.9509 0.9499
0.0226 1 1
0.2288 0.365 0.365
0.0624 0.293 0.293
0.1357 0.2878 0.2877
0.2254 1 1
0.238 1 1
0.0226 0.2677 0.2669
0.2323 1 1
0.0226 0.3059 0.3059
0.0388 0.5 0.5
0.186 1 1
0.1208 1 1
0.112969 0.288801 0.288488
0.0366 0.4351 0.435
0.2392 1 1
0.02 1 1
0.0637 1 1
0.2316 1 1
0.1768 0.2963 0.2963
0.1389 1 1
0.0637 1 1
0.2306 1 1
0.1105 0.2977 0.2952
0.1998 1 0.5
0.2281 0.4566 1
0.0226 0.2677 0.2669
0.0226 0.4794 0.832
0.1314 0.2921 0
0.2127 1 1
0.14 1 1
0.1503 0.2939 0.2939
0.1526 0.273 0.273
0.3339 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EgrG_000734400 (Echinococcus granulosus), uridine phosphorylase 1
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