pI: 5.5439 |
Length (AA): 708 |
MW (Da): 78538 |
Paralog Number:
9
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 598 | 4f4c (A) | 397 | 1096 | 37.00 | 0 | 1 | 1.18423 | 0.64 |
17 | 258 | 2ixe (A) | 475 | 717 | 44.00 | 0 | 1 | 1.03358 | -1.19 |
18 | 262 | 3wmg (A) | 439 | 688 | 51.00 | 0 | 1 | 1.0522 | -0.71 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126596)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G28860 | ABC transporter B family member 19 |
Arabidopsis thaliana | AT1G02530 | P-glycoprotein 12 |
Arabidopsis thaliana | AT1G27940 | ABC transporter B family member 13 |
Arabidopsis thaliana | AT4G25960 | P-glycoprotein 2 |
Arabidopsis thaliana | AT3G28345 | ABC transporter B family member 15 |
Arabidopsis thaliana | AT2G36910 | ABC transporter B family member 1 |
Arabidopsis thaliana | AT1G28010 | ABC transporter B family member 14 |
Arabidopsis thaliana | AT1G02520 | P-glycoprotein 11 |
Arabidopsis thaliana | AT2G39480 | ABC transporter B family member 6 |
Arabidopsis thaliana | AT3G55320 | ABC transporter B family member 20 |
Arabidopsis thaliana | AT3G62150 | ABC transporter B family member 21 |
Arabidopsis thaliana | AT4G01830 | ABC transporter B family member 5 |
Arabidopsis thaliana | AT3G28390 | ABC transporter B family member 18 |
Arabidopsis thaliana | AT3G28360 | ABC transporter B family member 16 |
Arabidopsis thaliana | AT1G10680 | ABC transporter B family member 10 |
Arabidopsis thaliana | AT5G46540 | ABC transporter B family member 7 |
Arabidopsis thaliana | AT2G47000 | auxin efflux transmembrane transporter MDR4 |
Arabidopsis thaliana | AT3G28380 | ABC transporter B family member 17 |
Arabidopsis thaliana | AT4G18050 | P-glycoprotein 9 |
Arabidopsis thaliana | AT4G01820 | ABC transporter B family member 3 |
Arabidopsis thaliana | AT3G28415 | ABC transporter B family member 22 |
Brugia malayi | Bm1_43165 | ABC transporter family protein |
Brugia malayi | Bm1_24870 | multidrug resistance protein 3 |
Candida albicans | CaO19.7440 | potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export |
Caenorhabditis elegans | CELE_K08E7.9 | Protein PGP-1 |
Caenorhabditis elegans | CELE_T21E8.3 | Protein PGP-8 |
Caenorhabditis elegans | CELE_DH11.3 | Protein PGP-11 |
Caenorhabditis elegans | CELE_T21E8.1 | Protein PGP-6, isoform B |
Caenorhabditis elegans | CELE_F22E10.2 | Protein PGP-13 |
Caenorhabditis elegans | CELE_F42E11.1 | Protein PGP-4, isoform B |
Caenorhabditis elegans | CELE_C34G6.4 | Protein PGP-2 |
Caenorhabditis elegans | CELE_C05A9.1 | Protein PGP-5, isoform B |
Caenorhabditis elegans | CELE_T21E8.2 | Protein PGP-7 |
Caenorhabditis elegans | CELE_F22E10.3 | Protein PGP-14 |
Caenorhabditis elegans | CELE_C47A10.1 | Protein PGP-9 |
Caenorhabditis elegans | CELE_ZK455.7 | Protein PGP-3 |
Caenorhabditis elegans | CELE_F22E10.1 | Protein PGP-12 |
Cryptosporidium hominis | Chro.60540 | ATP-binding cassette protein 3 |
Cryptosporidium parvum | cgd6_4700 | ATP-binding cassette transporter |
Chlamydia trachomatis | CT_264 | ABC transporter ATP binding protein/permease |
Dictyostelium discoideum | DDB_G0291714 | ABC transporter B family protein |
Dictyostelium discoideum | DDB_G0293438 | ABC transporter B family protein |
Drosophila melanogaster | Dmel_CG10181 | Multiple drug resistance 65 |
Drosophila melanogaster | Dmel_CG8523 | Multi drug resistance 50 |
Drosophila melanogaster | Dmel_CG10226 | CG10226 gene product from transcript CG10226-RA |
Drosophila melanogaster | Dmel_CG3879 | Multi drug resistance 49 |
Escherichia coli | b0914 | fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component |
Escherichia coli | b0449 | putative multidrug transporter subunit of ABC superfamily, ATP-binding component |
Echinococcus granulosus | EgrG_000901300 | ATP binding cassette subfamily B MDR:TAP |
Echinococcus granulosus | EgrG_002002700 | multidrug resistance protein 1 |
Echinococcus granulosus | EgrG_000160100 | multidrug resistance protein 1 |
Echinococcus granulosus | EgrG_000159900 | multidrug resistance protein 1 |
Echinococcus granulosus | EgrG_000931700 | ATP binding cassette subfamily B MDR:TAP |
Echinococcus granulosus | EgrG_000160300 | multidrug resistance protein 1 |
Echinococcus granulosus | EgrG_000161100 | 5'partial|ATP binding cassette sub family B |
Echinococcus granulosus | EgrG_000901000 | ATP binding cassette subfamily B MDR:TAP |
Echinococcus granulosus | EgrG_000777700 | ATP binding cassette subfamily B MDR:TAP |
Echinococcus granulosus | EgrG_000900900 | multidrug resistance protein 1 |
Entamoeba histolytica | EHI_186350 | P-glycoprotein-2 |
Entamoeba histolytica | EHI_125030 | P-glycoprotein 5, putative |
Entamoeba histolytica | EHI_175450 | P-glycoprotein-5 |
Entamoeba histolytica | EHI_114150 | P-glycoprotein-1 |
Entamoeba histolytica | EHI_186600 | P-glycoprotein-2, putative |
Entamoeba histolytica | EHI_101230 | P-glyco protein 6, putative |
Entamoeba histolytica | EHI_016380 | P-glycoprotein-2 |
Echinococcus multilocularis | EmuJ_000931700 | ATP binding cassette subfamily B (MDR:TAP) |
Echinococcus multilocularis | EmuJ_000161100 | ATP binding cassette sub family B |
Echinococcus multilocularis | EmuJ_000159900 | multidrug resistance protein 1 |
Echinococcus multilocularis | EmuJ_000777700 | ATP binding cassette subfamily B (MDR:TAP) |
Echinococcus multilocularis | EmuJ_000900900 | multidrug resistance protein 1 |
Echinococcus multilocularis | EmuJ_000160100 | multidrug resistance protein 1 |
Echinococcus multilocularis | EmuJ_000160300 | ATP binding cassette subfamily B (MDR:TAP) |
Echinococcus multilocularis | EmuJ_000901300 | ATP binding cassette subfamily B (MDR:TAP) |
Echinococcus multilocularis | EmuJ_000901000 | ATP binding cassette subfamily B (MDR:TAP) |
Homo sapiens | ENSG00000004846 | ATP-binding cassette, sub-family B (MDR/TAP), member 5 |
Homo sapiens | ENSG00000005471 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 |
Homo sapiens | ENSG00000073734 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
Homo sapiens | ENSG00000085563 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
Leishmania braziliensis | LbrM.26.2600 | p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein |
Leishmania donovani | LdBPK_341060.1 | p-glycoprotein |
Leishmania donovani | LdBPK_262700.1 | ATP-binding cassette protein subfamily B, member 2, putative |
Leishmania infantum | LinJ.26.2700 | ATP-binding cassette protein subfamily B, member 2, putative |
Leishmania infantum | LinJ.34.1060 | p-glycoprotein |
Leishmania major | LmjF.26.2670 | ATP-binding cassette protein subfamily B, member 2, putative |
Leishmania major | LmjF.34.0990 | p-glycoprotein |
Leishmania mexicana | LmxM.26.2670 | p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein |
Leishmania mexicana | LmxM.33.0990 | p-glycoprotein |
Loa Loa (eye worm) | LOAG_07988 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06601 | multidrug resistance protein 3 |
Loa Loa (eye worm) | LOAG_03722 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05152 | ATP-binding cassette sub-family B member 2 |
Loa Loa (eye worm) | LOAG_11527 | hypothetical protein |
Mus musculus | ENSMUSG00000040584 | ATP-binding cassette, sub-family B (MDR/TAP), member 1A |
Mus musculus | ENSMUSG00000072791 | ATP-binding cassette, sub-family B (MDR/TAP), member 5 |
Mus musculus | ENSMUSG00000027048 | ATP-binding cassette, sub-family B (MDR/TAP), member 11 |
Mus musculus | ENSMUSG00000028970 | ATP-binding cassette, sub-family B (MDR/TAP), member 1B |
Mus musculus | ENSMUSG00000042476 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 |
Mycobacterium tuberculosis | Rv0194 | Probable transmembrane multidrug efflux pump |
Neospora caninum | NCLIV_026720 | ATP-binding cassette, sub-family B (MDR/TAP), member 4, related |
Neospora caninum | NCLIV_015830 | hypothetical protein |
Oryza sativa | 4339511 | Os05g0548300 |
Oryza sativa | 4337173 | Os04g0642000 |
Oryza sativa | 4328568 | Os02g0190000 |
Oryza sativa | 4332438 | Os03g0280000 |
Oryza sativa | 4324720 | Os01g0723800 |
Oryza sativa | 4330390 | Os02g0693700 |
Oryza sativa | 4324305 | Os01g0976100 |
Oryza sativa | 9270100 | Os02g0323000 |
Oryza sativa | 9268765 | Os01g0534700 |
Oryza sativa | 4328566 | Os02g0189800 |
Oryza sativa | 4336042 | Os04g0459000 |
Oryza sativa | 4346344 | Os08g0564300 |
Oryza sativa | 4328570 | Os02g0190300 |
Oryza sativa | 9270932 | Os05g0137100 |
Oryza sativa | 9269254 | Os02g0190101 |
Oryza sativa | 4326410 | Os01g0533900 |
Oryza sativa | 4336189 | Os04g0481700 |
Onchocerca volvulus | OVOC10280 |
|
Plasmodium berghei | PBANKA_1237800 | multidrug resistance protein 1, putative |
Plasmodium falciparum | PF3D7_0523000 | multidrug resistance protein 1 |
Plasmodium knowlesi | PKNH_1009900 | multidrug resistance protein 1, putative |
Plasmodium vivax | PVX_080100 | multidrug resistance protein 1, putative |
Plasmodium yoelii | PY00245 | multidrug resistance protein |
Saccharomyces cerevisiae | YKL209C | ATP-binding cassette alpha-factor transporter STE6 |
Schistosoma japonicum | Sjp_0093230 | Multidrug resistance protein 1, putative |
Schistosoma japonicum | Sjp_0122070 | Multidrug resistance protein 3, putative |
Schistosoma japonicum | Sjp_0072980 | Multidrug resistance protein 1, putative |
Schistosoma japonicum | Sjp_0107590 | Multidrug resistance protein 1, putative |
Schistosoma japonicum | Sjp_0031160 | Bile salt export pump, putative |
Schistosoma japonicum | Sjp_0066120 | ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative |
Schistosoma japonicum | Sjp_0122750 | Multidrug resistance protein 2, putative |
Schistosoma japonicum | Sjp_0012730 | Multidrug resistance protein 1, putative |
Schistosoma japonicum | Sjp_0039970 | ATP-binding cassette sub-family B member 5, putative |
Schistosoma japonicum | Sjp_0093240 | Multidrug resistance protein 3, putative |
Schistosoma mansoni | Smp_137080 | multidrug resistance protein |
Schistosoma mansoni | Smp_170820 | multidrug resistance protein |
Schistosoma mansoni | Smp_089200 | multidrug resistance protein |
Schistosoma mansoni | Smp_055780 | smdr2 |
Schmidtea mediterranea | mk4.011204.00 | |
Schmidtea mediterranea | mk4.020366.01 | Multidrug resistance protein 1, 2, 3 |
Schmidtea mediterranea | mk4.020420.00 | |
Schmidtea mediterranea | mk4.000357.04 | |
Schmidtea mediterranea | mk4.005899.00 | |
Schmidtea mediterranea | mk4.012079.01 | |
Schmidtea mediterranea | mk4.020228.00 | Multidrug resistance protein 1, 2, 3 |
Schmidtea mediterranea | mk4.026452.00 | |
Schmidtea mediterranea | mk4.012079.00 | |
Schmidtea mediterranea | mk4.013711.03 | |
Schmidtea mediterranea | mk4.046452.00 | |
Schmidtea mediterranea | mk4.005899.01 | |
Schmidtea mediterranea | mk4.000357.05 | |
Schmidtea mediterranea | mk4.010001.00 | |
Schmidtea mediterranea | mk4.000357.01 | Multidrug resistance protein 1, 2, 3 |
Toxoplasma gondii | TGME49_239020 | ABC transporter transmembrane region domain-containing protein |
Toxoplasma gondii | TGME49_260310 | ATP-binding cassette transporter ABC.B1 |
Trichomonas vaginalis | TVAG_190320 | lipid A export ATP-binding/permease protein msba, putative |
Trichomonas vaginalis | TVAG_147100 | ABC transporter, putative |
Trichomonas vaginalis | TVAG_049020 | ATP-binding cassette transporter, putative |
Trichomonas vaginalis | TVAG_127410 | lipid A export ATP-binding/permease protein msba, putative |
Trichomonas vaginalis | TVAG_223680 | ABC transporter, half transporter, putative |
Trichomonas vaginalis | TVAG_188980 | lipid A export ATP-binding/permease protein msba, putative |
Trichomonas vaginalis | TVAG_070890 | ATP-binding cassette transporter, putative |
Trichomonas vaginalis | TVAG_352350 | lipid A export ATP-binding/permease protein msba, putative |
Trichomonas vaginalis | TVAG_190330 | lipid A export ATP-binding/permease protein msba, putative |
Trichomonas vaginalis | TVAG_078520 | abcb9, putative |
Trichomonas vaginalis | TVAG_139960 | multidrug resistance protein 1, 2, putative |
Trichomonas vaginalis | TVAG_487000 | multidrug resistance protein 1, 2, putative |
Trichomonas vaginalis | TVAG_162060 | ATP-binding cassette transporter, putative |
Trichomonas vaginalis | TVAG_145830 | multidrug resistance protein 1, 2, putative |
Trichomonas vaginalis | TVAG_088690 | abcb9, putative |
Trichomonas vaginalis | TVAG_494720 | ABC transporter, putative |
Trichomonas vaginalis | TVAG_352380 | taga, putative |
Trichomonas vaginalis | TVAG_381050 | lipid A export ATP-binding/permease protein msba, putative |
Trichomonas vaginalis | TVAG_280000 | lipid A export ATP-binding/permease protein msba, putative |
Trichomonas vaginalis | TVAG_241640 | ATP-binding cassette transporter, putative |
Trichomonas vaginalis | TVAG_124750 | multidrug resistance protein 1, 2, putative |
Trichomonas vaginalis | TVAG_109910 | ABC transporter, putative |
Trichomonas vaginalis | TVAG_352360 | ATP-binding cassette transporter, putative |
Trichomonas vaginalis | TVAG_373020 | ABC transporter, half transporter, putative |
Trichomonas vaginalis | TVAG_352390 | ATP-binding cassette transporter, putative |
Trichomonas vaginalis | TVAG_542450 | multidrug resistance protein 1, 2, putative |
Trichomonas vaginalis | TVAG_172140 | abcb9, putative |
Trichomonas vaginalis | TVAG_209070 | multidrug resistance protein 1, 2, putative |
Trichomonas vaginalis | TVAG_494730 | lipid A export ATP-binding/permease protein msba, putative |
Trichomonas vaginalis | TVAG_542460 | multidrug resistance protein 1, 2, putative |
Trichomonas vaginalis | TVAG_219580 | ABC transporter, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu196 | Mycobacterium tuberculosis | non-essential | nmpdr |
b0449 | Escherichia coli | non-essential | goodall |
b0914 | Escherichia coli | essential | goodall |
CELE_C47A10.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_1237800 | Plasmodium berghei | Essential | plasmo |
TGME49_260310 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_239020 | Toxoplasma gondii | Essentiality uncertain | sidik |
TGME49_260310 | Toxoplasma gondii | Probably non-essential | sidik |
TGME49_239020 | Toxoplasma gondii | Probably non-essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | ATP-binding cassette, sub-family B (MDR/TAP), member 1A | Compounds | References |
Mus musculus | ATP-binding cassette, sub-family B (MDR/TAP), member 1B | Compounds | References |
Homo sapiens | ATP-binding cassette, sub-family B (MDR/TAP), member 11 | Compounds | References |
Rattus norvegicus | Bile salt export pump | Compounds | References |
Homo sapiens | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | Compounds | References |