Detailed view for EgrG_000638200

Basic information

TDR Targets ID: 588323
Echinococcus granulosus, zinc phosphodiesterase
Source Database / ID:  GeneDB

pI: 7.5182 | Length (AA): 852 | MW (Da): 95082 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00753   Metallo-beta-lactamase superfamily
PF13691   tRNase Z endonuclease

Gene Ontology

Mouse over links to read term descriptions.
GO:0008033   tRNA processing  

Metabolic Pathways

RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
44 814 5mtz (A) 25 818 18.00 0 0.95 1.01653 0.75
54 810 5mtz (A) 35 814 25.00 0 1 0.987198 0.66
451 674 4hl2 (A) 31 249 13.00 0 0.74 0.435811 -0.29
478 788 3zwf (A) 4 359 36.00 0 1 0.468723 0.41
478 788 1y44 (A) 2 304 33.00 0 0.91 0.498723 0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126816)

Species Accession Gene Product
Arabidopsis thaliana AT1G52160   tRNAse Z3
Arabidopsis thaliana AT3G16260   tRNAse Z4
Babesia bovis BBOV_IV000940   hypothetical protein
Brugia malayi Bm1_43440   metallo-beta-lactamase superfamily protein
Candida albicans CaO19.12880   similar to S. cerevisiae YKR079C essential tRNA 3' processing endoribonuclease
Candida albicans CaO19.5425   similar to S. cerevisiae YKR079C essential tRNA 3' processing endoribonuclease
Caenorhabditis elegans CELE_E04A4.4   Protein HOE-1, isoform B
Cryptosporidium hominis Chro.70186   hypothetical protein
Cryptosporidium parvum cgd7_1580   mbl domain containing protein
Chlamydia trachomatis CT_346   ribonuclease Z
Dictyostelium discoideum DDB_G0276531   hypothetical protein
Dictyostelium discoideum DDB_G0276633   hypothetical protein
Dictyostelium discoideum DDB_G0277337   beta-lactamase family protein
Dictyostelium discoideum DDB_G0290623   hypothetical protein
Drosophila melanogaster Dmel_CG3298   Juvenile hormone-inducible protein 1
Escherichia coli b2268   RNase BN, tRNA processing enzyme
Echinococcus granulosus EgrG_000638200   zinc phosphodiesterase
Echinococcus granulosus EgrG_000149350   zinc phosphodiesterase elac protein 1
Entamoeba histolytica EHI_125880   metallo-beta-lactamase domain-containing protein
Entamoeba histolytica EHI_136340   metallo-beta-lactamase domain-containing protein
Echinococcus multilocularis EmuJ_000638200   zinc phosphodiesterase
Echinococcus multilocularis EmuJ_000149350   zinc phosphodiesterase elac protein 1
Giardia lamblia GL50803_6497   Metal-dependent hydrolase
Giardia lamblia GL50803_16246   Prostate cancer susceptibility protein-like protein
Homo sapiens 60528   elaC ribonuclease Z 2
Homo sapiens ENSG00000141642   elaC ribonuclease Z 1
Loa Loa (eye worm) LOAG_01193   metallo-beta-lactamase superfamily protein
Mus musculus ENSMUSG00000020549   elaC homolog 2 (E. coli)
Mus musculus ENSMUSG00000036941   elaC homolog 1 (E. coli)
Mycobacterium tuberculosis Rv2407   Conserved hypothetical protein
Mycobacterium ulcerans MUL_3670   ribonuclease Z
Neospora caninum NCLIV_027920   hypothetical protein, conserved
Neospora caninum NCLIV_050180   Ribonuclease Z (EC 3.1.26.11), related
Oryza sativa 4324278   Os01g0232300
Plasmodium berghei PBANKA_0621200   metallo-hydrolase/oxidoreductase, putative
Plasmodium berghei PBANKA_1328700   tRNA 3'-trailer sequence RNase, putative
Plasmodium falciparum PF3D7_0723700   metallo-hydrolase/oxidoreductase, putative
Plasmodium falciparum PF3D7_1465300   tRNA 3'-trailer sequence RNase, putative
Plasmodium knowlesi PKNH_1216200   tRNA 3'-trailer sequence RNase, putative
Plasmodium knowlesi PKNH_0319100   metallo-hydrolase/oxidoreductase, putative
Plasmodium vivax PVX_117195   hypothetical protein, conserved
Plasmodium yoelii PY05503   similar to elaC homolog 1
Plasmodium yoelii PY01370   unknown protein
Saccharomyces cerevisiae YKR079C   Trz1p
Schistosoma japonicum Sjp_0307380   Zinc phosphodiesterase ELAC protein 2, putative
Schistosoma japonicum Sjp_0069070   ko:K00784 ribonuclease Z [EC3.1.26.11], putative
Schistosoma mansoni Smp_068090   zinc phosphodiesterase
Schistosoma mansoni Smp_031040.1   zinc phosphodiesterase
Schistosoma mansoni Smp_031040.2   zinc phosphodiesterase
Schmidtea mediterranea mk4.003479.01  
Schmidtea mediterranea mk4.013400.00  
Toxoplasma gondii TGME49_258590   hypothetical protein
Toxoplasma gondii TGME49_235905   ribonuclease z, putative
Treponema pallidum TP0819   ribonuclease Z
Theileria parva TP01_0117   hypothetical protein
Theileria parva TP04_0416   hypothetical protein
Theileria parva TP01_0116   hypothetical protein
Trichomonas vaginalis TVAG_465870   zinc phosphodiesterase, putative
Trichomonas vaginalis TVAG_483060   zinc phosphodiesterase, putative
Trichomonas vaginalis TVAG_476000   zinc phosphodiesterase, putative
Trichomonas vaginalis TVAG_485290   zinc phosphodiesterase, putative

Essentiality

EgrG_000638200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu2449 Mycobacterium tuberculosis non-essential nmpdr
b2268 Escherichia coli non-essential goodall
CELE_E04A4.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_E04A4.4 Caenorhabditis elegans slow growth wormbase
YKR079C Saccharomyces cerevisiae inviable yeastgenome
PBANKA_1328700 Plasmodium berghei Essential plasmo
TGME49_258590 Toxoplasma gondii Probably essential sidik
TGME49_235905 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0367 0.531 0.531
0.0115 1 1
0.03 0.9089 0.908
0.0286 1 1
0.024 0.347 0.347
0.0138 0.8072 0.8072
0.035 0.2506 0.2506
0.0404 0.2792 0.2792
0.0156 1 1
0.0065 0.5 0.5
0.0088 0.4106 0.313
0.0085 0.271 0.2164
0.0249 0.3365 0.3357
0.0031 0.5 0.5
0.0101 0.5 0.5
0.032 0.4025 0.3998
0.0134 0.3422 0.3422
0.0282 0.3876 0.3838
0.0259 0.336 0.3327
0.0153 1 1
0.0173 0.5058 0.505
0.0019 0.5 0.5
0.0098 0.5 0.5
0.0333 0.487 0.4866
0.0161 1 1
0.0151 0.5 0.5
0.0051 0.5023 0.5
0.0284 0.6112 0.6088
0.0141 0.5 0.5
0.0068 0.616 1
0.0139 0.3313 0.3248
0.0153 1 1
0.0215 0.5175 0.5
0.0183 1 1
0.0304 0.3722 0.4049
0.0079 0.301 1
0.0101 0.5 0.5
0.0208 0.4509 0.4573
0.0263 0.5703 0.7744
0.0033 0.5 0.5
0.0307 0.4131 0.4131
0.0304 0.3722 0.4049
0.0224 1 1
0.03 0.9089 0.908

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EgrG_000638200 (Echinococcus granulosus), zinc phosphodiesterase
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