Detailed view for EgrG_000993000

Basic information

TDR Targets ID: 589604
Echinococcus granulosus, histone lysine N methyltransferase MLL3

Source Database / ID:  GeneDB

pI: 8.4172 | Length (AA): 1638 | MW (Da): 180567 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00856   SET domain
PF05964   F/Y-rich N-terminus
PF05965   F/Y rich C-terminus
PF13771   PHD-like zinc-binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0042800   histone lysine N-methyltransferase activity (H3-K4 specific)  
GO:0044666   GO:MLL3/4 complex  

GO:0005634   nucleus  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 76 2khm (A) 28 90 24.00 0.77 0.07 0.319262 -0.8
1099 1206 4nn2 (A) 209 329 19.00 0 0.99 0.286234 -0.75
1159 1211 2lq6 (A) 324 393 34.00 0 0.8 0.136657 -0.28
1402 1620 3cbp (A) 129 350 23.00 0 1 0.28 0.3
1482 1638 5f6k (C) 4755 4911 60.00 0 1 0.796449 -0.6

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129279)

Species Accession Gene Product
Brugia malayi Bm1_21795   F/Y-rich N-terminus family protein
Caenorhabditis elegans CELE_T12D8.1   Protein SET-16
Cryptosporidium hominis Chro.80599   hypothetical protein
Cryptosporidium parvum cgd8_5250   protein with 2x PHD domains
Dictyostelium discoideum DDB_G0282427   HMG1/2 box-containing protein
Drosophila melanogaster Dmel_CG3848   trithorax-related
Drosophila melanogaster Dmel_CG5591   Lost PHDs of trr
Echinococcus granulosus EgrG_000993000   histone lysine N methyltransferase MLL3
Echinococcus granulosus EgrG_000899100   histone lysine N methyltransferase MLL3
Echinococcus granulosus EgrG_000101600   histone lysine N methyltransferase MLL3
Echinococcus multilocularis EmuJ_000993000   histone lysine N methyltransferase MLL3
Echinococcus multilocularis EmuJ_000899100   histone lysine N methyltransferase MLL3
Echinococcus multilocularis EmuJ_000101600   histone lysine N methyltransferase MLL3
Homo sapiens ENSG00000167548   lysine (K)-specific methyltransferase 2D
Homo sapiens ENSG00000055609   lysine (K)-specific methyltransferase 2C
Loa Loa (eye worm) LOAG_02985   F/Y-rich family protein
Loa Loa (eye worm) LOAG_10649   histone methyltransferase
Mus musculus ENSMUSG00000038056   lysine (K)-specific methyltransferase 2C
Mus musculus ENSMUSG00000048154   lysine (K)-specific methyltransferase 2D
Schistosoma japonicum Sjp_0311570   Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog, putative
Schistosoma japonicum Sjp_0019560   Myeloid/lymphoid or mixed-lineage leukemia protein 2, putative
Schistosoma mansoni Smp_138030   mixed-lineage leukemia protein mll
Schistosoma mansoni Smp_152730.3   myst-related protein
Schistosoma mansoni Smp_152730.2   myst-related protein
Schmidtea mediterranea mk4.007060.00   Myst-related protein
Schmidtea mediterranea mk4.007060.01  
Schmidtea mediterranea mk4.003120.01   Histone-lysine N-methyltransferase trr
Schmidtea mediterranea mk4.000684.12   Trr-1

Essentiality

EgrG_000993000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T12D8.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_T12D8.1 Caenorhabditis elegans larval lethal wormbase
CELE_T12D8.1 Caenorhabditis elegans slow growth wormbase
CELE_T12D8.1 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier EgrG_000993000 (Echinococcus granulosus), histone lysine N methyltransferase MLL3
Title for this comment
Comment