Detailed view for EgrG_000356400

Basic information

TDR Targets ID: 589918
Echinococcus granulosus, g protein coupled receptor
Source Database / ID:  GeneDB

pI: 10.123 | Length (AA): 416 | MW (Da): 47091 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 6

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10324   Serpentine type 7TM GPCR chemoreceptor Srw

Gene Ontology

Mouse over links to read term descriptions.
GO:0008528   peptide receptor activity, G-protein coupled  
GO:0016021   integral to membrane  
GO:0004930   G-protein coupled receptor activity  
GO:0007186   G-protein coupled receptor protein signaling pathway  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 44 4yay (A) 24 58 20.00 0.35 0.03 -0.0751654 3.21
240 354 5u09 (A) 1172 412 29.00 0.53 0.03 0.157942 1.97

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_138685)

Species Accession Gene Product
Caenorhabditis elegans CELE_B0334.6   Protein B0334.6
Drosophila melanogaster Dmel_CG6986   Proctolin receptor
Echinococcus granulosus EgrG_000356400   g protein coupled receptor
Echinococcus granulosus EgrG_000836800   7tm_1 domain containing protein
Echinococcus multilocularis EmuJ_000356400   g protein coupled receptor
Homo sapiens 124274   G protein-coupled receptor 139
Loa Loa (eye worm) LOAG_02548   hypothetical protein
Mus musculus ENSMUSG00000066197   G protein-coupled receptor 139
Onchocerca volvulus OVOC10230  
Schmidtea mediterranea mk4.030476.00  
Schmidtea mediterranea mk4.022218.00  
Schmidtea mediterranea mk4.001381.00  
Schmidtea mediterranea mk4.000928.03  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens G protein-coupled receptor 139 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Oryctolagus cuniculus Growth hormone secretagogue receptor type 1 366 aa 24.0% 338 aa Compounds References
Sus scrofa Ghrelin receptor 366 aa 23.8% 340 aa Compounds References
Rattus norvegicus Ghrelin receptor 364 aa 23.7% 337 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 412 aa 25.1% 335 aa Compounds References
Rattus norvegicus Thyrotropin-releasing hormone receptor 2 352 aa 24.5% 347 aa Compounds References
Macaca mulatta Mu-type opioid receptor 400 aa 22.0% 359 aa Compounds References
Canis lupus familiaris Beta-3 adrenergic receptor 405 aa 19.3% 336 aa Compounds References
Ovis aries Ghrelin receptor 366 aa 24.3% 337 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0559 0.6616 0.97
0.0596 0.7051 0.7048
0.028 0.3313 0.3339
0.0131 0.3198 0.3147
0.0983 0.2909 0.9823
0.0575 0.9825 0.9824
0.0136 0.3371 0.3364
0.0596 0.7051 0.7048
0.0131 0.4494 0.981
0.0135 0.9642 0.9642
0.0163 0.7758 0.7758
0.0265 0.3128 0.7769
0.1599 0.9823 0.9823
0.0134 0.5774 0.9457
0.0272 0.977 0.9756
0.0135 0.9786 0.9753
0.0405 0.9758 0.9758
0.0536 0.6543 0.9796
0.1392 0.3246 0.9798
0.0272 0.6601 0.6564
0.0134 0.282 0.282
0.0261 0.3269 0.4015
0.0991 0.9802 0.9802
0.0983 0.2909 0.9823
0.0407 0.5116 0.9824
0.0596 0.7051 0.7048
0.0989 0.9725 0.9724
0.0554 0.3195 0.9781
0.0405 0.4149 0.4922
0.0265 0.3128 0.7769
0.0273 0.3728 0.5111
0.0945 0.2609 0.2609
0.0983 0.2909 0.9823
0.0945 0.2609 0.2609
0.0132 0.3047 0.3047
0.0263 0.9816 0.9816
0.014 0.2502 0.2502
0.0945 0.2609 0.2609
0.0989 0.975 0.975
0.0265 0.3128 0.7769
0.0264 0.3196 0.5031
0.014 0.2502 0.2502
0.1552 0.4673 0.9811
0.0265 0.3128 0.7769
0.0287 0.9817 0.9817
0.0146 0.9608 0.9607
0.0535 0.6613 0.9823
0.0268 0.2646 0.2646
0.0273 0.4101 0.6254
0.0983 0.2909 0.9823
0.1559 0.9825 0.9825
0.0266 0.9761 0.9408
0.0295 0.9698 0.9693
0.0399 0.484 0.9824
0.0267 0.285 0.285
0.0271 0.9226 0.9225
0.0405 0.4149 0.4922
0.0568 0.6208 0.9795

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000356400 (Echinococcus granulosus), g protein coupled receptor
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