Detailed view for EgrG_000243450

Basic information

TDR Targets ID: 590233
Echinococcus granulosus, DNA polymerase subunit gamma
Source Database / ID:  GeneDB

pI: 8.842 | Length (AA): 1166 | MW (Da): 132604 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00476   DNA polymerase family A

Gene Ontology

Mouse over links to read term descriptions.
GO:0005760   gamma DNA polymerase complex  
GO:0003887   DNA-directed DNA polymerase activity  
GO:0003677   DNA binding  
GO:0006260   DNA replication  

Metabolic Pathways

Global map (KEGG)
Mitophagy - yeast (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 1159 3ikm (A) 70 1239 35.00 0 1 1.14464 1.6
36 1148 4ztu (A) 78 1228 41.00 0 1 1.19235 1.06

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130544)

Species Accession Gene Product
Brugia malayi Bm1_11960   DNA polymerase I family protein
Candida albicans CaO19.10935   Mitochondrial DNA polymerase
Candida albicans CaO19.3431   Mitochondrial DNA polymerase
Caenorhabditis elegans CELE_Y57A10A.15   Protein POLG-1
Drosophila melanogaster Dmel_CG8987   tamas
Echinococcus granulosus EgrG_000243450   DNA polymerase subunit gamma
Echinococcus multilocularis EmuJ_000243450   hypothetical protein
Homo sapiens ENSG00000140521   polymerase (DNA directed), gamma
Loa Loa (eye worm) LOAG_06211   hypothetical protein
Mus musculus ENSMUSG00000039176   polymerase (DNA directed), gamma
Saccharomyces cerevisiae YOR330C   DNA-directed DNA polymerase gamma MIP1
Schistosoma japonicum Sjp_0074730   ko:K02332 DNA polymerase gamma 1, putative
Schistosoma japonicum Sjp_0044640   ko:K02332 DNA polymerase gamma 1, putative
Schistosoma mansoni Smp_161380   DNA polymerase gamma
Schmidtea mediterranea mk4.000704.10   DNA polymerase subunit gamma-1
Schmidtea mediterranea mk4.000469.01  
Schmidtea mediterranea mk4.000704.11   DNA polymerase subunit gamma-1
Schmidtea mediterranea mk4.000704.09   DNA polymerase subunit gamma-1

Essentiality

EgrG_000243450 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_Y57A10A.15 Caenorhabditis elegans embryonic arrest wormbase
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens polymerase (DNA directed), gamma Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0116 0.2781 0.542
0.0111 0.2689 0.3911
0.043 0.3001 1
0.0174 0.3116 1
0.0098 0.2689 0.9511
0.0115 0.2958 1
0.0119 0.2689 1
0.0116 0.2689 1
0.011 0.859 1
0.0101 0.2689 1
0.0098 0.2686 1
0.0112 1 1
0.0101 0.2686 0.81
0.0119 0.2689 1
0.008 0.2521 0.1656
0.0314 0.307 0.4342
0.0099 0.2686 0.8118
0.0097 0.2689 1
0.01 0.2655 0.1755
0.0131071 0.347691 1
0.0115 0.2902 0.7655
0.0131071 0.347691 1
0.0111 0.2689 0.3911
0.0056 0.2686 0.2653
0.0119 0.2689 1
0.0119 0.2689 1
0.0101 0.2912 0.891
0.0314 0.307 0.4342
0.0095 0.2686 1
0.0196 0.3143 0.501
0.0174 0.3116 1
0.0101 0.2912 0.891
0.0115 0.2958 1
0.0195 0.3023 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000243450 (Echinococcus granulosus), DNA polymerase subunit gamma
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