Detailed view for EgrG_000434800

Basic information

TDR Targets ID: 590473
Echinococcus granulosus, terminal deoxycytidyl transferase rev1

Source Database / ID:  GeneDB

pI: 6.7678 | Length (AA): 932 | MW (Da): 102656 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00817   impB/mucB/samB family
PF11799   impB/mucB/samB family C-terminal domain
PF16589   BRCT domain, a BRCA1 C-terminus domain
PF16727   DNA repair protein REV1 C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0042276   error-prone postreplication DNA repair  
GO:0003684   damaged DNA binding  
GO:0016779   nucleotidyltransferase activity  
GO:0006281   DNA repair  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 9 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 105 2ebw (A) 41 132 45.00 0.000000014 1 0.708612 -0.74
18 104 5umv (A) 162 249 37.00 0.00000068 1 0.642248 -1.03
181 700 2oh2 (B) 22 514 25.00 0 1 0.52154 0.73
215 703 3gqc (A) 344 828 39.00 0 1 0.702278 0.29
296 690 3osn (A) 28 398 29.00 0 1 0.46822 0.84
296 702 4j9o (A) 7 432 23.00 0 1 0.524295 0.69
297 698 4f4w (A) 2 340 27.00 0 1 0.55673 0.43
637 839 4mhc (A) 617 872 17.00 0 0.01 0.352411 -0.12
810 920 4ba9 (A) 203 1242 19.00 0.000089 0.5 0.340999 -0.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128628)

Species Accession Gene Product
Arabidopsis thaliana AT5G44750   DNA repair protein REV1
Babesia bovis BBOV_I000470   ImpB/MucB/SamB family protein
Brugia malayi Bm1_00270   ImpB/MucB/SamB family protein
Candida albicans CaO19.4412   Deoxycytidyl transferase
Candida albicans CaO19.11890   Deoxycytidyl transferase
Caenorhabditis elegans CELE_ZK675.2   Protein REV-1
Drosophila melanogaster Dmel_CG12189   CG12189 gene product from transcript CG12189-RA
Echinococcus granulosus EgrG_000434800   terminal deoxycytidyl transferase rev1
Entamoeba histolytica EHI_053480   deoxycytidyl transferase, putative
Echinococcus multilocularis EmuJ_000434800   terminal deoxycytidyl transferase rev1
Giardia lamblia GL50803_6918   DNA damage repair protein
Homo sapiens ENSG00000135945   REV1, polymerase (DNA directed)
Leishmania braziliensis LbrM.35.0170   DNA damage repair protein, putative
Leishmania donovani LdBPK_360110.1   DNA damage repair protein, putative
Leishmania infantum LinJ.36.0110   DNA damage repair protein, putative
Leishmania major LmjF.36.0100   DNA damage repair protein, putative
Leishmania mexicana LmxM.36.0100   DNA damage repair protein, putative
Loa Loa (eye worm) LOAG_02339   ImpB/MucB/SamB family protein
Mus musculus ENSMUSG00000026082   REV1 homolog (S. cerevisiae)
Neospora caninum NCLIV_051220   ImpB/MucB/SamB family protein, related
Oryza sativa 4341904   Os06g0691000
Saccharomyces cerevisiae YOR346W   Rev1p
Schistosoma japonicum Sjp_0005510   ko:K03515 DNA repair protein REV1, putative
Schistosoma japonicum Sjp_0200970   DNA repair protein REV1, putative
Schistosoma mansoni Smp_143760   terminal deoxycytidyl transferase
Schmidtea mediterranea mk4.000676.04   DNA repair protein REV1
Schmidtea mediterranea mk4.000676.03   DNA repair protein REV1
Trypanosoma brucei gambiense Tbg972.10.5510   DNA damage repair protein, putative
Trypanosoma brucei Tb10.v4.0038   chrX additional, unordered contigs
Trypanosoma brucei Tb927.10.4480   DNA damage repair protein, putative
Trypanosoma congolense TcIL3000_10_3680   DNA damage repair protein, putative
Trypanosoma cruzi TcCLB.508625.90   DNA damage repair protein, putative
Trypanosoma cruzi TcCLB.510963.10   DNA damage repair protein, putative

Essentiality

EgrG_000434800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_ZK675.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK675.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0023 0.3387 0.5
0.0023 0.3387 1
0.0038 0.3745 0.5069
0.0155 0.3163 0.4991
0.0019 0.5 0.5
0.0019 1 1
0.0019 0.5 0.5
0.0178 0.261 0.346
0.0041 0.4669 0.4482
0.0022 0.3387 0.5
0.0021 0.4091 0
0.0023 0.4789 0.4238
0.0023 0.3387 0.5
0.0019 0.3387 0.5
0.0034 0.3986 0.3986
0.0205 0.2515 0.4801
0.0023 0.5 0.5
0.0021 0.2714 0.3696
0.0023 0.2731 1
0.0023 0.3387 0.5
0.0023 0.5496 0
0.0228 0.4117 0.5405
0.0085 0.2935 0.4674
0.0023 0.4504 0.4504
0.0252 0.2562 0.3019
0.0023 0.2766 0.3151
0.0023 1 0.5
0.0021 0.3387 0.5
0.0019 1 0.5
0.0039 0.3044 0.3799
0.0038 0.3745 0.5069
0.0041 0.2827 0.0138
0.0023 0.3021 0.4104
0.0226 0.2608 0.5048
0.0019 0.7367 1
0.0023 0.2673 0.3151
0.0023 0.4656 0.4656
0.0019 1 0.5
0.0252 0.2562 0.3019
0.0023 1 1
0.0052 0.2768 0.3008
0.0019 0.3348 0.258
0.0023 1 0.5
0.0023 1 1
0.0339 0.2618 0.2757
0.0019 0.3348 0.2398
0.0023 0.302 0.302
0.0023 0.3181 0.3181
0.0019 1 1
0.0023 0.3387 0.5
0.0023 0.3263 0.3263
0.0023 0.5 0.5
0.0023 0.3387 0.5
0.0023 0.2652 0.2652
0.0019 0.5 0.5
0.0023 1 1
0.0022 1 1
0.0023 0.3342 0.3342
0.0051 0.3224 0.3357
0.0054 0.2573 0.611
0.0246 0.2831 0.2925
0.0023 0.2642 0
0.002 0.3348 0.258
0.0023 0.435 0.435
0.0019 1 1
0.0019 1 1
0.002 0.3348 0.3251
0.0023 0.2766 0.3151
0.0023 0.2652 0.2652
0.0019 0.5 0.5
0.0041 0.5073 0.5073
0.0023 1 0.5
0.0047 0.2946 0.5526
0.0019 0.3348 0.0183
0.0269 0.2762 0.276
0.0414 0.2575 0.256
0.0019 0.3387 0.5
0.0102 0.2596 0.3779
0.0064 0.2671 0.2437
0.0023 0.2615 0.2427
0.0023 1 1
0.002 1 1
0.0019 0.7367 1
0.002 0.3348 0.2398
0.0023 0.315 0.315
0.0023 0.5 0.5
0.006 0.2573 0.611
0.0331 0.2526 0.3171
0.0023 0.4796 0.9435
0.0023 0.3387 0.5
0.0023 0.2753 0.3232
0.0019 0.3022 0
0.0041 0.3986 0.3986
0.0023 0.3387 0.5
0.0038 0.3199 0.1694
0.0023 1 1
0.0019 0.3523 0.0506
0.002 0.2983 0
0.0023 0.2714 0.5837
0.0259 0.2803 0.2776
0.0023 0.3387 0.5
0.0023 0.6344 0.4504
0.0022 1 1
0.0085 0.26 0.3727
0.0023 0.2673 0.3232
0.0023 0.3348 0.258
0.0023 0.2673 0.3232
0.0399 0.2554 0.2554
0.0047 0.511 0.5069
0.0034 0.4803 0.4803
0.0019 1 0.5
0.0019 0.7327 0
0.0023 0.2753 0.3232
0.0023 0.3432 0
0.0023 0.4504 0.4504
0.0023 0.2714 0.4817
0.0023 1 0.5
0.0023 0.2916 0
0.0023 0.3263 0.3263
0.0037 0.3168 0
0.0039 0.3372 0.3117
0.0093 0.2512 0.2512
0.0023 0.5 0.5
0.0023 1 1
0.0023 0.4504 0.4504
0.0019 0.3181 0.3181
0.0023 0.3348 0.258
0.0023 0.5 0.5
0.0023 0.5888 0.1797
0.0019 0.5 0.5
0.0023 0.7511 1
0.0023 1 0.5
0.0064 0.2886 0.2886
0.002 0.2535 0
0.0064 0.2574 0.2752
0.0023 0.5 0.5
0.0019 0.5 0.5
0.0023 0.2766 0.3151
0.0023 1 1
0.0214 0.2516 0.2542
0.0023 1 0.5
0.0023 1 0.5
0.0064 0.4329 0.4329
0.0022 1 1
0.0023 0.5 0.5
0.002 0.2652 0.2652
0.0023 0.5 0.5
0.007 0.4558 0.4802
0.0023 0.3957 0.1341
0.0023 0.2642 0
0.0023 0.5 0.5
0.0023 0.2711 0.367
0.0022 0.3256 0.3256
0.0023 0.3387 0.5
0.0023 0.2798 0.3426
0.0023 1 1
0.0023 0.2987 0.1341
0.0019 0.2519 0
0.0021 1 0.5
0.0041 0.7989 0
0.0023 0.5 0.5
0.002 1 0.5
0.0053 0.4535 0.4535
0.0039 0.2693 0.2693
0.0023 0.2713 0.2713
0.0023 1 0.5
0.007 0.3256 0.4967
0.0023 0.2535 0
0.0019 0.3263 0.3263
0.0023 1 1
0.0023 0.2535 0
0.0019 0.3022 0
0.0019 0.5 0.5
0.0019 1 0.5
0.0023 0.3263 0.3263
0.0019 1 0.5
0.0047 0.511 0.4618
0.0023 1 1
0.0023 0.3685 0
0.0023 1 1
0.0023 1 0.5
0.0023 1 1
0.0047 0.3847 0.3847
0.0054 0.3224 0.3357
0.0023 0.5 0.5
0.0023 1 0.5
0.0055 0.3493 0.3493
0.0019 0.4028 1
0.0023 0.3553 0.3553
0.0023 0.2562 0.1952
0.0023 0.5 0.5
0.0023 0.3387 0.5
0.0019 0.3347 0.3181
0.0128 0.2533 0.2533
0.0045 0.377 0.5069
0.002 0.2721 0.2721
0.0021 0.3387 0.5
0.002 0.3304 0
0.0019 0.3151 0.3151
0.0023 0.2652 0.2652
0.0154 0.4538 0.4535
0.0165 0.3497 0.347
0.0117 0.3647 0.5034
0.0023 0.5 0.5
0.0023 0.5 0.5
0.0022 0.3348 0.274
0.0039 0.2762 0.2762
0.0021 0.3387 0.5
0.0019 0.3853 0
0.0023 0.7367 1
0.0023 0.2753 0.3232
0.002 1 1
0.0339 0.2618 0.2757
0.002 1 0.5
0.0023 0.3449 0
0.0023 0.575 1
0.0023 0.5 0.5
0.0019 0.3348 0.258
0.0023 0.3134 0.3134
0.0058 0.3776 0.324
0.0047 0.5313 0.4244
0.0047 0.3724 0.2391
0.0238 0.2768 0.3057
0.0022 1 1
0.0019 0.2959 0.2843
0.0041 0.3485 0.4949
0.0023 0.2535 0
0.0023 0.7367 1
0.0023 1 1
0.0023 0.3806 0.3806
0.0023 0.3531 0.337
0.0023 0.5 0.5
0.002 0.3387 0.5
0.0047 0.5011 0.5011
0.0023 0.2753 0.5238
0.0023 0.3387 0.5
0.0064 0.3918 0.4111
0.0023 0.3387 0.5
0.0023 0.2946 0.5
0.002 0.3348 0.258
0.0023 1 0.5
0.0093 0.2875 0.4494
0.0064 0.2672 0.5839
0.0023 0.3151 0.3151
0.0023 0.5 0.5
0.0023 0.6637 0
0.0023 1 0.5
0.002 0.5 0.5
0.0019 0.3347 0.3181
0.0019 0.3104 0.2831
0.0047 0.5172 0.4687
0.0023 1 1
0.0023 0.2753 0.3151
0.0039 0.5313 0.4244
0.0054 0.4092 0.3842
0.0023 0.4504 0.4504
0.0241 0.2692 0.2966
0.0023 0.3181 0.3181
0.0023 1 0.5
0.0204 0.2591 0.2591
0.0023 0.575 1
0.0023 0.3181 0.3181
0.0023 0.3348 0
0.0021 0.3151 0.3151
0.0019 0.2535 0
0.0042 0.2846 0
0.012 0.273 0.2729
0.002 0.2673 0.389
0.0023 1 1
0.0023 0.6637 0
0.0023 0.2652 0.2652
0.0023 1 1
0.0264 0.2558 0.2558
0.0019 0.2519 0
0.0023 0.3387 0.5
0.0023 0.2981 0
0.0019 0.3387 0.5
0.0023 0.5 0.5
0.0023 1 1
0.0042 0.3955 0.4784
0.0021 1 0.5
0.0023 0.3387 0.5
0.0023 0.2642 0
0.0023 0.5 0.5
0.0023 1 1
0.0019 1 0.5
0.0019 1 1
0.0023 0.2753 0.5238
0.0023 1 1
0.0021 0.3348 0
0.0023 1 1
0.0073 0.2877 0.3632
0.0082 0.3672 0.3672
0.0019 0.5 0.5
0.0021 0.2652 0.2652
0.0023 0.2642 0
0.0038 0.3192 0
0.0322 0.2904 0.4695
0.0023 0.3348 0.258
0.0022 0.3902 0.1192
0.0019 0.5 0.5
0.0023 1 0.5
0.0023 0.5 0.5
0.0021 0.5052 0.5052
0.0023 0.4504 0.4504
0.0021 0.2754 0.2754
0.0047 0.528 0.528
0.0023 0.2753 0.5238
0.0023 0.317 0.317
0.0023 0.675 0.675
0.0022 1 0.5
0.0023 0.7367 1
0.0023 1 1
0.0023 1 1
0.0019 0.5 0.5
0.0023 1 0.5
0.0023 0.2766 0.3151
0.002 0.3348 0
0.0023 1 0.5
0.0023 0.5 0.5
0.0019 0.5 0.5
0.0228 0.2628 0.5072
0.0055 0.2573 0.611
0.0023 0.2694 0
0.0023 0.3348 0.258
0.0023 1 1
0.0023 0.675 0.675
0.0021 0.3387 0.5
0.0023 0.258 0.258
0.0019 0.2597 0
0.0023 1 0.5
0.0023 1 0.5
0.0019 1 1
0.002 0.5 0.5
0.0023 0.2849 0.2276
0.0019 0.2673 0.3016
0.0038 0.3483 0.4692
0.0021 1 1
0.0227 0.288 0.288
0.002 0.2652 0.2652
0.0022 0.3256 0.3256
0.0023 0.3387 0.5
0.0023 0.7367 1
0.0122 0.2553 0.252
0.0023 1 1
0.0021 0.3348 0.258
0.0023 0.3218 0.3218
0.0022 0.2885 0
0.0071 0.4669 0.3464
0.0021 0.2535 0
0.0064 0.3585 0.3585
0.0019 0.5 0.5
0.0019 1 1
0.0023 0.3348 0.0183
0.0023 0.5 0.5
0.0047 0.3199 0.1694
0.0019 1 1
0.002 1 0.5
0.0023 0.5 0.5
0.007 0.2982 0.3643
0.0023 1 0.5
0.0021 0.2673 0.3151
0.0023 0.5 0.5
0.0023 0.253 0
0.0152 0.4538 0.4526
0.0023 1 1
0.0023 0.4661 0.5
0.0052 0.3606 0.3606
0.0023 0.7511 1
0.0019 0.3348 0.0183
0.0217 0.3352 0.6056
0.0023 1 0.5
0.0023 1 1
0.0023 0.7367 1
0.0021 0.4755 0.4755
0.0023 0.5 0.5
0.0019 0.2853 0
0.0076 0.6516 0.6516
0.0023 0.5 0.5
0.0021 0.3055 0.349
0.0023 0.7511 1
0.0023 0.3363 0
0.0023 0.7367 1
0.0023 0.4504 0.4504
0.0023 0.2714 0.5837
0.0023 0.2535 0
0.0023 0.3387 0.5
0.0041 0.2683 0.2683
0.0279 0.2782 0.2758
0.0019 0.7367 1
0.0023 1 0.5
0.002 0.3366 0.258
0.0023 0.2652 0.2652
0.0023 0.5 0.5
0.0274 0.3362 0.3729
0.0037 0.4854 0.4723
0.0224 0.2581 0.5275
0.0023 0.2753 0.5238
0.0252 0.2826 0.3039
0.0023 0.4504 0.4504
0.0023 0.5 0.5
0.0062 0.2833 0.2833
0.0023 0.5 0.5
0.0023 0.3387 0.5
0.0023 0.6637 0
0.0019 1 1
0.0047 0.3732 0.5069
0.0022 0.2569 0
0.0041 0.3857 0.2252
0.002 0.2983 0
0.0093 0.4436 0.3528
0.0023 0.3348 0.0183
0.0023 1 1
0.0023 0.4504 0.4504
0.0247 0.2827 0.279
0.0023 0.3292 0
0.0023 0.2731 0
0.0023 0.435 0.435
0.0021 0.4091 0
0.0023 0.3263 0.3263
0.0023 0.5 0.5
0.0078 0.2991 0.4229
0.0214 0.2976 0.2976
0.0023 0.6637 0.6577
0.0051 0.2537 0.2537
0.0019 0.7511 1
0.0019 0.3348 0.0183
0.0023 1 1
0.0023 0.5 0.5
0.0023 1 0.5
0.0021 0.3553 0.3553
0.0047 0.511 0
0.0023 0.5 0.5
0.002 0.2914 0
0.0041 0.4387 0.4387
0.0023 1 0.5
0.0047 0.5167 0.4574
0.0023 0.3387 0.5
0.0021 1 1
0.0023 1 1
0.0023 1 1
0.0021 0.2642 0
0.0023 1 1
0.0047 0.5069 0.5069
0.0023 0.3387 0.5
0.0045 0.4388 0.4277
0.0023 0.2877 1
0.0021 0.3348 0
0.0023 1 0.5
0.0023 0.2642 0
0.0023 0.5 0.5
0.0023 1 1
0.0023 0.3348 0.258
0.0019 0.4504 0.4504
0.0021 0.3151 0.3151
0.0052 0.3606 0.3606
0.0107 0.5152 0.3842
0.0023 0.5 0.5
0.0019 0.3181 0.3181
0.0064 0.295 0
0.0023 0.7511 1
0.0023 0.3387 0.5
0.0023 1 1
0.0023 0.2558 0.5454
0.0023 0.5 0.5
0.0023 1 1
0.0021 0.2673 0.3151
0.0019 0.5034 1
0.0034 0.3986 0.3986
0.0023 0.3387 0.5
0.0021 0.3387 0.5
0.0019 0.2673 0.3016
0.0057 0.3579 0.3533
0.0021 1 1
0.0023 1 1
0.002 0.3348 0
0.0023 1 0.5
0.0102 0.2827 0.2813
0.0019 1 1
0.0023 0.3387 0.5
0.0023 0.2642 0
0.0023 0.3387 1
0.0041 0.3 0.1934

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier EgrG_000434800 (Echinococcus granulosus), terminal deoxycytidyl transferase rev1
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