Detailed view for EgrG_000814350

Basic information

TDR Targets ID: 590845
Echinococcus granulosus, cytochrome P450 2K1
Source Database / ID:  GeneDB

pI: 7.5513 | Length (AA): 509 | MW (Da): 57602 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00067   Cytochrome P450

Gene Ontology

Mouse over links to read term descriptions.
GO:0016705   oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  
GO:0020037   heme binding  
GO:0005506   iron ion binding  
GO:0055114   oxidation reduction  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
42 508 2fdv (A) 30 494 17.00 0 1 1.05259 -0.02
44 506 5ufg (A) 29 489 23.00 0 1 1.07883 -0.07
44 509 1nr6 (A) 28 488 17.00 0 0.99 1.12832 0.12
45 93 2ve3 (A) 13 60 40.00 0.12 0.99 0.473467 0.54
47 93 5jkv (A) 48 98 23.00 0 0.33 0.223138 0.31

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_186258)

Species Accession Gene Product
Echinococcus granulosus EgrG_000814350   cytochrome P450 2K1
Echinococcus multilocularis EmuJ_000814350  
Schistosoma japonicum Sjp_0213500   IPR001128,Cytochrome P450,domain-containing
Schistosoma japonicum Sjp_0213510   ko:K00517 CYP81D8 (cytochrome P450, family 81, subfamily D, polypeptide 8); oxygen binding [EC:1.14.-.-], putative
Schistosoma mansoni Smp_156400   cytochrome P450

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cytochrome P450 2D3 500 aa 22.9% 493 aa Compounds References
Rattus norvegicus Cytochrome P450 2A2 492 aa 22.2% 499 aa Compounds References
Canis familiaris Cytochrome P450 2B11 494 aa 20.4% 494 aa Compounds References
Rattus norvegicus Cytochrome P450 2E1 493 aa 21.6% 501 aa Compounds References
Helianthus tuberosus Trans-cinnamate 4-monooxygenase 505 aa 18.4% 488 aa Compounds References
Rattus norvegicus Cytochrome P450 2D2 500 aa 23.5% 468 aa Compounds References
Oryctolagus cuniculus Cytochrome P450 2B4 491 aa 22.0% 501 aa Compounds References
Rattus norvegicus Cytochrome P450 2D1 504 aa 20.5% 503 aa Compounds References
Thlaspi arvense Cytochrome P450 71B1 496 aa 20.5% 464 aa Compounds References
Rattus norvegicus Cytochrome P450 2C23 494 aa 20.3% 487 aa Compounds References
Rattus norvegicus Cytochrome P450 2D18 500 aa 22.0% 496 aa Compounds References
Rattus norvegicus Cytochrome P450 2B1 491 aa 21.8% 435 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0038 0.525 0.525
0.0059 0.5 0.5
0.0004 0.5 0.5
0.015 0.2827 0.5883
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0104 0.5 0.5
0.0122 0.4249 0.5607
0.0004 0.5 0.5
0.0047 0.6689 1
0.015 0.2827 0.5883
0.0058 0.5 0.5
0.0056 0.6399 0.8849
0.0011 0.5 0.5
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0217 0.8044 1
0.0018 0.5 0.5
0.0075 0.2816 0.7261
0.0004 0.5 0.5
0.0032 1 1
0.0065 1 1
0.008 0.2556 0
0.0046 0.6591 0.6342
0.0007 1 1
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0054 1 1
0.0008 0.3317 0.3317
0.0007 1 1
0.0071 0.3514 0.3514
0.0203 0.2689 1
0.004 1 1
0.0022 0.5 0.5
0.0067 0.5 0.5
0.0331 0.3985 0.3984
0.0569 0.2624 0.3244
0.0069 1 1
0.008 0.5 0.5
0.005 0.3622 0.3703
0.0004 0.5 0.5
0.0326 0.2819 1
0.0021 0.4036 0.4186
0.0011 0.5 0.5
0.0124 0.2696 0.2696
0.000376403 0.5 0.5
0.0055 0.5 0.5
0.0443 0.3118 0.5879
0.0267 0.27 0.3733
0.0569 0.2624 0.3244
0.0036 0.5 0.5
0.0078 0.3003 0.398
0.0076 1 1
0.0065 0.5 0.5
0.0166 0.5366 1
0.0065 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.003 0.3514 1
0.0004 0.5 0.5
0.0011 1 1
0.0004 0.5 0.5
0.0063 0.5 0.5
0.0012 0.5 0.5
0.0004 0.5 0.5
0.0028 0.5 0.5
0.0027 1 1
0.0011 1 1
0.0019 0.5 0.5
0.0007 0.5 0.5
0.0032 0.5 0.5
0.033 0.3723 0.385
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0184 0.3352 0.3352
0.0019 0.271 0.3231
0.0291 0.2657 1
0.0004 0.5 0.5
0.0166 0.2888 0.3628
0.006 0.2795 1
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0019 0.2756 0.3071
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0056 0.3577 1
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0059 0.6064 0.6758
0.0111 0.3549 1
0.0018 0.2637 0.257
0.0004 0.5 0.5
0.0029 0.36 0.7305
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0193 0.311 0.4319
0.0034 0.337 0.337
0.0092 0.467 1
0.0042 0.3378 1
0.0004 0.5 0.5
0.0121 1 1
0.0228 0.2829 0.5891
0.0008 0.5 0.5
0.0133 0.256 0.256
0.0004 0.5 0.5
0.0353 0.4928 0.4903
0.0012 1 1
0.0015 0.5 0.5
0.00451124 0.405669 1
0.0057 0.2766 0.2752
0.0016 1 1
0.0047 0.6638 1
0.0004 0.5 0.5
0.0018 0.5 0.5
0.0023 0.5 0.5
0.0033 0.5 0.5
0.0004 0.5 0.5
0.0033 0.5 0.5
0.0004 0.5 0.5
0.0102 0.3061 0.3475
0.0167 0.2978 0.4099
0.0078 1 1
0.0246 0.2667 0.5
0.0014 0.5 0.5
0.0004 0.5 0.5
0.0235 0.3192 0.4038
0.0044 0.6112 1
0.0018 0.5004 0.4883
0.0268 0.2982 0.2981
0.0068 0.5 0.5
0.0022 0.3789 0.3789
0.0004 0.5 0.5
0.0094 0.2887 0.7231
0.0099 0.7122 1
0.0157 0.3541 0.4816
0.0081 0.5 0.5
0.026 0.251 0.4445
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 1 1
0.0051 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0051 0.5 0.5
0.0073 1 1
0.0004 0.5 0.5
0.0289 0.2916 0.3885
0.0003 0.5 0.5
0.0069 0.2847 0.4473
0.0018 0.5 0.5
0.0331 0.3985 0.3984
0.0068 0.4312 1
0.0173 0.3858 0.4862
0.0137 0.271 0.2968
0.0027 0.5 0.5
0.0004 0.5 0.5
0.0011 1 1
0.0051 0.4977 1
0.0008 0.5 0.5
0.000376403 0.5 0.5
0.0004 0.5 0.5
0.0046 0.6591 0.6342
0.0004 0.5 0.5
0.0103 0.6953 1
0.0368 0.2796 1
0.0073 1 1
0.0068 1 1
0.0018 0.5 0.5
0.0004 0.5 0.5
0.0202 0.2702 0.3684
0.0184 0.3508 0.4649
0.0004 0.5 0.5
0.00184047 0.269186 0.409587
0.0052 0.3769 0.3864
0.0286 1 1
0.0019 0.5 0.5
0.00109509 1 1
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0146 0.6069 0.6069
0.0012 0.5 0.5
0.0042 1 1
0.0028 0.5 0.5
0.0051 0.3758 0.4008
0.0118 0.3485 0.7336
0.0004 0.5 0.5
0.0048 1 1
0.0044 0.4237 1
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.000396385 0.5 0.5
0.0026 0.5 0.5
0.0003 0.5 0.5
0.005 0.2698 0.3408
0.0048 0.6597 1
0.007 1 1
0.0004 0.5 0.5
0.0007 0.5 0.5
0.033 0.3723 0.385
0.0103 0.4147 0.4168
0.0026 0.5 0.5
0.0003 0.5 0.5
0.0284 0.2924 0.3384
0.0048 0.6634 1
0.0054 0.5 0.5
0.0071 0.9628 1
0.0189 0.5524 1
0.0004 0.5 0.5
0.0185 0.2528 1
0.0093 0.3481 0.4224
0.0083 0.6735 1
0.01 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0084 1 1
0.0022 0.3489 0.3489
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0156 0.4244 0.7927
0.0197 0.6846 0.9033
0.0032 0.5 0.5
0.0119 0.4458 1
0.0082 0.5 0.5
0.0042 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.00213675 0.269186 0.409587
0.0004 0.5 0.5
0.0066 1 1
0.0004 0.5 0.5
0.036 0.2841 0.4174
0.0004 0.5 0.5
0.0038 1 1
0.0361 0.2704 1
0.0032 0.5 0.5
0.0036 0.4353 1
0.0046 0.5 0.5
0.0004 0.5 0.5
0.0027 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0045 0.5 0.5
0.0012 0.5 0.5
0.0336 0.2847 1
0.0018 0.5004 0.4883
0.0106 0.2751 1
0.033 0.3723 0.385
0.0323 0.2823 0.2823
0.0119 0.4458 1
0.0004 0.5 0.5
0.0008 1 1
0.0093 0.5 0.5
0.0028 0.2972 1
0.0323 0.3673 0.3672
0.0063 0.3886 1
0.0016 0.5 0.5
0.0146 0.6654 0.6654
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0008 0.5 0.5
0.0082 0.5 0.5
0.0284 0.2924 0.3384
0.003 0.3271 0.3271
0.0045 0.5 0.5
0.0324 0.2701 0.815
0.0011 0.5 0.5
0.0083 0.5 0.5
0.0018 1 1
0.0249 0.3082 1
0.0044 0.2627 0.2239
0.0016 1 1
0.007 0.5713 0.5
0.0073 0.5 0.5
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0011 0.5 0.5
0.0033 0.3348 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0002 0.5 0.5
0.0004 0.5 0.5
0.0346 0.2559 0.4088
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0075 1 1
0.0004 0.5 0.5
0.0023 0.5 0.5
0.0015 0.5 0.5
0.0059 0.6064 0.6758
0.0004 0.5 0.5
0.0316 0.2652 0.2784
0.0084 0.5 0.5
0.0047 0.5 0.5
0.0108 0.2733 1
0.0099 0.7062 1
0.0067 0.5 0.5
0.0004 0.5 0.5
0.0072 1 1
0.0029 0.5 0.5
0.025 0.2789 1
0.0004 0.5 0.5
0.0029 1 1
0.0012 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0062 0.5 0.5
0.0004 0.5 0.5
0.0004 1 1
0.0087 1 1
0.0071 0.5 0.5
0.0012 0.5 0.5
0.00213675 0.269186 0.409587
0.0067 0.5 0.5
0.0069 0.5 0.5
0.0087 1 1
0.0012 0.5 0.5
0.0008 0.5 0.5
0.0032 1 1
0.0004 0.5 0.5
0.0066 0.5 0.5
0.0388 0.2772 1
0.0011 0.5 0.5
0.0145 0.7126 0.7126
0.0004 0.5 0.5
0.0083 1 1
0.0049 0.293 0.9307
0.0004 0.5 0.5
0.004 1 1
0.007 0.5 0.5
0.0084 0.3462 0.4489
0.004 0.5565 1
0.0004 0.5 0.5
0.0127 0.5337 0.5337
0.0004 0.5 0.5
0.0065 0.3393 0
0.0004 0.5 0.5
0.00213675 0.269186 0.409587
0.0045 0.5 0.5
0.0057 0.2766 0.2752
0.026 0.251 0.4445
0.00505219 0.5 0.5
0.005 1 1
0.0008 0.5 0.5
0.008 0.2582 1
0.0008 0.5 0.5
0.0025 0.5 0.5
0.0004 1 1
0.0094 0.5 0.5
0.0023 1 1
0.0164 0.3784 1
0.0004 0.5 0.5
0.0053 1 1
0.0059 0.6064 0.6758
0.0353 0.4928 0.4903
0.0059 0.6064 0.6758
0.0004 0.5 0.5
0.0075 0.3265 0.4928
0.0368 0.2796 1
0.0004 0.5 0.5
0.0046 0.5 0.5
0.0119 0.5 0.5
0.0004 0.5 0.5
0.0026 0.5 0.5
0.0004 0.5 0.5
0.0091 0.2951 1
0.004 1 1
0.0074 1 1
0.0011 0.5 0.5
0.0262 0.3083 0.3083
0.0004 0.5 0.5
0.0004 0.5 0.5
0.002 1 1
0.0037 0.2694 0.2389
0.0007 0.5 0.5
0.004 1 1
0.0388 0.2772 1
0.0004 0.5 0.5
0.0341 0.2689 1
0.0079 0.2909 0.3548
0.0176 0.3425 0.3423
0.0008 0.3317 0.3317
0.0052 0.3825 0.408
0.0004 0.5 0.5
0.007 1 1
0.0052 0.2829 0.5822
0.0015 0.5 0.5
0.0023 1 1
0.015 0.3435 0.4459
0.0015 0.5 0.5
0.0004 0.5 0.5
0.000218985 0.5 0.5
0.004 1 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0063 0.2543 0.2543
0.007 0.3303 0.4926
0.0021 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0049 0.6682 1
0.0022 0.5 0.5
0.0004 0.5 0.5
0.0072 1 1
0.0019 0.5 0.5
0.0284 0.2726 1
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0033 0.5 0.5
0.0081 0.5 0.5
0.0004 0.5 0.5
0.034 0.2765 1
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0316 0.2652 0.2784
0.0047 0.6638 1
0.0036 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0162 0.2769 0.2769
0.0114 1 1
0.000218985 0.5 0.5
0.0015 0.5 0.5
0.0004 0.5 0.5
0.002 0.5 0.5
0.0216 0.2583 1
0.0103 1 1
0.0004 0.5 0.5
0.0174 0.2937 0.4345
0.0133 0.2787 0.2785
0.0033 0.2605 0.4761
0.0019 0.5 0.5
0.0038 0.5 0.5
0.0235 0.2812 0.2815
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0018 0.3602 0.3602
0.0082 0.5 0.5
0.0092 1 1
0.0004 0.5 0.5
0.0015 0.5 0.5
0.0008 0.5 0.5
0.0037 0.4283 0.6306
0.0023 0.9674 0.9674
0.0004 0.5 0.5
0.0008 0.5 0.5
0.0004 0.5 0.5
0.0077 0.5 0.5
0.0012 0.5 0.5
0.0038 0.5102 0
0.0173 0.3457 0.435
0.0004 0.5 0.5
0.0011 0.5 0.5
0.0004 0.5 0.5
0.0114 1 1
0.0063 0.5 0.5
0.0062 0.2905 0.8174
0.0004 0.5 0.5
0.005 0.5 0.5
0.0036 1 1
0.0004 0.5 0.5
0.0007 0.5 0.5
0.0018 0.2876 0.7901
0.0063 0.4653 0.496
0.0046 0.2608 0.2211
0.008 1 1
0.0004 0.5 0.5
0.0025 0.5 0.5
0.0217 0.2742 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0004 0.5 0.5
0.0059 0.5 0.5
0.0086 0.5 0.5
0.0055 0.2887 0.2887
0.0071 0.2928 1
0.0071 0.5 0.5
0.0004 0.5 0.5
0.00777519 0.280873 1
0.00139338 1 1
0.00213675 0.269186 0.409587
0.0035 0.4422 0.7542
0.0019 0.271 0.3231

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000814350 (Echinococcus granulosus), cytochrome P450 2K1
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