pI: 7.988 |
Length (AA): 343 |
MW (Da): 36889 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
26 | 305 | 4egf (A) | 12 | 260 | 27.00 | 0 | 1 | 1.01763 | -0.05 |
27 | 242 | 3edm (C) | 3 | 233 | 23.00 | 0 | 1 | 0.866038 | -0.4 |
28 | 246 | 4y9d (A) | 4 | 246 | 27.00 | 0 | 1 | 0.916684 | -0.63 |
28 | 295 | 5b4t (A) | 2 | 244 | 29.00 | 0.0000000032 | 1 | 1.04744 | 0 |
33 | 224 | 3u9l (A) | 6 | 190 | 37.00 | 0.00000000002 | 1 | 0.866867 | 0.39 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128149)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G19200 | 3-ketodihydrosphinganine reductase-like protein |
Arabidopsis thaliana | AT3G06060 | 3-ketodihydrosphinganine reductase-like protein |
Brugia malayi | Bm1_37690 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Brugia malayi | Bm1_37695 | hypothetical protein |
Candida albicans | CaO19.6131 | 3-ketosphinganine reductase |
Candida albicans | CaO19.13550 | 3-ketosphinganine reductase |
Caenorhabditis elegans | CELE_Y37E11AM.3 | Protein Y37E11AM.3 |
Dictyostelium discoideum | DDB_G0272883 | 3-dehydrosphinganine reductase |
Dictyostelium discoideum | DDB_G0274015 | 3-dehydrosphinganine reductase |
Drosophila melanogaster | Dmel_CG10425 | CG10425 gene product from transcript CG10425-RA |
Echinococcus granulosus | EgrG_000109500 | 3 ketodihydrosphingosine reductase |
Entamoeba histolytica | EHI_200770 | 3-ketodihydrosphingosine reductase protein, putative |
Echinococcus multilocularis | EmuJ_000109500 | 3 ketodihydrosphingosine reductase |
Homo sapiens | ENSG00000119537 | 3-ketodihydrosphingosine reductase |
Leishmania braziliensis | LbrM.34.0370 | short chain dehydrogenase, putative |
Leishmania donovani | LdBPK_350330.1 | short chain dehydrogenase, putative |
Leishmania infantum | LinJ.35.0330 | short chain dehydrogenase, putative |
Leishmania major | LmjF.35.0330 | 3-keto-dihydrosphingosine reductase |
Leishmania mexicana | LmxM.34.0330 | short chain dehydrogenase, putative |
Loa Loa (eye worm) | LOAG_06611 | hypothetical protein |
Loa Loa (eye worm) | LOAG_06610 | hypothetical protein |
Mus musculus | ENSMUSG00000009905 | 3-ketodihydrosphingosine reductase |
Neospora caninum | NCLIV_019810 | 3-ketodihydrosphingosine reductase TSC10 (EC 1.1.1.102), related |
Oryza sativa | 4330439 | Os02g0701900 |
Plasmodium berghei | PBANKA_1007100 | conserved Plasmodium protein, unknown function |
Plasmodium falciparum | PF3D7_0409500 | conserved Plasmodium protein, unknown function |
Plasmodium knowlesi | PKNH_0307600 | NAD(P)-binding protein/reductase, putative |
Plasmodium vivax | PVX_000770 | hypothetical protein, conserved |
Plasmodium yoelii | PY04092 | hypothetical protein |
Saccharomyces cerevisiae | YBR265W | 3-dehydrosphinganine reductase |
Schistosoma japonicum | Sjp_0074380 | ko:K04708 3-dehydrosphinganine reductase [EC1.1.1.102], putative |
Schistosoma mansoni | Smp_141720 | 3-keto-dihydrosphingosine reductase |
Schmidtea mediterranea | mk4.000801.06 | 3-keto-dihydrosphingosine reductase |
Schmidtea mediterranea | mk4.005011.00 | 3-keto-dihydrosphingosine reductase |
Trypanosoma brucei gambiense | Tbg972.10.5030 | short-chain dehydrogenase, putative |
Trypanosoma brucei | Tb927.10.4040 | 3-keto-dihydrosphingosine reductase |
Trypanosoma congolense | TcIL3000_10_3370 | short-chain dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.506959.64 | 3-keto-dihydrosphingosine reductase |
Trypanosoma cruzi | TcCLB.510997.10 | 3-keto-dihydrosphingosine reductase |
Trichomonas vaginalis | TVAG_468060 | short-chain dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.4040 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.4040 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.4040 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.4040 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
YBR265W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_1007100 | Plasmodium berghei | Dispensable | plasmo |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | 11-beta-hydroxysteroid dehydrogenase 1 | 288 aa | 25.0% | 248 aa | Compounds | References |
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 27.5% | 160 aa | Compounds | References |