Detailed view for EgrG_000427200

Basic information

TDR Targets ID: 591664
Echinococcus granulosus, protein arginine N methyltransferase 7
Source Database / ID:  GeneDB

pI: 6.275 | Length (AA): 764 | MW (Da): 85233 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06325   Ribosomal protein L11 methyltransferase (PrmA)

Gene Ontology

Mouse over links to read term descriptions.
GO:0008168   methyltransferase activity  
GO:0006479   protein amino acid methylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
28 762 3wst (A) 2 642 28.00 0 1 1.08064 0.6
46 196 3tfw (A) 23 165 18.00 0 1 0.419244 -0.58
51 763 4c4a (A) 27 687 34.00 0 1 1.20915 -0.07
52 695 4c4a (A) 28 622 37.00 0 1 1.12733 0.38
91 144 2ozv (A) 47 104 28.00 0 0.12 0.233281 0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130603)

Species Accession Gene Product
Arabidopsis thaliana AT4G16570   protein arginine N-methyltransferase 7
Brugia malayi Bm1_54220   Protein arginine N-methyltransferase
Caenorhabditis elegans CELE_W06D4.4   Protein PRMT-7
Drosophila melanogaster Dmel_CG9882   Arginine methyltransferase 7
Echinococcus granulosus EgrG_000427200   protein arginine N methyltransferase 7
Echinococcus multilocularis EmuJ_000427200   protein arginine N methyltransferase 7
Homo sapiens ENSG00000132600   protein arginine methyltransferase 7
Leishmania braziliensis LbrM.06.0840   arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490
Leishmania donovani LdBPK_060900.1   protein arginine n-methyltransferase 7
Leishmania infantum LinJ.06.0900   arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490
Leishmania major LmjF.06.0870   arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490
Leishmania mexicana LmxM.06.0870   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05876   protein arginine N-methyltransferase
Mus musculus 214572   protein arginine N-methyltransferase 7
Oryza sativa 4339860   Os06g0105500
Schistosoma japonicum Sjp_0112410   ko:K00599 PRMT7, LOC479677; protein arginine methyltransferase 7 [EC:2.1.1.-], putative
Schistosoma japonicum Sjp_0095560   Protein arginine N-methyltransferase 7, putative
Schistosoma mansoni Smp_025550   protein arginine n-methyltransferase
Schmidtea mediterranea mk4.002889.01   Protein arginine N-methyltransferase 7
Trypanosoma brucei gambiense Tbg972.7.6370   arginine N-methyltransferase, putative
Trypanosoma brucei Tb927.7.5490   protein arginine n-methyltransferase 7
Trypanosoma cruzi TcCLB.510303.310   protein arginine n-methyltransferase 7
Trypanosoma cruzi TcCLB.509153.100   arginine N-methyltransferase, type III

Essentiality

EgrG_000427200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.5490 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.5490 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.5490 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.5490 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens protein arginine methyltransferase 7 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.00730405 0.497396 1
0.0146 0.2809 0.4021
0.0153 1 1
0.0081 0.2689 0.4225
0.0145 0.3281 0.3281
0.0068 0.2886 0.2886
0.0047 0.255 0.2521
0.0115 0.3391 0.5198
0.0163 0.2892 0.5431
0.0081 0.2689 0.4225

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000427200 (Echinococcus granulosus), protein arginine N methyltransferase 7
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