Detailed view for EgrG_000597400

Basic information

TDR Targets ID: 592098
Echinococcus granulosus, solute carrier family 13
Source Database / ID:  GeneDB

pI: 7.4517 | Length (AA): 599 | MW (Da): 65644 | Paralog Number: 2

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 8

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00939   Sodium:sulfate symporter transmembrane region

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006814   sodium ion transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 470 4f35 (D) 67 461 21.00 0.0000000084 0.85 0.867671 0.63
54 469 4f35 (D) 123 460 25.00 0 1 0.816485 0.76
73 460 4f35 (D) 142 453 31.00 0 0.96 0.598408 1.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127239)

Species Accession Gene Product
Arabidopsis thaliana AT5G47560   tonoplast dicarboxylate transporter
Brugia malayi Bm1_36950   NaDC-2
Candida albicans CaO19.2454   similar to S. cerevisiae phosphate permease PHO87
Candida albicans CaO19.9990   similar to S. cerevisiae phosphate permease PHO87
Candida albicans CaO19.11147   similar to S. cerevisiae low-affinity phosphate transporter PHO91
Candida albicans CaO19.3663   similar to S. cerevisiae low-affinity phosphate transporter PHO91
Caenorhabditis elegans CELE_F31F6.6   Protein NAC-1
Caenorhabditis elegans CELE_K08E5.2   Protein NAC-3, isoform B
Drosophila melanogaster Dmel_CG33934   CG33934 gene product from transcript CG33934-RE
Drosophila melanogaster Dmel_CG3979   I'm not dead yet
Drosophila melanogaster Dmel_CG33933   I'm not dead yet 2
Echinococcus granulosus EgrG_000009500   solute carrier family 13
Echinococcus granulosus EgrG_000658200   solute carrier family 13
Echinococcus granulosus EgrG_000597400   solute carrier family 13
Echinococcus multilocularis EmuJ_000597400   solute carrier family 13
Echinococcus multilocularis EmuJ_000009500   solute carrier family 13
Echinococcus multilocularis EmuJ_000658200   solute carrier family 13
Homo sapiens ENSG00000141485   solute carrier family 13 (sodium-dependent citrate transporter), member 5
Homo sapiens ENSG00000007216   solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Leishmania braziliensis LbrM.28.3140   sodium/sulphate symporter, putative
Leishmania donovani LdBPK_283160.1   Low-affinity phosphate transporter PHO91
Leishmania infantum LinJ.28.3160   sodium/sulphate symporter, putative
Leishmania major LmjF.28.2930   sodium/sulphate symporter, putative
Leishmania mexicana LmxM.28.2930   sodium/sulphate symporter, putative
Loa Loa (eye worm) LOAG_07442   hypothetical protein
Mus musculus ENSMUSG00000001095   solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
Mus musculus ENSMUSG00000020805   solute carrier family 13 (sodium-dependent citrate transporter), member 5
Neospora caninum NCLIV_029960   solute carrier family 13, putative
Oryza sativa 4347418   Os09g0484900
Oryza sativa 4345968   Os08g0503700
Saccharomyces cerevisiae YNR013C   Pho91p
Saccharomyces cerevisiae YJL198W   Pho90p
Saccharomyces cerevisiae YCR037C   Pho87p
Schistosoma japonicum Sjp_0102290   IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing
Schistosoma japonicum Sjp_0102300   Solute carrier family 13 member 5, putative
Schistosoma japonicum Sjp_0060100   expressed protein
Schistosoma japonicum Sjp_0107740   Solute carrier family 13 member 4, putative
Schistosoma japonicum Sjp_0313150   Solute carrier family 13 member 2, putative
Schistosoma mansoni Smp_170080   sodium/dicarboxylate cotransporter-related
Schistosoma mansoni Smp_185030   hypothetical protein
Schmidtea mediterranea mk4.003673.02  
Schmidtea mediterranea mk4.016547.00  
Schmidtea mediterranea mk4.000332.01   Sodium-dependent high-affinity dicarboxylate transporter 3
Schmidtea mediterranea mk4.003673.00   Sodium-dependent high-affinity dicarboxylate transporter 3
Schmidtea mediterranea mk4.003673.01   Sodium/dicarboxylate cotransporter-related
Schmidtea mediterranea mk4.003444.04   Sodium/dicarboxylate cotransporter-related
Schmidtea mediterranea mk4.001055.05  
Schmidtea mediterranea mk4.003444.03   Sodium-dependent high-affinity dicarboxylate transporter 3
Schmidtea mediterranea mk4.000270.04   Sodium/dicarboxylate cotransporter-related
Trypanosoma brucei gambiense Tbg972.11.12490   sodium/sulphate symporter, putative
Trypanosoma congolense TcIL3000.11.11820   Low-affinity phosphate transporter PHO91
Trypanosoma cruzi TcCLB.508831.60   Low-affinity phosphate transporter PHO91
Trichomonas vaginalis TVAG_327510   sodium-dependent high-affinity dicarboxylate transporter, putative
Trichomonas vaginalis TVAG_245560   Inorganic phosphate transporter, putative
Trichomonas vaginalis TVAG_419700   conserved hypothetical protein
Trichomonas vaginalis TVAG_425460   conserved hypothetical protein
Trichomonas vaginalis TVAG_164170   conserved hypothetical protein
Trichomonas vaginalis TVAG_344810   Inorganic phosphate transporter, putative
Trichomonas vaginalis TVAG_355950   conserved hypothetical protein
Trichomonas vaginalis TVAG_308990   conserved hypothetical protein
Trichomonas vaginalis TVAG_416480   conserved hypothetical protein
Trichomonas vaginalis TVAG_423510   conserved hypothetical protein

Essentiality

EgrG_000597400 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
YJL198W Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus solute carrier family 13 (sodium-dependent citrate transporter), member 5 Compounds References
Homo sapiens solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 Compounds References
Rattus norvegicus Solute carrier family 13 member 5 Compounds References
Homo sapiens solute carrier family 13 (sodium-dependent citrate transporter), member 5 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0107 1 0.5
0.0294 1 1
0.0107 0.2755 0.0468
0.0474 1 0.5
0.0107 1 0.5
0.0087 0.4153 0.4153
0.0087 0.4888 0.4888
0.0107 1 0.5
0.0107 1 0.5
0.0087 0.5015 0.5
0.0643 1 1
0.0474 1 0.5
0.0474 1 0.5
0.0618 1 0.5
0.0643 1 1
0.0107 1 0.5
0.009 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EgrG_000597400 (Echinococcus granulosus), solute carrier family 13
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